Podcast
Questions and Answers
Which enzyme catalyzes the reaction that converts glutamate into GABA?
Which enzyme catalyzes the reaction that converts glutamate into GABA?
Where is GABA primarily stored?
Where is GABA primarily stored?
Which transporters are responsible for removing GABA from the synaptic cleft?
Which transporters are responsible for removing GABA from the synaptic cleft?
What is the primary function of GABA in the brain?
What is the primary function of GABA in the brain?
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What vitamin derivative acts as a cofactor in GABA synthesis?
What vitamin derivative acts as a cofactor in GABA synthesis?
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Study Notes
GABA Synthesis and Function
- Glutamate is converted into GABA through the action of glutamic acid decarboxylase (GAD).
- GABA is primarily stored in synaptic vesicles located within GABAergic neurons.
- GABA removal from the synaptic cleft is facilitated by two types of transporters: GABA transporters (GATs) and the sodium-dependent transporters.
- The primary function of GABA in the brain is as an inhibitory neurotransmitter, helping to regulate neuronal excitability and maintain balance in neural circuits.
- Vitamin B6, specifically its derivative pyridoxal phosphate, acts as a cofactor in the synthesis of GABA from glutamate.
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Description
Test your knowledge on GABA synthesis and its role as a neurotransmitter. Learn about the key enzymes involved, the role of vitamin B6, and the implications of GABA deficiency. Discover how GABA is synthesized and stored in neurons.
