Podcast
Questions and Answers
What is the consequence of adding G after CGA in the sequence GCG.CGA?
What is the consequence of adding G after CGA in the sequence GCG.CGA?
- The sequence changes to GCG.CGA.UAA and translates to Ala.Arg.Stop
- The sequence changes to GCG.CGA.GAA.UA and translates to Ala.Arg.Glu (correct)
- The sequence changes to GCG.CGA.AUA and translates to Ala.Arg.Ile
- The sequence changes to GCG.CGA.CAA.UA and translates to Ala.Arg.Gln
What happens when any heavy chain associates with any light chain in the generation of diversity?
What happens when any heavy chain associates with any light chain in the generation of diversity?
- It creates further variability (correct)
- It results in identical antibody production
- It leads to a decrease in the number of different heavy and light chains
- It reduces the antibody diversity
When do the processes of random assortment of heavy and light chains occur?
When do the processes of random assortment of heavy and light chains occur?
- Before the cell encounters antigen (correct)
- During somatic hypermutation
- After the B cell undergoes isotype switching
- After the B cell encounters antigen
What type of antibody is produced by the B cell progeny as its first antibody?
What type of antibody is produced by the B cell progeny as its first antibody?
What mediates the process of somatic hypermutation?
What mediates the process of somatic hypermutation?
Which enzyme is involved in the process of isotype switch?
Which enzyme is involved in the process of isotype switch?
What happens in the absence of AID?
What happens in the absence of AID?
What happens to the B cell if it possesses increased binding affinity due to somatic hypermutation?
What happens to the B cell if it possesses increased binding affinity due to somatic hypermutation?
Which type of antigen does not require somatic hypermutation in the responding B cell?
Which type of antigen does not require somatic hypermutation in the responding B cell?
What is the role of the enzymes RAG-1 and RAG-2 in the generation of diversity?
What is the role of the enzymes RAG-1 and RAG-2 in the generation of diversity?
What is the difference between heavy chain genes and light chain genes?
What is the difference between heavy chain genes and light chain genes?
Which enzymes are involved in the random recombination of VJ and VDJ gene segments?
Which enzymes are involved in the random recombination of VJ and VDJ gene segments?
Which process involves DNA cleavage and the addition or deletion of nucleotides to create a joint?
Which process involves DNA cleavage and the addition or deletion of nucleotides to create a joint?
What is the function of terminal deoxynucleotidyl transferase (TdT) in junctional diversity?
What is the function of terminal deoxynucleotidyl transferase (TdT) in junctional diversity?
What would happen if there is an absence of RAG-1 and RAG-2 enzymes?
What would happen if there is an absence of RAG-1 and RAG-2 enzymes?
What is the main factor contributing to the theoretical diversity of gene combinations?
What is the main factor contributing to the theoretical diversity of gene combinations?
What is the role of exonuclease in junctional diversity?
What is the role of exonuclease in junctional diversity?
What happens if there is an absence of terminal deoxynucleotidyl transferase (TdT) in junctional diversity?
What happens if there is an absence of terminal deoxynucleotidyl transferase (TdT) in junctional diversity?
Which enzyme products are responsible for the separation, shuffling, and rejoining of VDJ genes?
Which enzyme products are responsible for the separation, shuffling, and rejoining of VDJ genes?
How does the generation of germline diversity occur?
How does the generation of germline diversity occur?
