Four Criteria of a Neurotransmitter

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12 Questions

What would be the effect on serotonin levels if you inhibit SERT?

Serotonin levels would increase in the extracellular state

What is the role of acetylcholinesterase (AChE) in neuronal signaling?

AChE breaks down acetylcholine after release from synaptic vesicles

What is the fate of choline after it is transported back into the neuron by choline transporter (CHT)?

It is converted back to acetylcholine

How does Aricept (an acetylcholinesterase inhibitor) impact neuronal signaling?

It inhibits the breakdown of acetylcholine, leading to increased levels

What role do glial cells (astrocytes) play in neurotransmitter recycling?

Astrocytes take up neurotransmitters like GABA, recycle them, and provide precursors for neurotransmitter synthesis

What is a requirement for a substance to be classified as a neurotransmitter?

It must be released via exocytosis from vesicles

Which neurotransmitter is reduced in Alzheimer's disease?

Acetylcholine

What differentiates classic small molecule neurotransmitters from neuropeptides?

Duration of action

Which neurotransmitter is also known as noradrenaline?

Norepinephrine

What is the role of monoamine oxidase (MAO) in neurotransmission?

Breakdown of monoamine neurotransmitters intracellularly

Which neurotransmitter is most common as an inhibitory transmitter throughout the central nervous system (CNS) and body?

GABA

What do dopamine neurons not express in the biosynthetic pathway of catecholamines?

Final 2 enzymes in the pathway

This quiz covers the four main criteria of a neurotransmitter, including its synthesis in the presynaptic neuron, release via exocytosis, ability to mimic the action of endogenous transmitters, and specificity for certain receptors. Test your knowledge on neurotransmitters with this quiz!

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