Cell-Mediated Effector Responses and TH-Cell Differentiation Quiz

Which receptor binds to ICAM?

LFA-1 integrin

What facilitates the entry of granzymes into the target cell?

Perforin-mediated pore formation

Which cells use similar mechanisms to kill target cells as NK cells?

NK cells

What mechanism is used by NK cells, macrophages, neutrophils, and eosinophils to eliminate pathogens?

Lytic enzymes Signup and view all the answers

What contributes to pathogen clearance through direct killing by CTL or NK cells?

Cellular effector responses Signup and view all the answers

Which type of cells collaborate as bridges with cellular responses?

B cells Signup and view all the answers

What do macrophages eliminate once activated by T cells?

Intracellular pathogens Signup and view all the answers

What is the main regulator of NK cell activation?

IL12 and IL-15 cytokines Signup and view all the answers

Which molecule acquires high avidity for its ligand after antigen recognition?

LFA-1 integrin receptor Signup and view all the answers

Which mechanism leads to DNA fragmentation and does not require mRNA or protein synthesis?

Proteolytic activity of granzymes Signup and view all the answers

What is the function of Helper T cells?

Producing a distinct cytokine profile Signup and view all the answers

How do CTLs recognize foreign antigens?

Through TCR recognition of antigens presented on MHC class I molecules Signup and view all the answers

What is the role of IL-2 in CTL activation?

Inducing proliferation Signup and view all the answers

How do NK cells recognize target cells?

By activating and inhibitory receptors Signup and view all the answers

What are the pathways involved in the destruction of target cells by CTLs?

Perforin/granzyme pathways Signup and view all the answers

What is the function of TH17 subset of Helper T cells?

Producing a distinct cytokine profile Signup and view all the answers

What is the primary function of TFH subset of Helper T cells?

Regulating distinct activities within the body Signup and view all the answers

What is the main function of TREG subset of Helper T cells?

Regulating distinct activities within the body Signup and view all the answers

What is the role of ADCC and IgE-mediated activation of eosinophils in helminthic infections?

Activating eosinophils to combat helminthic infections Signup and view all the answers

What are the events in the destruction of target cells by CTLs?

Conjugate formation Signup and view all the answers