Cephalosporins Mechanism and Characteristics
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Questions and Answers

Which structural characteristic is essential for the mechanism of cephalosporins?

  • The presence of a phenolic group
  • A halogen substituent
  • The $eta$-lactam ring (correct)
  • A linear carbon chain

    • What role does the acetoxy substituent play in cephalosporins?

  • It decreases $eta$-lactamase resistance
  • It enhances the acid stability (correct)
  • It facilitates Gram-positive activity
  • It increases hydrophobicity

    • Which modification at position 7 could alter the spectrum of cephalosporins?

  • 3-Acetoxymethyl side chain
  • Acetoxy substitution
  • Methyl substitution
  • 7-Acylamino side chain (correct)

    • What is one characteristic of certain generations of cephalosporins regarding their activity against bacteria?

    <p>They are resistant to $eta$-lactamases</p> Signup and view all the answers

    Which of the following is the main pharmacological feature of cephalosporins that allows some to penetrate the cerebrospinal fluid (CSF)?

    <p>The presence of double bonds</p> Signup and view all the answers

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