(2019) Pain: NSAIDs and Analgesic Ladder

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18 Questions

What was the major mechanism of action of all NSAIDs demonstrated by Vane and co-workers?

Inhibition of prostaglandin synthesis

Which compound obtained from willow bark led to the discovery of aspirin in 1899?

Salicylic acid

What strategy was proposed by WHO to provide adequate pain relief for cancer patients?

Around-the-clock pain relief

What is the main difference between NSAIDs and opioids in terms of analgesic strength?

Opioids are stronger analgesics compared to NSAIDs

Which enzyme is responsible for the synthesis of leukotrienes in the prostaglandin synthesis pathway?

Lipoxygenase (LOX)

What is the IASP definition of pain based on the provided text?

An unpleasant sensory and emotional experience associated with or resembling tissue damage

Which enzymes are inhibited by NSAIDs to reduce prostaglandin synthesis?

COX-1

According to the WHO Analgesic Ladder Strategy, what is the recommended step for moderate to severe pain?

Combining NSAIDs with opioids from the beginning

How do weaker analgesics differ from opioids in terms of pain management effectiveness?

Opioids are more potent in managing severe pain than weaker analgesics

Which class of analgesics primarily target COX-2 to reduce inflammation and pain?

Selective COX-2 inhibitors

What is a key difference between the mechanism of action of NSAIDs and opioids in pain management?

Opioids act directly on central nervous system receptors, while NSAIDs reduce inflammation by inhibiting COX enzymes

What is the mechanism by which NSAIDs exert their anti-inflammatory effect?

Blocking COX enzymes selectively

Which prostaglandin is primarily responsible for vascular endothelium vasodilation and inhibition of platelet aggregation?

PGI2

Which class of NSAIDs includes aspirin, ibuprofen, and naproxen?

Non-selective COX inhibitors

What is the primary effect of NSAIDs on platelet function?

Inhibiting platelet aggregation

Which event is a common consequence of NSAID-induced deficiency of prostaglandins (PGs)?

Prolongation of bleeding time

Which prostaglandin is primarily responsible for smooth muscle contraction throughout the body and inhibition of gastric acid secretion?

PGE2

What is the main difference between non-selective and selective COX-2 inhibitors in terms of COX enzyme inhibition?

Non-selective inhibitors block both COX enzymes, while selective inhibitors block COX-1 only.

Learn about the ascending pain pathway, NSAIDs introduction, weaker analgesics, WHO Analgesic Ladder Strategy, and the history of NSAIDs from willow bark to sodium salicylate. Explore the use of non-steroidal anti-inflammatory drugs in pain management.

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