Cell-Mediated Effector Responses and TH-Cell Differentiation Quiz

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20 Questions

Which receptor binds to ICAM?

LFA-1 integrin

What facilitates the entry of granzymes into the target cell?

Perforin-mediated pore formation

Which cells use similar mechanisms to kill target cells as NK cells?

NK cells

What mechanism is used by NK cells, macrophages, neutrophils, and eosinophils to eliminate pathogens?

Lytic enzymes

What contributes to pathogen clearance through direct killing by CTL or NK cells?

Cellular effector responses

Which type of cells collaborate as bridges with cellular responses?

B cells

What do macrophages eliminate once activated by T cells?

Intracellular pathogens

What is the main regulator of NK cell activation?

IL12 and IL-15 cytokines

Which molecule acquires high avidity for its ligand after antigen recognition?

LFA-1 integrin receptor

Which mechanism leads to DNA fragmentation and does not require mRNA or protein synthesis?

Proteolytic activity of granzymes

What is the function of Helper T cells?

Producing a distinct cytokine profile

How do CTLs recognize foreign antigens?

Through TCR recognition of antigens presented on MHC class I molecules

What is the role of IL-2 in CTL activation?

Inducing proliferation

How do NK cells recognize target cells?

By activating and inhibitory receptors

What are the pathways involved in the destruction of target cells by CTLs?

Perforin/granzyme pathways

What is the function of TH17 subset of Helper T cells?

Producing a distinct cytokine profile

What is the primary function of TFH subset of Helper T cells?

Regulating distinct activities within the body

What is the main function of TREG subset of Helper T cells?

Regulating distinct activities within the body

What is the role of ADCC and IgE-mediated activation of eosinophils in helminthic infections?

Activating eosinophils to combat helminthic infections

What are the events in the destruction of target cells by CTLs?

Conjugate formation

Test your knowledge on cellular effector responses, including cytolytic responses to microorganisms replicating in the cytoplasm and T-cell-mediated activation of phagocytes. Learn about TH-cell differentiation, including the distinct subsets and their cytokine profiles.

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