Podcast
Questions and Answers
Which factor directly affects the rate of drug dissolution according to the Noyes-Whitney equation?
Which factor directly affects the rate of drug dissolution according to the Noyes-Whitney equation?
- Drug particle size
- Concentration gradient between the solid surface and bulk solution
- Diffusion coefficient of the drug in the dissolution medium
- All of the above (correct)
How can the dissolution rate of a poorly soluble drug be increased?
How can the dissolution rate of a poorly soluble drug be increased?
- By increasing the particle size of the drug
- By decreasing the diffusion coefficient of the drug
- By using a more viscous dissolution medium
- By forming an inclusion complex with cyclodextrins (correct)
Which statement is true regarding the effect of surface area on drug dissolution rate?
Which statement is true regarding the effect of surface area on drug dissolution rate?
- Decreasing the surface area increases the dissolution rate
- Increasing the surface area has no effect on the dissolution rate
- Increasing the surface area increases the dissolution rate (correct)
- Increasing the surface area decreases the dissolution rate
What is the relationship between the diffusion coefficient of a drug and the viscosity of the dissolution medium?
What is the relationship between the diffusion coefficient of a drug and the viscosity of the dissolution medium?
Which technique can be used to increase the surface area of a poorly soluble drug?
Which technique can be used to increase the surface area of a poorly soluble drug?
What is the purpose of forming inclusion complexes with cyclodextrins for poorly soluble drugs?
What is the purpose of forming inclusion complexes with cyclodextrins for poorly soluble drugs?
According to the Noyes-Whitney equation, the rate of drug dissolution is directly proportional to which of the following?
According to the Noyes-Whitney equation, the rate of drug dissolution is directly proportional to which of the following?
Which of the following techniques could be used to enhance the dissolution rate of a poorly soluble drug?
Which of the following techniques could be used to enhance the dissolution rate of a poorly soluble drug?
What is the primary role of the unstirred solvent layer in the dissolution process?
What is the primary role of the unstirred solvent layer in the dissolution process?
If the diffusion coefficient of a drug in the unstirred layer decreases, what effect would it have on the dissolution rate?
If the diffusion coefficient of a drug in the unstirred layer decreases, what effect would it have on the dissolution rate?
What is the main driving force for the dissolution process described in the Noyes-Whitney equation?
What is the main driving force for the dissolution process described in the Noyes-Whitney equation?
Which of the following statements is true regarding the dissolution process described in the text?
Which of the following statements is true regarding the dissolution process described in the text?
Which statement about drug dissolution rates is correct?
Which statement about drug dissolution rates is correct?
How does pH affect the solubility of basic drugs?
How does pH affect the solubility of basic drugs?
What property of drugs affects their ability to cross biological membranes?
What property of drugs affects their ability to cross biological membranes?
Which statement about acidic drugs is correct?
Which statement about acidic drugs is correct?
Which factors can affect the rate and extent of drug absorption?
Which factors can affect the rate and extent of drug absorption?
How can the formation of inclusion complexes with cyclodextrins affect drug solubility?
How can the formation of inclusion complexes with cyclodextrins affect drug solubility?
Study Notes
Drug Dissolution and Absorption
- The rate of drug dissolution is directly affected by the surface area of the drug according to the Noyes-Whitney equation.
- Increasing the surface area of a poorly soluble drug can increase its dissolution rate.
- The statement "an increase in surface area results in an increase in dissolution rate" is true regarding the effect of surface area on drug dissolution rate.
- The diffusion coefficient of a drug is inversely proportional to the viscosity of the dissolution medium.
- Techniques to increase the surface area of a poorly soluble drug include milling, micronization, and nanoparticle formation.
- The purpose of forming inclusion complexes with cyclodextrins for poorly soluble drugs is to increase their solubility and bioavailability.
- According to the Noyes-Whitney equation, the rate of drug dissolution is directly proportional to the surface area of the drug and the drug concentration gradient, and inversely proportional to the thickness of the unstirred solvent layer.
- Techniques to enhance the dissolution rate of a poorly soluble drug include milling, micronization, nanoparticle formation, and formation of inclusion complexes with cyclodextrins.
- The primary role of the unstirred solvent layer in the dissolution process is to provide a barrier to drug dissolution.
- If the diffusion coefficient of a drug in the unstirred layer decreases, the dissolution rate will decrease.
- The main driving force for the dissolution process described in the Noyes-Whitney equation is the concentration gradient of the drug.
- The statement "the dissolution rate of a drug is directly proportional to the surface area of the drug and the drug concentration gradient, and inversely proportional to the thickness of the unstirred solvent layer" is true regarding the dissolution process.
- The statement "an increase in surface area results in an increase in dissolution rate" is correct regarding drug dissolution rates.
- The solubility of basic drugs increases with decreasing pH.
- The property of drugs that affects their ability to cross biological membranes is lipophilicity.
- The statement "the solubility of acidic drugs increases with increasing pH" is correct.
- Factors that can affect the rate and extent of drug absorption include solubility, surface area, ionization, and gastrointestinal transit time.
- The formation of inclusion complexes with cyclodextrins can increase drug solubility and bioavailability.
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Description
Test your understanding of drug dissolution rate models, with a focus on drugs with limited aqueous solubility, Noyes and Whitney dissolution model, and factors affecting drug absorption processes.
