T-Cell Mediated Immunity: Activation and Effector Mechanisms
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T-Cell Mediated Immunity: Activation and Effector Mechanisms

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Questions and Answers

What is the primary purpose of the costimulatory signals provided by APCs to T cells?

  • To provide the initial signal for T cell activation
  • To ensure that T cells are maximally activated by microbial antigens and not by harmless foreign substances (correct)
  • To trigger the release of cytokines like IL-2 that stimulate T cell proliferation
  • To increase the affinity of the LFA-1 integrin on naive T cells
  • What is the role of adhesion molecules like LFA-1 on T cells during the T cell response?

  • They trigger the release of cytokines like IL-2 that stimulate T cell proliferation
  • They provide the initial signal for T cell activation
  • They increase the strength of binding between T cells and APCs when the T cell sees an antigen (correct)
  • They are responsible for the migration of effector T cells
  • What is the primary function of the biochemical signals triggered by the TCR complex and the CD4/CD8 coreceptor?

  • To trigger the release of cytokines like IL-2 that stimulate T cell proliferation
  • To increase the affinity of the LFA-1 integrin on naive T cells
  • To provide the initiating signal for T cell activation (correct)
  • To ensure that naive T lymphocytes are activated maximally by microbial antigens and not by harmless foreign substances
  • What is the primary function of the memory T cells that remain in the system after an immune response?

    <p>To facilitate a more rapid and robust response upon re-exposure to the same antigen</p> Signup and view all the answers

    What is the primary difference in the circulation and migration patterns between naive and effector T cells?

    <p>Naive T cells and effector T cells have different patterns of circulation and migration through tissues, which are critical for their different roles in immune responses</p> Signup and view all the answers

    What is the primary function of the CD4 and CD8 coreceptors on T cells during antigen recognition?

    <p>To recognize the peptide-MHC complexes on APCs, together with the TCR, and provide part of the initiating signal for T cell activation</p> Signup and view all the answers

    What is the major role of T-cells in cell-mediated immunity?

    <p>Killing infected cells</p> Signup and view all the answers

    Which of the following is NOT a phase of T cell response?

    <p>Antibody Production</p> Signup and view all the answers

    What initiates the proliferation and differentiation of Naive T lymphocytes?

    <p>Antigens in peripheral lymphoid organs</p> Signup and view all the answers

    What is the interaction required for destroying cancer cells in cell-mediated immunity?

    <p>T lymphocytes with cancer cells</p> Signup and view all the answers

    When do effector T cells perform their functions in cell-mediated immunity?

    <p>After migrating to the antigen site</p> Signup and view all the answers

    What do T lymphocytes assist B cells in producing as part of humoral immune responses?

    <p>Antibodies</p> Signup and view all the answers

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