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T-Cell Mediated Immunity: Activation and Effector Mechanisms

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T-Cell Mediated Immunity: Activation and Effector Mechanisms

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Questions and Answers

What is the primary purpose of the costimulatory signals provided by APCs to T cells?

To provide the initial signal for T cell activation

To ensure that T cells are maximally activated by microbial antigens and not by harmless foreign substances (correct)

To trigger the release of cytokines like IL-2 that stimulate T cell proliferation

To increase the affinity of the LFA-1 integrin on naive T cells

What is the role of adhesion molecules like LFA-1 on T cells during the T cell response?

They trigger the release of cytokines like IL-2 that stimulate T cell proliferation

They provide the initial signal for T cell activation

They increase the strength of binding between T cells and APCs when the T cell sees an antigen (correct)

They are responsible for the migration of effector T cells

What is the primary function of the biochemical signals triggered by the TCR complex and the CD4/CD8 coreceptor?

To trigger the release of cytokines like IL-2 that stimulate T cell proliferation

To increase the affinity of the LFA-1 integrin on naive T cells

To provide the initiating signal for T cell activation (correct)

To ensure that naive T lymphocytes are activated maximally by microbial antigens and not by harmless foreign substances

What is the primary function of the memory T cells that remain in the system after an immune response?

To facilitate a more rapid and robust response upon re-exposure to the same antigen Signup and view all the answers

What is the primary difference in the circulation and migration patterns between naive and effector T cells?

Naive T cells and effector T cells have different patterns of circulation and migration through tissues, which are critical for their different roles in immune responses Signup and view all the answers

What is the primary function of the CD4 and CD8 coreceptors on T cells during antigen recognition?

To recognize the peptide-MHC complexes on APCs, together with the TCR, and provide part of the initiating signal for T cell activation Signup and view all the answers

What is the major role of T-cells in cell-mediated immunity?

Killing infected cells Signup and view all the answers

Which of the following is NOT a phase of T cell response?

Antibody Production Signup and view all the answers

What initiates the proliferation and differentiation of Naive T lymphocytes?

Antigens in peripheral lymphoid organs Signup and view all the answers

What is the interaction required for destroying cancer cells in cell-mediated immunity?

T lymphocytes with cancer cells Signup and view all the answers

When do effector T cells perform their functions in cell-mediated immunity?

After migrating to the antigen site Signup and view all the answers

What do T lymphocytes assist B cells in producing as part of humoral immune responses?

Antibodies Signup and view all the answers