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Questions and Answers
Which enzyme is responsible for the synthesis of acetylcholine?
Which enzyme is responsible for the synthesis of acetylcholine?
- Monoamine oxidase (MAO)
- Acetylcholinesterase (AChE)
- Choline acetyltransferase (ChAT) (correct)
- Tyrosine hydroxylase (TH)
What happens to acetylcholine after it is released into the synaptic cleft?
What happens to acetylcholine after it is released into the synaptic cleft?
- It is immediately reabsorbed by the presynaptic neuron
- It diffuses out of the synaptic cleft
- It is converted to norepinephrine
- It binds to acetylcholine receptors on the postsynaptic membrane (correct)
Which enzyme degrades acetylcholine in the synaptic cleft?
Which enzyme degrades acetylcholine in the synaptic cleft?
- Choline acetyltransferase (ChAT)
- Acetylcholinesterase (AChE) (correct)
- Monoamine oxidase (MAO)
- Tyrosine hydroxylase (TH)
Which two products result from the degradation of acetylcholine?
Which two products result from the degradation of acetylcholine?
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What happens to the products of acetylcholine degradation?
What happens to the products of acetylcholine degradation?
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What is the role of VACIT in the Acetylcholine cycle?
What is the role of VACIT in the Acetylcholine cycle?
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Study Notes
Synthesis of Acetylcholine
- Acetylcholine is synthesized from choline and acetyl coenzyme A (acetyl-CoA) by the enzyme choline acetyltransferase (ChAT).
Release of Acetylcholine
- Acetylcholine is released from the presynaptic nerve terminal into the synaptic cleft.
- Acetylcholine is transported into synaptic vesicles via VACIT.
- Acetylcholine is released from vesicles into the synaptic cleft by nerve impulse.
Binding of Acetylcholine
- Acetylcholine binds to the acetylcholine receptors on the postsynaptic membrane.
- Acetylcholine binds to receptors on muscle fibers.
Degradation of Acetylcholine
- Acetylcholine is degraded by the enzyme acetylcholinesterase (AChE).
- The products of degradation are choline and acetate.
Recycling of Products
- Choline is recycled back into the presynaptic neuron for the synthesis of new acetylcholine.
- Acetate is recycled by the nerve terminal.
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Description
This diagram illustrates the process of acetylcholine synthesis from choline and acetyl-CoA, its release and binding to receptors, and its degradation by acetylcholinesterase. Learn about the key steps involved in this process.
