Cell-Mediated Effector Responses and TH-Cell Differentiation Quiz
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Questions and Answers

Which receptor binds to ICAM?

  • MHC/Ag
  • FcR
  • TCR/CD3 complex
  • LFA-1 integrin (correct)

    • What facilitates the entry of granzymes into the target cell?

  • TCR/CD3 complex interaction
  • FcR recognition
  • Perforin-mediated pore formation (correct)
  • MHC/Ag binding

    • Which cells use similar mechanisms to kill target cells as NK cells?

  • NK cells (correct)
  • Macrophages
  • CD4+ T cells
  • Neutrophils

    • What mechanism is used by NK cells, macrophages, neutrophils, and eosinophils to eliminate pathogens?

    <p>Lytic enzymes</p> Signup and view all the answers

    What contributes to pathogen clearance through direct killing by CTL or NK cells?

    <p>Cellular effector responses</p> Signup and view all the answers

    Which type of cells collaborate as bridges with cellular responses?

    <p>B cells</p> Signup and view all the answers

    What do macrophages eliminate once activated by T cells?

    <p>Intracellular pathogens</p> Signup and view all the answers

    What is the main regulator of NK cell activation?

    <p>IL12 and IL-15 cytokines</p> Signup and view all the answers

    Which molecule acquires high avidity for its ligand after antigen recognition?

    <p>LFA-1 integrin receptor</p> Signup and view all the answers

    Which mechanism leads to DNA fragmentation and does not require mRNA or protein synthesis?

    <p>Proteolytic activity of granzymes</p> Signup and view all the answers

    What is the function of Helper T cells?

    <p>Producing a distinct cytokine profile</p> Signup and view all the answers

    How do CTLs recognize foreign antigens?

    <p>Through TCR recognition of antigens presented on MHC class I molecules</p> Signup and view all the answers

    What is the role of IL-2 in CTL activation?

    <p>Inducing proliferation</p> Signup and view all the answers

    How do NK cells recognize target cells?

    <p>By activating and inhibitory receptors</p> Signup and view all the answers

    What are the pathways involved in the destruction of target cells by CTLs?

    <p>Perforin/granzyme pathways</p> Signup and view all the answers

    What is the function of TH17 subset of Helper T cells?

    <p>Producing a distinct cytokine profile</p> Signup and view all the answers

    What is the primary function of TFH subset of Helper T cells?

    <p>Regulating distinct activities within the body</p> Signup and view all the answers

    What is the main function of TREG subset of Helper T cells?

    <p>Regulating distinct activities within the body</p> Signup and view all the answers

    What is the role of ADCC and IgE-mediated activation of eosinophils in helminthic infections?

    <p>Activating eosinophils to combat helminthic infections</p> Signup and view all the answers

    What are the events in the destruction of target cells by CTLs?

    <p>Conjugate formation</p> Signup and view all the answers

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