T Cell Effector Function Quiz

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18 Questions

What is the main function of CD8+ cytotoxic T lymphocytes (CTLs)?

Kill infected cells

What is the role of IL-2 in the proliferation of T cells?

Initiates proliferation

Which molecule on antigen-presenting cells (APCs) activates MHC class II restricted T cells?

ICAM-1

What is the consequence of T cells recognizing antigens without costimulation?

Immune tolerance

What is the function of B7-1 (CD90) in the interaction between class II MHC APCs and CD4+ T cells?

Activates T cell response

What is the end result of signal transduction in a T lymphocyte?

Synthesis of toxins in CTLs

Which molecule binds to CD28 on T cell surfaces during signal transduction after antigen recognition?

B7 costimulatory proteins

What happens if a naive T cell recognizes an antigen without co-stimulation?

Development of tolerance

What is the main role of Intercellular Adhesion Molecule-1 (ICAM-1) in T-cell mediated host defense?

Facilitate binding to APCs

At which stage do naive T cells require a second costimulatory signal for their proliferation and differentiation?

Interaction with class II MHC APCs

Which type of T cell is responsible for killing infected cells containing microbial proteins in the cytosol?

CD8+ cytotoxic T lymphocyte (CTL)

What is the primary function of CD4+ helper T cells in an immune response?

Recruiting and activating phagocytes to destroy microbes

Which subset of effector T cells is responsible for recruiting eosinophils to destroy helminthic parasites?

Th2

What is the primary role of CD8+ T cells in the immune response?

Killing infected cells with microbial antigens in the cytosol

Which effector T cell subset secretes cytokines that recruit leukocytes and activate phagocytes to kill microbes?

Th1

What is the effector function of Th2 subset effector cells?

Recruiting eosinophils to destroy parasites

In an infection site, which T cell subset is specific to leukocyte recruitment?

Th1

What is the main function of CD4+ cells in an immune response?

"Helping" recruit other leukocytes to infection sites

Test your knowledge on the effector functions of activated CD8+ T cells compared to macrophages and CD4+ T cells. Learn about the roles of different subsets of CD4+ T cells in recognizing microbial antigens, recruiting leukocytes, and activating phagocytes. Understand how Th1, Th2, and Th17 subsets function in immune responses.

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