Biopharmaceutical Importance of Particle Size
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Questions and Answers

What is the main purpose of a solid dispersion in pharmaceuticals?

  • To reduce the bioavailability of the drug
  • To increase the crystallinity of the drug
  • To alter the solubility and solution rate of the drug (correct)
  • To change the chemical structure of the drug

    • In a solid dispersion, what happens to the physical state of the drug particles?

  • They remain in a crystalline state
  • They become more hydrophobic
  • They shift to a liquid state
  • They change from a crystalline state to an amorphous state (correct)

    • Why is obtaining the correct polymorph or hydrate of a pharmaceutical substance important?

  • It speeds up the drug dissolution process
  • It reduces the drug's solubility in water
  • It can affect solubility and bioavailability (correct)
  • It has no impact on bioavailability

    • What happens when a solid dispersion is added to water?

    <p>The solid carrier dissolves, leaving the drug dispersed as fine particles</p> Signup and view all the answers

    How does solid dispersion aid in drug dissolution without chemical modification of the drug?

    <p>By molecularly dispersing the drug in a solid solvent</p> Signup and view all the answers

    What is the significance of the contact angle (θ) in determining wetting of powders?

    <p>Contact angles less than 90° indicate good wetting, while angles greater than 90° suggest problems with wetting.</p> Signup and view all the answers

    How does the presence of hydrophobic drugs impact the wetting and solubility of solid drugs?

    <p>Hydrophobic drugs are not readily wetted and have low solubility.</p> Signup and view all the answers

    What role do surfactants play in improving wettability of powders?

    <p>Surfactants enhance wettability by decreasing the contact angle.</p> Signup and view all the answers

    What does a contact angle of 0° signify in terms of wetting?

    <p>Complete wetting</p> Signup and view all the answers

    How is solubility defined in relation to a drug and a solvent?

    <p>Solubility is the maximum quantity of drug dissolved in a given volume of a solvent solution.</p> Signup and view all the answers

    How does solubility impact the bioavailability of a drug?

    <p>Higher solubility usually results in increased bioavailability.</p> Signup and view all the answers

    How does particle size reduction impact drug dissolution?

    <p>Increases drug dissolution by increasing exposure of the drug surface to the solvent</p> Signup and view all the answers

    In what scenario would dissolution be the rate-limiting step in drug absorption?

    <p>When drug dissolution is slow due to physicochemical properties or formulation factors</p> Signup and view all the answers

    What role does particle size reduction play in the transport of substances across the intestinal wall?

    <p>Facilitates transport by increasing exposure of particles to the solvent</p> Signup and view all the answers

    How do very small particles in the nanometer range impact absorption into the systemic circulation?

    <p>Enhance absorption by facilitating transportation through enterocytes</p> Signup and view all the answers

    What happens to drug bioavailability if dissolution is the rate-limiting step in absorption?

    <p>Bioavailability decreases</p> Signup and view all the answers

    Why is the particle size of a drug considered important?

    <p>To increase dissolution by increasing exposure of the drug surface to the solvent</p> Signup and view all the answers

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