13 Questions
What is the effect of the CD40 ligand on activated T cells binding to CD40 on APCs?
Activates APCs to express more B7 and secrete cytokines (IL-12)
Which scenario represents an example of autocrine stimulation?
IL-2 produced by antigen-stimulated T cells acting on the same T cell
What happens to memory T cells after a typical acute viral infection is resolved?
Memory T cells survive long after the infection is eradicated
Which CD4 effector cell is associated with eosinophils, intestinal worms, and allergies?
Th2 cell (type 2 helper T cells)
What is different about the IL-2 receptor on a naïve T cell compared to an activated T cell?
Activated T cells lack the alpha chain of the IL-2 receptor
What part of the secreted immunoglobulin IgG can bind cell surface receptors to initiate cell killing?
Fc region
During developing B cell receptor editing, what genetic elements are reactivated?
RAG genes
What process allows an immature B cell to express a different Ig receptor that is not self-reactive?
Receptor editing
Where do B cells expressing IgM and IgD migrate to respond to their specific antigens?
Peripheral lymphoid tissues
What cells interact with B cells to help them develop into plasma cells that secrete antibodies?
Follicular helper T (TFH) cells
In the T cell signal transduction pathway, what phosphorylates the CD3 and zeta chains?
ZAP-70 kinase
What is necessary for the initiation of the activation phase in T cells?
Antigen binding in MHC
What is the role of the Fc region in a secreted immunoglobulin like IgG?
To bind cell surface receptors
Learn about the effector region of secreted immunoglobulins like IgG and how the Fc region can bind to cell surface receptors to initiate cell killing. Understand the process of receptor editing in developing B cells, where unsuccessful cells recombine light chains to try again for positive and negative selection.
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