Questions and Answers
How does particle size reduction affect the effective surface area of the drug?
It increases the effective surface area enormously
What is the impact of micronized particle size on the absorption of low aqueous solubility drugs?
It increases absorption rates
Why might a disintegrant be added to the formulation of poorly soluble drugs?
To ensure rapid disintegration of the tablet and release of the particles
What is a limitation of extensive particle size reduction for poorly soluble, hydrophobic drugs?
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Why might increased rate of dissolution be undesirable for certain drugs like penicillin G and erythromycin?
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