Podcast
Questions and Answers
What is the main purpose of a solid dispersion in pharmaceuticals?
What is the main purpose of a solid dispersion in pharmaceuticals?
- To reduce the bioavailability of the drug
- To increase the crystallinity of the drug
- To alter the solubility and solution rate of the drug (correct)
- To change the chemical structure of the drug
In a solid dispersion, what happens to the physical state of the drug particles?
In a solid dispersion, what happens to the physical state of the drug particles?
- They remain in a crystalline state
- They become more hydrophobic
- They shift to a liquid state
- They change from a crystalline state to an amorphous state (correct)
Why is obtaining the correct polymorph or hydrate of a pharmaceutical substance important?
Why is obtaining the correct polymorph or hydrate of a pharmaceutical substance important?
- It speeds up the drug dissolution process
- It reduces the drug's solubility in water
- It can affect solubility and bioavailability (correct)
- It has no impact on bioavailability
What happens when a solid dispersion is added to water?
What happens when a solid dispersion is added to water?
How does solid dispersion aid in drug dissolution without chemical modification of the drug?
How does solid dispersion aid in drug dissolution without chemical modification of the drug?
What is the significance of the contact angle (θ) in determining wetting of powders?
What is the significance of the contact angle (θ) in determining wetting of powders?
How does the presence of hydrophobic drugs impact the wetting and solubility of solid drugs?
How does the presence of hydrophobic drugs impact the wetting and solubility of solid drugs?
What role do surfactants play in improving wettability of powders?
What role do surfactants play in improving wettability of powders?
What does a contact angle of 0° signify in terms of wetting?
What does a contact angle of 0° signify in terms of wetting?
How is solubility defined in relation to a drug and a solvent?
How is solubility defined in relation to a drug and a solvent?
How does solubility impact the bioavailability of a drug?
How does solubility impact the bioavailability of a drug?
How does particle size reduction impact drug dissolution?
How does particle size reduction impact drug dissolution?
In what scenario would dissolution be the rate-limiting step in drug absorption?
In what scenario would dissolution be the rate-limiting step in drug absorption?
What role does particle size reduction play in the transport of substances across the intestinal wall?
What role does particle size reduction play in the transport of substances across the intestinal wall?
How do very small particles in the nanometer range impact absorption into the systemic circulation?
How do very small particles in the nanometer range impact absorption into the systemic circulation?
What happens to drug bioavailability if dissolution is the rate-limiting step in absorption?
What happens to drug bioavailability if dissolution is the rate-limiting step in absorption?
Why is the particle size of a drug considered important?
Why is the particle size of a drug considered important?
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