28 Questions
Which of the following antibiotics have activities against Pseudomonas?
Piperacillin, Ticarcillin, Carbenicillin and Azlocillin
What is a common adverse effect of broad-spectrum penicillins?
Antibiotic-associated colitis
What is the mechanism of action of Cephalosporins?
Inhibition of cell wall synthesis by blocking transpeptidation of peptidoglycan
What is a characteristic of Cephalosporins?
Broader spectrum of antibacterial activities
Which of the following is NOT classified as a first-generation Cephalosporin?
Ceftriaxone
What is a characteristic of First-Generation Cephalosporins?
Inactive against enterococci
What is the primary route of administration for faecalis?
IV
What is a common adverse effect of faecalis?
Ototoxicity
What is the mechanism of action of daptomycin?
Creating artificial pores on the membrane
What is a contraindication for the use of daptomycin?
Pneumonia
What is a rare but severe allergic reaction to faecalis?
Anaphylaxis
What is a characteristic of Second-Generation Cephalosporins?
They have extended activity against Gram -ve bacteria while retaining activity against Gram +ve organisms
Which of the following Cephalosporins has good activity against Pseudomonas spp?
Ceftazidime
What is a characteristic of Fourth-Generation Cephalosporins?
They have good activity against Pseudomonas, enterobacteria, as well as Staph, Strept, haemophilus, and Neisseria
What is a use of Third-Generation Cephalosporins?
Gram -ve infections
What is a common side effect of Cephalosporins?
Local irritation after intramuscular injection
What is a characteristic of Fifth-Generation Cephalosporins?
They are active against MRSA, enterococci, and G- organisms
What is the mechanism of action of macrolides?
Binding to bacterial 50S ribosomes and inhibiting protein synthesis
Which of the following is a common adverse effect of aminoglycosides?
Nephrotoxicity
What is the clinical use of beta lactams with penicillins?
Treatment of enterococcal endocarditis
What is the common feature of the antibacterial spectrum of macrolides and penicillins?
Similar but not identical spectrum
Which of the following is an example of a macrolide antibiotic?
Erythromycin
What is the effect of bacteriostatic antibiotics on bacterial growth?
They stop bacterial growth
Which of the following organisms is NOT typically targeted by the antibiotics mentioned?
Candida
What is the mechanism of action of chloramphenicol?
Inhibiting 50S ribosomal subunit
What is a common adverse effect of chloramphenicol?
Nausea and vomiting
What is a clinical use of linzolid?
Treating bacterial infections caused by Staph, Strept, and Enterococci
What is the effect of chloramphenicol on certain infections?
It predisposes to them
Learn about the characteristics, activities, and adverse effects of penicillins and cephalosporins, including Ticarcillin, Piperacillin, and Carbenicillin.
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