8 Questions
What type of gene segments are present in inherited antigen receptor gene loci in the germline?
Exons and introns
How is combinatorial diversity achieved in generating receptors of different specificities?
Rearrangement combinations of V, D, and J gene segments
Where do B cells undergo VDJ recombination?
Bone marrow
Which statement is correct about Natural Killer T-cells (NK-T cells)?
Express alpha beta chain AND surface molecules found on Natural Killer cells
What is an unusual property of gamma delta T cells?
Gamma delta TCRs recognize antigens not displayed on MHC molecules
What percentage of T cells in the body express gamma delta chains instead of alpha and beta chains?
5-10%
Which gene loci house the gamma and delta gene segments for gamma delta T cells?
Gamma gene locus, chromosome 7; delta gene locus, chromosome 14
What type of antigens can gamma delta TCRs recognize?
Protein and non-protein antigens
Test your knowledge on introns in immunoglobulin genes, combinatorial diversity, and gene segment rearrangement in the immune system. Learn about the role of introns, mRNA processing, and the generation of receptors with different specificities.
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