Drug Dissolution Rate Model Quiz
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Questions and Answers

Which factor directly affects the rate of drug dissolution according to the Noyes-Whitney equation?

  • Drug particle size
  • Concentration gradient between the solid surface and bulk solution
  • Diffusion coefficient of the drug in the dissolution medium
  • All of the above (correct)

    • How can the dissolution rate of a poorly soluble drug be increased?

  • By increasing the particle size of the drug
  • By decreasing the diffusion coefficient of the drug
  • By using a more viscous dissolution medium
  • By forming an inclusion complex with cyclodextrins (correct)

    • Which statement is true regarding the effect of surface area on drug dissolution rate?

  • Decreasing the surface area increases the dissolution rate
  • Increasing the surface area has no effect on the dissolution rate
  • Increasing the surface area increases the dissolution rate (correct)
  • Increasing the surface area decreases the dissolution rate

    • What is the relationship between the diffusion coefficient of a drug and the viscosity of the dissolution medium?

    <p>The diffusion coefficient is inversely proportional to the viscosity</p> Signup and view all the answers

    Which technique can be used to increase the surface area of a poorly soluble drug?

    <p>Micronization</p> Signup and view all the answers

    What is the purpose of forming inclusion complexes with cyclodextrins for poorly soluble drugs?

    <p>To improve the drug's solubility and dissolution rate</p> Signup and view all the answers

    According to the Noyes-Whitney equation, the rate of drug dissolution is directly proportional to which of the following?

    <p>The difference between drug concentration in the bulk solution and saturation solubility</p> Signup and view all the answers

    Which of the following techniques could be used to enhance the dissolution rate of a poorly soluble drug?

    <p>Forming an inclusion complex with cyclodextrins</p> Signup and view all the answers

    What is the primary role of the unstirred solvent layer in the dissolution process?

    <p>To provide a barrier for drug molecules to diffuse through</p> Signup and view all the answers

    If the diffusion coefficient of a drug in the unstirred layer decreases, what effect would it have on the dissolution rate?

    <p>The dissolution rate would decrease</p> Signup and view all the answers

    What is the main driving force for the dissolution process described in the Noyes-Whitney equation?

    <p>The concentration gradient across the unstirred layer</p> Signup and view all the answers

    Which of the following statements is true regarding the dissolution process described in the text?

    <p>The drug molecules dissolve at the particle surface, then diffuse through the unstirred layer</p> Signup and view all the answers

    Which statement about drug dissolution rates is correct?

    <p>Hydrophilic drugs generally have faster dissolution rates in aqueous environments compared to lipophilic drugs.</p> Signup and view all the answers

    How does pH affect the solubility of basic drugs?

    <p>Basic drugs dissolve slower and are mostly ionized in the acidic pH of the stomach.</p> Signup and view all the answers

    What property of drugs affects their ability to cross biological membranes?

    <p>Both lipophilicity and ionization state</p> Signup and view all the answers

    Which statement about acidic drugs is correct?

    <p>Acidic drugs dissolve slower and are mostly unionized in the stomach, while they dissolve faster and are mostly ionized in the small intestine.</p> Signup and view all the answers

    Which factors can affect the rate and extent of drug absorption?

    <p>All of the above</p> Signup and view all the answers

    How can the formation of inclusion complexes with cyclodextrins affect drug solubility?

    <p>It can increase the solubility of lipophilic drugs by encapsulating them in the hydrophobic cavity of cyclodextrins.</p> Signup and view all the answers

    Study Notes

    Drug Dissolution and Absorption

    • The rate of drug dissolution is directly affected by the surface area of the drug according to the Noyes-Whitney equation.
    • Increasing the surface area of a poorly soluble drug can increase its dissolution rate.
    • The statement "an increase in surface area results in an increase in dissolution rate" is true regarding the effect of surface area on drug dissolution rate.
    • The diffusion coefficient of a drug is inversely proportional to the viscosity of the dissolution medium.
    • Techniques to increase the surface area of a poorly soluble drug include milling, micronization, and nanoparticle formation.
    • The purpose of forming inclusion complexes with cyclodextrins for poorly soluble drugs is to increase their solubility and bioavailability.
    • According to the Noyes-Whitney equation, the rate of drug dissolution is directly proportional to the surface area of the drug and the drug concentration gradient, and inversely proportional to the thickness of the unstirred solvent layer.
    • Techniques to enhance the dissolution rate of a poorly soluble drug include milling, micronization, nanoparticle formation, and formation of inclusion complexes with cyclodextrins.
    • The primary role of the unstirred solvent layer in the dissolution process is to provide a barrier to drug dissolution.
    • If the diffusion coefficient of a drug in the unstirred layer decreases, the dissolution rate will decrease.
    • The main driving force for the dissolution process described in the Noyes-Whitney equation is the concentration gradient of the drug.
    • The statement "the dissolution rate of a drug is directly proportional to the surface area of the drug and the drug concentration gradient, and inversely proportional to the thickness of the unstirred solvent layer" is true regarding the dissolution process.
    • The statement "an increase in surface area results in an increase in dissolution rate" is correct regarding drug dissolution rates.
    • The solubility of basic drugs increases with decreasing pH.
    • The property of drugs that affects their ability to cross biological membranes is lipophilicity.
    • The statement "the solubility of acidic drugs increases with increasing pH" is correct.
    • Factors that can affect the rate and extent of drug absorption include solubility, surface area, ionization, and gastrointestinal transit time.
    • The formation of inclusion complexes with cyclodextrins can increase drug solubility and bioavailability.

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    Description

    Test your understanding of drug dissolution rate models, with a focus on drugs with limited aqueous solubility, Noyes and Whitney dissolution model, and factors affecting drug absorption processes.

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