Fungal Infections of the Skin PDF

SUPERFICIAL FUNGAL INFECTIONS OF THE SKIN DERMATOPHYTE INFECTIONS The dermatophytes include a group of fungi (ringworm) that have the ability to infect and survive only on dead keratin (stratum corneum of the skin, the hair, and the nails). Dermatophytes are classified...

SUPERFICIAL FUNGAL INFECTIONS OF THE SKIN DERMATOPHYTE INFECTIONS The dermatophytes include a group of fungi (ringworm) that have the ability to infect and survive only on dead keratin (stratum corneum of the skin, the hair, and the nails). Dermatophytes are classified into 3 genera: Microsporum, Trichophyton, and Epidermophyton.  Clinically skin infections characterized by active border which is scaly, red and slightly elevated. Vesicles occur in intense inflammation. As the lesion expands the center become relatively clear.  This classical pattern of presentation present in all locations except the palms and soles. Investigations  KOH wet mount preparation: dermatophytes appear as translucent branching, rod-shaped filaments (hyphae) of uniform width with lines of separation (septa).  Culture: is used to identify the species of dermatophytes. There are Mycosel agar and Sabouraud agar.  Wood’s light examination: it is a device gives light rays with wave length above 365 nm. Hairs fluoresce with a blue-green fluorescence if infected with microsporum species. Hairs fluoresce pale green fluorescence if infected with trichophyton schoenleinii. Pityriasis versicolor fluoresce pale white yellow fluorescence. Tinea  Tinea means fungus infection.  Dermatophytes infections are classified by body regions. TINEA PEDIS (ATHLETE’S FOOT) It is tinea of the foot. Shoes promote warmth and sweating which encourage fungal growth. It is common in men.  Clinical presentations of tinea pedis 1. Classical ringworm infection as described above occurs on the dorsum of the foot. 2. Interdigital tinea pedis (toe web infection): the fourth toe web is common site. The web becomes dry, scaly, fissured or white, macerated and soggy. Itching is common. Superadded bacterial infection may complicate the infection. 3. Chronic scaly infection of the plantar surface (hyperkeratotic or moccasin type of tinea pedis): the entire sole is usually infected and covered with fine silvery white scales. The skin is pink, tender and pruritic. The hands may also be infected. It is rare to see both palms and soles infected simultaneously; rather, the pattern is infection of two feet and one hand or of two hands and one foot. Trichophyton rubrum is the usual pathogen. 4. Acute vesicular tinea pedis: is highly inflammatory infection characterized by vesicular eruption which may fuse into bullae. A second wave of vesicles may follow shortly in the same area or at distant site such as arm, chest, and along the sides of the fingers. These itchy sterile vesicles represent an allergic response to the fungus and are termed dermatophytid or id reaction. They subside when the infection is controlled.  Treatment:  Terbinafine 1% cream (Fungicidal, Lamisil) applied twice daily for 1 week.  Oral choices: Fluconazole , Itraconazole Terbinafine.  Secondary bacterial infections treated by antibiotics. Id reaction treated by topical steroids or prednisone.  TINEA CRURIS It is tinea of the groin. Common in men. Rare in children. A half moon shaped red brown plaque forms as a well-defined scaling, and sometimes advances out of the crural fold onto the thigh. Itching is common.  Treatment:  Terbinafine 1% cream (Fungicidal, Lamisil) applied twice daily for 1 week.  Oral choices: ○ Fluconazole 150 mg once weekly for 2-4 weeks. ○ Itraconazole 100 mg twice daily for 1 week. ○ Terbinafine 250mg once daily for 1-2 weeks.  TINEA CORPORIS It is tinea of the trunk, limbs and the face excluding the beard and mustache areas in men. It is present as round annular lesion as described previously in classical presentation. Treatment: as tinea cruris. Tinea manum  Itis tinea of the hand. Tinea of the dorsal aspect of the hand is similar to tinea corporis. Tinea of palmar surface has the same appearance as the dry diffuse hyperkeratotic form of tinea of the sole. Tinea of the palm is frequently associated with tinea pedis. Finger nails infection also a frequent accompaniment.  Treatment: as tinea cruris.  Tinea capitis  Itis tinea of the scalp. It occurs frequently in children between 3-7 years of age. Clinically there is cervical or occipital lymphoadenopathy. Clinical types of tinea capitis 1. Non-inflammatory black dot pattern: there is area of hair loss with hairs broken off at the follicular orifice give the appearance of black dots. 2. Inflammatory tinea capitis (kerion): there are one or multiple inflamed boggy areas of alopecia with pustules. The condition leads to scarring alopecia if not treated promptly. 3. Seborrheic dermatitis like (grey patchy) type: there is diffuse or patchy fine white adherent scales on the scalp. There are tiny pustules and/or hair stubs of broken hair. 4. Pustular type: there are discrete pustules or scabbed area without scaling or significant hair loss. 5. Favus: is infection of the scalp with Trichophyton schoenleinii. The infection characterized by the presence of yellowish cup-shaped crusts known as scutula.  Each scutulum develops round a hair. Adjacent crusts enlarge to become confluent and form a mass of yellow crusting. The condition leads to scarring alopecia if not treated early and promptly.  Treatment options: is always systemic.  Griseofulvin Side effects are headache, GI upset and photosensitivity. The drug is well absorbed after fatty meal.  Fluconazole  Terbinafine (Lamisil).  Tinea barbae  Itis fungal infection of the beard and mustache areas. Like tinea capitis, the hairs are always infected and easily removed. The hair in bacterial folliculitis resist removal (or painful on removal). Tinea begins with small group of follicular pustules. The process become confluent in time with development of a boggy erythematous kerion with dense superficial crust.  Treatment: is similar to tinea capitis. Tinea incognito (steroid modified tinea)  Itis a condition caused by wrong treatment of fungal infection with topical steroids. Topical steroids lead to disappearance of signs and symptoms (masking the infection) but the fungus is actually flourishing. Once the steroids is stopped the disease reappears and may even become more extensive and severe.  Tinaunguium (Onychomycosis): Mostly caused by Trichophyton ,Microsporum.. less Candida..fingernails & toenails. Nails become colorless/dark colored, thicken, disfigure and brittle..Diabetes  Candidiasis (Moniliasis)  The yeast like fungus Candida albicans and few other candida species are capable of producing skin, mucous membrane and internal infections.  The organism lives with the normal flora of the mouth, vaginal tract and the gut.  Pregnancy, oral contraception, antibiotic therapy, diabetes, skin maceration, topical steroid therapy, certain endocrinopathies and factors related to depression of cell mediated immunity may allow yeasts to become pathogenic. Monilial vulvovaginitis  The female present with vaginal itching and/or white thin to creamy discharge.  Treatment is by miconazole intravaginal cream or suppositories.  Fluconazole 150 mg single oral dose.  Oral candidiasis (thrush)  Candida albicans can be transmitted to the infants oral cavity during passage through the birth canal. Present as white creamy exudates or white adherent plaques. In adult it is common in diabetics, depressed cell mediated immunity, elderly, cancer, prolonged corticosteroid therapy, immunosuppression, broad spectrum antibiotic, inhalant steroid.  The presentation is similar to that in infants.  It may spread onto the skin at the angle of the mouth.  Treatment is by oral nystatin suspension, or clotrimazole or miconazole oral gel. Candida balanitis  It is common in uncircumcised penis which provides the warm, moist environment. Tender pinpoint red papules and pustules appear on the glans and shaft of penis, white exudates may be present.  Treatment is by miconazole cream twice daily for 7 days. Or single oral fluconazole 150mg capsule. Candidiasis of the skin folds (Candida intertrigo)  Occurs under pendulous breasts, between overhanging abdominal folds, in the groin and gluteal area and axillae that have heat and moisture. (Intertriginous areas are areas where skin touches skin).  Clinically there are macerated pustules and papules under apposing skin surfaces with fringe of moist scale at border. Intact pustules or papules found outside the apposing skin surfaces, this is an important diagnostic sign called satellite lesions.  Treatment by maintaining dryness. Miconazole topical cream twice daily until rash clears.  Diaper candidiasis  An artificial intertriginous area is created under wet diaper, predisposing the area to a candida infection with the characteristic red base and satellite pustules and papules.  Treatment: dryness should be maintained by changing the diaper frequently. Miconazole antifungal cream should be applied twice daily until the rash clears. Irritation treated with 1% hydrocortisone cream alternately with the antifungal cream. Finger and toe web candidiasis (interdigital candidiasis)  Any one who works in moist environment is at risk like cook, dishwasher.  White, tender macerated skin erodes revealing a pink moist base.  Treatment as above. Chronic Paronychia  Keep hands dry /Wear gloves  Oral Azoles  Antifungal solution-(high alcohol content)  +/-Broad spectrum antibiotics-cover staph/GNB  Pityriasis versicolor  Itis caused by dimorphic lipophilic yeast pityrosporum orbiculare (round form) and pityrosporum ovale (oval form). The microorganism also called malassezia furfur.  Lesions begin as multiple small circular macules and patches of various colors (white, pink or brown) that enlarge radially.  The color is uniform in each individual.  The upper trunk is most commonly affected site, then the arms, neck and abdomen.  The lesions are asymptomatic but may be itchy.  Potassium hydroxide examination of the scale shows numerous short hyphae intermixed with round spores giving an appearance of spaghetti-and-meatballs pattern.  Wood’s light examination shows irregular pale yellow-to-white fluorescence. Pale yellow fluorescence on Wood’s lamp examination.  Treatment options  Ketoconazole shampoo 2% daily application for 3 days.  Selenium sulfide suspension 2.5% (Selsun) applied for 10 minutes every day for 7 consecutive days.  Itraconazole 200mg once daily for 7 days.  Fluconazole 300mg single oral dose.  Ketoconazole 400mg single oral dose.  Head dundruff, Seborrheic dermatitis.  White & Black Piedra..Trichosporon spp., Soft to hard nodules. scalp hair & hair shaft , skin face , any body part.  Blasmycosis: Blastomyces dermatitidis & Histoplasmosis : Histoplasma capsulatum.. Dimorphic Fungi.. Soil..Spore Inhalation.. Respiratory infection.. Systemic Infection.. Complications: Skin ulcerations/lesions Granulomas..causes severe damages..common USA, Canada  Aspergillus & Cryptococcus spp. Rare cause localised skin or nail.. THANK YOU