Topic 1 The Human Body.docx

Topic 1: THE HUMAN BODY ***Blood Pressure*** *A proficiency in anatomy and physiology is fundamental to any career in the health professions. (credit: Bryan Mason/flickr)* An understanding of anatomy and physiology is not only fundamental to any career in the health professions, but it can also b...

Topic 1: THE HUMAN BODY ***Blood Pressure*** *A proficiency in anatomy and physiology is fundamental to any career in the health professions. (credit: Bryan Mason/flickr)* An understanding of anatomy and physiology is not only fundamental to any career in the health professions, but it can also benefit your own health. Familiarity with the human body can help you make healthful choices and prompt you to take appropriate action when signs of illness arise. Your knowledge in this field will help you understand news about nutrition, medications, medical devices, and procedures and help you understand genetic or infectious diseases. At some point, everyone will have a problem with some aspect of his or her body and your knowledge can help you to be a better parent, spouse, partner, friend, colleague, or caregiver **INTRODUCTION** Human **anatomy** is the scientific study of the body's structures. Some of these structures are very small and can only be observed and analyzed with the assistance of a microscope. Other larger structures can readily be seen, manipulated, measured, and weighed. The word "anatomy" comes from a Greek root that means "to cut apart." Human anatomy was first studied by observing the exterior of the body and observing the wounds of soldiers and other injuries. Later, physicians were allowed to dissect bodies of the dead to augment their knowledge. When a body is dissected, its structures are cut apart in order to observe their physical attributes and their relationships to one another. Dissection is still used in medical schools, anatomy courses, and in pathology labs. In order to observe structures in living people, however, a number of imaging techniques have been developed. These techniques allow clinicians to visualize structures inside the living body such as a cancerous tumor or a fractured bone. Like most scientific disciplines, anatomy has areas of specialization. **Gross anatomy** is the study of the larger structures of the body, those visible without the aid of magnification. Macro- means "large," thus, gross anatomy is also referred to as macroscopic anatomy. In contrast, micro- means "small," and **microscopic anatomy** is the study of structures that can be observed only with the use of a microscope or other magnification devices. Microscopic anatomy includes cytology, the study of cells and histology, the study of tissues. As the technology of microscopes has advanced, anatomists have been able to observe smaller and smaller structures of the body, from slices of large structures like the heart, to the three-dimensional structures of large molecules in the body. Anatomists take two general approaches to the study of the body's structures: regional and systemic. **Regional anatomy** is the study of the interrelationships of all of the structures in a specific body region, such as the abdomen. Studying regional anatomy helps us appreciate the interrelationships of body structures, such as how muscles, nerves, blood vessels, and other structures work together to serve a particular body region. In contrast, **systemic anatomy** is the study of the structures that make up a discrete body system---that is, a group of structures that work together to perform a unique body function. For example, a systemic anatomical study of the muscular system would consider all of the skeletal muscles of the body. Whereas anatomy is about structure, physiology is about function. Human **physiology** is the scientific study of the chemistry and physics of the structures of the body and the ways in which they work together to support the functions of life. Much of the study of physiology centers on the body's tendency toward homeostasis. **Homeostasis** is the state of steady internal conditions maintained by living things. The study of physiology certainly includes observation, both with the naked eye and with microscopes, as well as manipulations and measurements. However, current advances in physiology usually depend on carefully designed laboratory experiments that reveal the functions of the many structures and chemical compounds that make up the human body. Like anatomists, physiologists typically specialize in a particular branch of physiology. For example, neurophysiology is the study of the brain, spinal cord, and nerves and how these work together to perform functions as complex and diverse as vision, movement, and thinking. Physiologists may work from the organ level (exploring, for example, what different parts of the brain do) to the molecular level (such as exploring how an electrochemical signal travels along nerves). Form is closely related to function in all living things. For example, the thin flap of your eyelid can snap down to clear away dust particles and almost instantaneously slide back up to allow you to see again. At the microscopic level, the arrangement and function of the nerves and muscles that serve the eyelid allow for its quick action and retreat. At a smaller level of analysis, the function of these nerves and muscles likewise relies on the interactions of specific molecules and ions. Even the three-dimensional structure of certain molecules is essential to their function. Your study of anatomy and physiology will make more sense if you continually relate the form of the structures you are studying to their function. In fact, it can be somewhat frustrating to attempt to study anatomy without an understanding of the physiology that a body structure supports. Imagine, for example, trying to appreciate the unique arrangement of the bones of the human hand if you had no conception of the function of the hand. Fortunately, your understanding of how the human hand manipulates tools---from pens to cell phones---helps you appreciate the unique alignment of the thumb in opposition to the four fingers, making your hand a structure that allows you to pinch and grasp objects and type text messages. Before you begin to study the different structures and functions of the human body, it is helpful to consider its basic architecture; that is, how its smallest parts are assembled into larger structures. It is convenient to consider the structures of the body in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, organisms and biosphere.   1.2 Structural Organization of the Human Body -- Anatomy and Physiology ***Levels of Structural Organization of the Human Body *** *The organization of the body often is discussed in terms of six distinct levels of increasing complexity, from the smallest chemical building blocks to a unique human organism.* **THE LEVELS OF ORGANIZATION** To study the chemical level of organization, scientists consider the simplest building blocks of matter: subatomic particles, atoms and molecules. All matter in the universe is composed of one or more unique pure substances called elements, familiar examples of which are hydrogen, oxygen, carbon, nitrogen, calcium, and iron. The smallest unit of any of these pure substances (elements) is an atom. Atoms are made up of subatomic particles such as the proton, electron and neutron. Two or more atoms combine to form a molecule, such as the water molecules, proteins, and sugars found in living things. Molecules are the chemical building blocks of all body structures. A **cell** is the smallest independently functioning unit of a living organism. Even bacteria, which are extremely small, independently-living organisms, have a cellular structure. Each bacterium is a single cell. All living structures of human anatomy contain cells, and almost all functions of human physiology are performed in cells or are initiated by cells. A human cell typically consists of flexible membranes that enclose cytoplasm, a water-based cellular fluid together with a variety of tiny functioning units called **organelles**. In humans, as in all organisms, cells perform all functions of life. A **tissue** is a group of many similar cells (though sometimes composed of a few related types) that work together to perform a specific function. An **organ** is an anatomically distinct structure of the body composed of two or more tissue types. Each organ performs one or more specific physiological functions. An **organ system** is a group of organs that work together to perform major functions or meet physiological needs of the body. **[THE ORGAN SYSTEMS OF THE HUMAN BODY]**      1.2 Structural Organization of the Human Body -- Anatomy and Physiology The organism level is the highest level of organization. An **organism** is a living being that has a cellular structure and that can independently perform all physiologic functions necessary for life. In multicellular organisms, including humans, all cells, tissues, organs, and organ systems of the body work together to maintain the life and health of the organism. The different organ systems each have different functions and therefore unique roles to perform in physiology. These many functions can be summarized in terms of a few that we might consider definitive of human life: organization, metabolism, responsiveness, movement, development, and reproduction. **ORGANIZATION** A human body consists of trillions of cells organized in a way that maintains distinct internal compartments. These compartments keep body cells separated from external environmental threats and keep the cells moist and nourished. They also separate internal body fluids from the countless microorganisms that grow on body surfaces, including the lining of certain passageways that connect to the outer surface of the body. The intestinal tract, for example, is home to more bacterial cells than the total of all human cells in the body, yet these bacteria are outside the body and cannot be allowed to circulate freely inside the body. Cells, for example, have a cell membrane (also referred to as the plasma membrane) that keeps the intracellular environment---the fluids and organelles---separate from the extracellular environment. Blood vessels keep blood inside a closed circulatory system, and nerves and muscles are wrapped in connective tissue sheaths that separate them from surrounding structures. In the chest and abdomen, a variety of internal membranes keep major organs such as the lungs, heart, and kidneys separate from others. The body's largest organ system is the integumentary system, which includes the skin and its associated structures, such as hair and nails. The surface tissue of skin is a barrier that protects internal structures and fluids from potentially harmful microorganisms and other toxins. **METABOLISM** The first law of thermodynamics holds that energy can neither be created nor destroyed---it can only change form. Your basic function as an organism is to consume (ingest) energy and molecules in the foods you eat, convert some of it into fuel for movement, sustain your body functions, and build and maintain your body structures. There are two types of reactions that accomplish this: **anabolism** and **catabolism**. - **Anabolism** is the process whereby smaller, simpler molecules are combined into larger, more complex substances. Your body can assemble, by utilizing energy, the complex chemicals it needs by combining small molecules derived from the foods you eat - **Catabolism** is the process by which larger more complex substances are broken down into smaller simpler molecules. Catabolism releases energy. The complex molecules found in foods are broken down so the body can use their parts to assemble the structures and substances needed for life. Taken together, these two processes are called metabolism. **Metabolism** is the sum of all anabolic and catabolic reactions that take place in the body. Both anabolism and catabolism occur simultaneously and continuously to keep you alive.  Every cell in your body makes use of a chemical compound, **adenosine triphosphate (ATP)**, to store and release energy. The cell stores energy in the synthesis (anabolism) of ATP, then moves the ATP molecules to the location where energy is needed to fuel cellular activities. Then the ATP is broken down (catabolism) and a controlled amount of energy is released, which is used by the cell to perform a particular job. **RESPONSIVENESS** **Responsiveness** is the ability of an organism to adjust to changes in its internal and external environments. An example of responsiveness to external stimuli could include moving toward sources of food and water and away from perceived dangers. Changes in an organism's internal environment, such as increased body temperature, can cause the responses of sweating and the dilation of blood vessels in the skin in order to decrease body temperature, as shown by the runners. **MOVEMENT** Human movement includes not only actions at the joints of the body, but also the motion of individual organs and even individual cells. As you read these words, red and white blood cells are moving throughout your body, muscle cells are contracting and relaxing to maintain your posture and to focus your vision, and glands are secreting chemicals to regulate body functions. Your body is coordinating the action of entire muscle groups to enable you to move air into and out of your lungs, to push blood throughout your body, and to propel the food you have eaten through your digestive tract. Consciously, of course, you contract your skeletal muscles to move the bones of your skeleton to get from one place to another, and to carry out all of the activities of your daily life. 10 things no one tells you before you run an ultra-marathon **DEVELOPMENT, GROETH AND REPRODUCTION** **Development** is all of the changes the body goes through in life. Development includes the process of **differentiation**, in which unspecialized cells become specialized in structure and function to perform certain tasks in the body. Development also includes the processes of growth and repair, both of which involve cell differentiation. **Growth** is the increase in body size. Humans, like all multicellular organisms, grow by increasing the number of existing cells, increasing the amount of non-cellular material around cells (such as mineral deposits in bone), and, within very narrow limits, increasing the size of existing cells. **Reproduction** is the formation of a new organism from parent organisms. In humans, reproduction is carried out by the male and female reproductive systems. Because death will come to all complex organisms, without reproduction, the line of organisms would end. Humans have been adapting to life on Earth for at least the past 200,000 years. Earth and its atmosphere have provided us with air to breathe, water to drink, and food to eat, but these are not the only requirements for survival. Although you may rarely think about it, you also cannot live outside of a certain range of temperature and pressure that the surface of our planet and its atmosphere provides. The next sections explore these four requirements of life. **OXYGEN** Atmospheric air is only about 20 percent oxygen, but that oxygen is a key component of the chemical reactions that keep the body alive, including the reactions that produce ATP. Brain cells are especially sensitive to lack of oxygen because of their requirement for a high-and-steady production of ATP. Brain damage is likely within five minutes without oxygen, and death is likely within ten minutes. **NUTRIENTS** A **nutrient** is a substance in foods and beverages that is essential to human survival. The three basic classes of nutrients are water, the energy-yielding and body-building nutrients, and the micronutrients (vitamins and minerals). The most critical nutrient is water. Depending on the environmental temperature and our state of health, we may be able to survive for only a few days without water. The body's functional chemicals are dissolved and transported in water, and the chemical reactions of life take place in water. Moreover, water is the largest component of cells, blood, and the fluid between cells, and water makes up about 70 percent of an adult's body mass. Water also helps regulate our internal temperature and cushions, protects, and lubricates joints and many other body structures. The energy-yielding nutrients are primarily carbohydrates and lipids, while proteins mainly supply the amino acids that are the building blocks of the body itself. You ingest these in plant and animal foods and beverages, and the digestive system breaks them down into molecules small enough to be absorbed. The breakdown products of carbohydrates and lipids can then be used in the metabolic processes that convert them to ATP. Although you might feel as if you are starving after missing a single meal, you can survive without consuming the energy-yielding nutrients for at least several weeks. Water and the energy-yielding nutrients are also referred to as macronutrients because the body needs them in large amounts. In contrast, micronutrients are vitamins and minerals. These elements and compounds participate in many essential chemical reactions and processes, such as nerve impulses, and some, such as calcium, also contribute to the body's structure. Your body can store some of the micronutrients in its tissues, and draw on those reserves if you fail to consume them in your diet for a few days or weeks. Some others micronutrients, such as vitamin C and most of the B vitamins, are water-soluble and cannot be stored, so you need to consume them every day or two. **NARROW RANGE OF TEMPERATURE** You have probably seen news stories about athletes who died of heat stroke, or hikers who died of exposure to cold. Such deaths occur because the chemical reactions upon which the body depends can only take place within a narrow range of body temperature, from just below to just above 37°C (98.6°F). When body temperature rises well above or drops well below normal, certain proteins (enzymes) that facilitate chemical reactions lose their normal structure and their ability to function and the chemical reactions of metabolism cannot proceed. That said, the body can respond effectively to short-term exposure to heat or cold. One of the body's responses to heat is, of course, sweating. As sweat evaporates from skin, it removes some thermal energy from the body, cooling it. Adequate water (from the extracellular fluid in the body) is necessary to produce sweat, so adequate fluid intake is essential to balance that loss during the sweat response. Not surprisingly, the sweat response is much less effective in a humid environment because the air is already saturated with water. Thus, the sweat on the skin's surface is not able to evaporate, and internal body temperature can get dangerously high. *Humans adapt to some degree to repeated exposure to high temperatures.* The body can also respond effectively to short-term exposure to cold. One response to cold is shivering, which is random muscle movement that generates heat. Another response is increased breakdown of stored energy to generate heat. When that energy reserve is depleted, however, and the core temperature begins to drop significantly, red blood cells will lose their ability to give up oxygen, denying the brain of this critical component of ATP production. This lack of oxygen can cause confusion, lethargy, and eventually loss of consciousness and death. The body responds to cold by reducing blood circulation to the extremities, the hands and feet, in order to prevent blood from cooling there and so that the body's core can stay warm. Even when core body temperature remains stable, however, tissues exposed to severe cold, especially the fingers and toes, can develop frostbite when blood flow to the extremities has been much reduced. This form of tissue damage can be permanent and lead to gangrene, requiring amputation of the affected region. **NARROW RANGE OF ATMOSPHERIC PRESSURE** **Pressure** is a force exerted by a substance that is in contact with another substance. Atmospheric pressure is pressure exerted by the mixture of gases (primarily nitrogen and oxygen) in the Earth's atmosphere. Although you may not perceive it, atmospheric pressure is constantly pressing down on your body. This pressure keeps gases within your body, such as the gaseous nitrogen in body fluids, dissolved. If you were suddenly ejected from a space ship above Earth's atmosphere, you would go from a situation of normal pressure to one of very low pressure. The pressure of the nitrogen gas in your blood would be much higher than the pressure of nitrogen in the space surrounding your body. As a result, the nitrogen gas in your blood would expand, forming bubbles that could block blood vessels and even cause cells to break apart. Atmospheric pressure does more than just keep blood gases dissolved. Your ability to breathe---that is, to take in oxygen and release carbon dioxide---also depends upon a precise atmospheric pressure. Altitude sickness occurs in part because the atmosphere at high altitudes exerts less pressure, reducing the exchange of these gases, and causing shortness of breath, confusion, headache, lethargy, and nausea. Mountain climbers carry oxygen to reduce the effects of both low oxygen levels and low barometric pressure at higher altitudes.  *Climbers on Mount Everest must accommodate extreme cold, low oxygen levels, and low barometric pressure in an environment hostile to human life. *   What Is Homeostasis? - Meaning, Definition And Examples The dynamic pressure of body fluids is also important to human survival. For example, blood pressure, which is the pressure exerted by blood as it flows within blood vessels, must be great enough to enable blood to reach all body tissues, and yet low enough to ensure that the delicate blood vessels can withstand the friction and force of the pulsating flow of pressurized blood. Maintaining homeostasis requires that the body continuously monitor its internal conditions. From body temperature to blood pressure to levels of certain nutrients, each physiological condition has a particular set point. A **set point** is the physiological value around which the normal range fluctuates. A **normal range** is the restricted set of values that is optimally healthful and stable. For example, the set point for normal human body temperature is approximately 37°C (98.6°F) Physiological parameters, such as body temperature and blood pressure, tend to fluctuate within a normal range a few degrees above and below that point. Control centers in the brain and other parts of the body monitor and react to deviations from homeostasis using negative feedback. **Negative feedback** is a mechanism that reverses a deviation from the set point. Therefore, negative feedback maintains body parameters within their normal range. The maintenance of homeostasis by negative feedback goes on throughout the body at all times, and an understanding of negative feedback is thus fundamental to an understanding of human physiology. **NEGATIVE FEEDBACK** A negative feedback system has three basic components. A **sensor**, also referred to a receptor, is a component of a feedback system that monitors a physiological value. This value is reported to the control center. The **control center** is the component in a feedback system that compares the value to the normal range. If the value deviates too much from the set point, then the control center activates an effector. An **effector** is the component in a feedback system that causes a change to reverse the situation and return the value to the normal range. In order to set the system in motion, a stimulus must drive a physiological parameter beyond its normal range (that is, beyond homeostasis). This stimulus is "heard" by a specific sensor. For example, in the control of blood glucose, specific endocrine cells in the pancreas detect excess glucose (the stimulus) in the bloodstream. These pancreatic beta cells respond to the increased level of blood glucose by releasing the hormone insulin into the bloodstream. The insulin signals skeletal muscle fibers, fat cells (adipocytes), and liver cells to take up the excess glucose, removing it from the bloodstream. As glucose concentration in the bloodstream drops, the decrease in concentration---the actual negative feedback---is detected by pancreatic alpha cells, and insulin release stops. This prevents blood sugar levels from continuing to drop below the normal range. Humans have a similar temperature regulation feedback system that works by promoting either heat loss or heat gain. When the brain's temperature regulation center receives data from the sensors indicating that the body's temperature exceeds its normal range, it stimulates a cluster of brain cells referred to as the "heat-loss center." This stimulation has three major effects: - Blood vessels in the skin begin to dilate allowing more blood from the body core to flow to the surface of the skin allowing the heat to radiate into the environment. - As blood flow to the skin increases, sweat glands are activated to increase their output. As the sweat evaporates from the skin surface into the surrounding air, it takes heat with it. - The depth of respiration increases, and a person may breathe through an open mouth instead of through the nasal passageways. This further increases heat loss from the lungs. In contrast, activation of the brain's heat-gain center by exposure to cold reduces blood flow to the skin, and blood returning from the limbs is diverted into a network of deep veins. This arrangement traps heat closer to the body core and restricts heat loss. If heat loss is severe, the brain triggers an increase in random signals to skeletal muscles, causing them to contract and producing shivering. The muscle contractions of shivering release heat while using up ATP. The brain triggers the thyroid gland in the endocrine system to release thyroid hormone, which increases metabolic activity and heat production in cells throughout the body. The brain also signals the adrenal glands to release epinephrine (adrenaline), a hormone that causes the breakdown of glycogen into glucose, which can be used as an energy source. The breakdown of glycogen into glucose also results in increased metabolism and heat production.      5 Minute Bio: Homeostasis! - YouTube **POSITIVE FEEDBACK** **Positive feedback** intensifies a change in the body's physiological condition rather than reversing it. A deviation from the normal range results in more change, and the system moves farther away from the normal range. Positive feedback in the body is normal only when there is a definite end point. Childbirth and the body's response to blood loss are two examples of positive feedback loops that are normal but are activated only when needed. Childbirth at full term is an example of a situation in which the maintenance of the existing body state is not desired. Enormous changes in the mother's body are required to expel the baby at the end of pregnancy. And the events of childbirth, once begun, must progress rapidly to a conclusion or the life of the mother and the baby are at risk. The extreme muscular work of labor and delivery are the result of a positive feedback system.    ***Normal childbirth is driven by a positive feedback loop. A positive feedback loop results in a change in the body's status, rather than a return to homeostasis.*** The first contractions of labor (the stimulus) push the baby toward the cervix (the lowest part of the uterus). The cervix contains stretch-sensitive nerve cells that monitor the degree of stretching (the sensors). These nerve cells send messages to the brain, which in turn causes the pituitary gland at the base of the brain to release the hormone oxytocin into the bloodstream. Oxytocin causes stronger contractions of the smooth muscles in of the uterus (the effectors), pushing the baby further down the birth canal. This causes even greater stretching of the cervix. The cycle of stretching, oxytocin release, and increasingly more forceful contractions stops only when the baby is born. At this point, the stretching of the cervix halts, stopping the release of oxytocin. A second example of positive feedback centers on reversing extreme damage to the body. Following a penetrating wound, the most immediate threat is excessive blood loss. Less blood circulating means reduced blood pressure and reduced perfusion (penetration of blood) to the brain and other vital organs. If perfusion is severely reduced, vital organs will shut down and the person will die. The body responds to this potential catastrophe by releasing substances in the injured blood vessel wall that begin the process of blood clotting. As each step of clotting occurs, it stimulates the release of more clotting substances. This accelerates the processes of clotting and sealing off the damaged area. Clotting is contained in a local area based on the tightly controlled availability of clotting proteins. This is an adaptive, life-saving cascade of events.   Anatomists and health care providers use terminology that can be bewildering to the uninitiated. However, the purpose of this language is not to confuse, but rather to increase precision and reduce medical errors. For example, is a scar "above the wrist" located on the forearm two or three inches away from the hand? Or is it at the base of the hand? Is it on the palm-side or back-side? By using precise anatomical terminology, we eliminate ambiguity. Anatomical terms derive from ancient Greek and Latin words. Because these languages are no longer used in everyday conversation, the meaning of their words does not change. Anatomical terms are made up of roots, prefixes, and suffixes. The root of a term often refers to an organ, tissue, or condition, whereas the prefix or suffix often describes the root. For example, in the disorder hypertension, the prefix "hyper-" means "high" or "over," and the root word "tension" refers to pressure, so the word "hypertension" refers to abnormally high blood pressure. **ANATOMICAL POSITION** To further increase precision, anatomists standardize the way in which they view the body. Just as maps are normally oriented with north at the top, the standard body "map," or **anatomical position**, is that of the body standing upright, with the feet at shoulder width and parallel, toes forward. The upper limbs are held out to each side, and the palms of the hands face forward. Using this standard position reduces confusion. It does not matter how the body being described is oriented, the terms are used as if it is in anatomical position. For example, a scar in the "anterior (front) carpal (wrist) region" would be present on the palm side of the wrist. The term "anterior" would be used even if the hand were palm down on a table.   Anatomical Terminology \| Anatomy and Physiology I ***REGIONS OF THE HUMAN BODY**: The human body is shown in anatomical position in an (a) anterior view and a (b) posterior view. The regions of the body are labeled in boldface.* A body that is lying down is described as either prone or supine. **Prone** describes a face-down orientation, and **supine** describes a face up orientation. These terms are sometimes used in describing the position of the body during specific physical examinations or surgical procedures. **REGIONAL TERMS** The human body's numerous regions have specific terms to help increase precision. Notice that the term "brachium" or "arm" is reserved for the "upper arm" and "antebrachium" or "forearm" is used rather than "lower arm." Similarly, "femur" or "thigh" is correct, and "leg" or "crus" is reserved for the portion of the lower limb between the knee and the ankle. You will be able to describe the body's regions using the terms from the figure. **DIRECTIONAL TERMS** Certain directional anatomical terms appear throughout this and any other anatomy textbook. These terms are essential for describing the relative locations of different body structures. For instance, an anatomist might describe one band of tissue as "inferior to" another or a physician might describe a tumor as "superficial to" a deeper body structure. Commit these terms to memory to avoid confusion when you are studying or describing the locations of particular body parts. - **Anterior** (or **ventral**) Describes the front or direction toward the front of the body. The toes are anterior to the foot. - **Posterior** (or **dorsal**) Describes the back or direction toward the back of the body. The popliteus is posterior to the patella. - **Superior** (or **cranial**) describes a position above or higher than another part of the body proper. The orbits are superior to the oris. - **Inferior** (or **caudal**) describes a position below or lower than another part of the body proper; near or toward the tail (in humans, the coccyx, or lowest part of the spinal column). The pelvis is inferior to the abdomen. - **Lateral** describes the side or direction toward the side of the body. The thumb (pollex) is lateral to the digits. - **Medial** describes the middle or direction toward the middle of the body. The hallux is the medial toe. - **Proximal** describes a position in a limb that is nearer to the point of attachment or the trunk of the body. The brachium is proximal to the antebrachium. - **Distal** describes a position in a limb that is farther from the point of attachment or the trunk of the body. The crus is distal to the femur. - **Superficial** describes a position closer to the surface of the body. The skin is superficial to the bones. - **Deep** describes a position farther from the surface of the body. The brain is deep to the skull.    ***Directional Terms: Applied to the Human Body Paired directional terms are shown as applied to the human body.*** ** ** **BODY PLANES** A **section** is a two-dimensional surface of a three-dimensional structure that has been cut. Modern medical imaging devices enable clinicians to obtain "virtual sections" of living bodies. We call these scans. Body sections and scans can be correctly interpreted, however, only if the viewer understands the plane along which the section was made. A **plane** is an imaginary two-dimensional surface that passes through the body. There are three planes commonly referred to in anatomy and medicine. The **sagittal plane** is the plane that divides the body or an organ vertically into right and left sides. If this vertical plane runs directly down the middle of the body, it is called the midsagittal or median plane. If it divides the body into unequal right and left sides, it is called a parasagittal plane or less commonly a longitudinal section. - The **frontal plane** is the plane that divides the body or an organ into an anterior (front) portion and a posterior (rear) portion. The frontal plane is often referred to as a coronal plane. ("Corona" is Latin for "crown.") - The **transverse plane** is the plane that divides the body or organ horizontally into upper and lower portions. Transverse planes produce images referred to as cross sections.   Anatomical Planes - Coronal - Sagittal - TeachMeAnatomy ***Planes of the Body: The three planes most commonly used in anatomical and medical imaging are the sagittal, frontal (or coronal), and transverse plane.*** ** ** **BODY CAVITIES AND SEROUS MEMBRANES** The body maintains its internal organization by means of membranes, sheaths, and other structures that separate compartments. The **dorsal (posterior) cavity** and the **ventral (anterior) cavity** are the largest body compartments. These cavities contain and protect delicate internal organs, and the ventral cavity allows for significant changes in the size and shape of the organs as they perform their functions. The lungs, heart, stomach, and intestines, for example, can expand and contract without distorting other tissues or disrupting the activity of nearby organs. **Subdivisions of the Posterior (Dorsal) and Anterior (Ventral) Cavities** The posterior (dorsal) and anterior (ventral) cavities are each subdivided into smaller cavities. In the posterior (dorsal) cavity, the **cranial cavity** houses the brain, and the **spinal cavity** (or vertebral cavity) encloses the spinal cord. Just as the brain and spinal cord make up a continuous, uninterrupted structure, the cranial and spinal cavities that house them are also continuous. The brain and spinal cord are protected by the bones of the skull and vertebral column and by cerebrospinal fluid, a colorless fluid produced by the brain, which cushions the brain and spinal cord within the posterior (dorsal) cavity. The anterior (ventral) cavity has two main subdivisions: the thoracic cavity and the abdominopelvic cavity. The **thoracic cavity** is the more superior subdivision of the anterior cavity, and it is enclosed by the rib cage. The thoracic cavity contains the lungs and the heart, which is located in the mediastinum. The diaphragm forms the floor of the thoracic cavity and separates it from the more inferior abdominopelvic cavity. The **abdominopelvic cavity** is the largest cavity in the body. Although no membrane physically divides the abdominopelvic cavity, it can be useful to distinguish between the abdominal cavity, the division that houses the digestive organs, and the pelvic cavity, the division that houses the organs of reproduction.    ***Dorsal and Ventral Body Cavities: **The ventral cavity includes the thoracic and abdominopelvic cavities and their subdivisions. The dorsal cavity includes the cranial and spinal cavities.* ** ** **ABDOMINAL REGIONS AND QUADRANTS** To promote clear communication, for instance about the location of a patient's abdominal pain or a suspicious mass, health care providers typically divide up the cavity into either nine regions or four quadrants. The more detailed regional approach subdivides the cavity with one horizontal line immediately inferior to the ribs and one immediately superior to the pelvis, and two vertical lines drawn as if dropped from the midpoint of each clavicle (collarbone). There are nine resulting regions. The simpler quadrants approach, which is more commonly used in medicine, subdivides the cavity with one horizontal and one vertical line that intersect at the patient's umbilicus (navel).   Quadrants and regions of abdomen - Wikipedia ***Regions and Quadrants of the Peritoneal Cavity: **There are (a) nine abdominal regions and (b) four abdominal quadrants in the peritoneal cavity**.***   **MEMBRANES OF THE ANTERIOR (VENTRAL) BODY CAVITY** A **serous membrane** (also referred to a serosa) is one of the thin membranes that cover the walls and organs in the thoracic and abdominopelvic cavities. The parietal layers of the membranes line the walls of the body cavity (pariet- refers to a cavity wall). The visceral layer of the membrane covers the organs (the viscera). Between the parietal and visceral layers is a very thin, fluid-filled serous space, or cavity. There are three serous cavities and their associated membranes. The pleura is the serous membrane that encloses the pleural cavity; the pleural cavity surrounds the lungs. The pericardium is the serous membrane that encloses the pericardial cavity; the pericardial cavity surrounds the heart. The peritoneum is the serous membrane that encloses the peritoneal cavity; the peritoneal cavity surrounds several organs in the abdominopelvic cavity. The serous membranes form fluid-filled sacs, or cavities, that are meant to cushion and reduce friction on internal organs when they move, such as when the lungs inflate or the heart beats. Both the parietal and visceral serosa secrete the thin, slippery serous fluid located within the serous cavities. The pleural cavity reduces friction between the lungs and the body wall. Likewise, the pericardial cavity reduces friction between the heart and the wall of the pericardium. The peritoneal cavity reduces friction between the abdominal and pelvic organs and the body wall. Therefore, serous membranes provide additional protection to the viscera they enclose by reducing friction that could lead to inflammation of the organs.  **Serous Membrane** Serous membrane lines the pericardial cavity and reflects back to cover the heart---much the same way that an underinflated balloon would form two layers surrounding a fist. **MEDICAL IMAGING** For thousands of years, fear of the dead and legal sanctions limited the ability of anatomists and physicians to study the internal structures of the human body. An inability to control bleeding, infection, and pain made surgeries infrequent, and those that were performed---such as wound suturing, amputations, tooth and tumor removals, skull drilling, and cesarean births---did not greatly advance knowledge about internal anatomy. Theories about the function of the body and about disease were therefore largely based on external observations and imagination. During the fourteenth and fifteenth centuries, however, the detailed anatomical drawings of Italian artist and anatomist Leonardo da Vinci and Flemish anatomist Andreas Vesalius were published, and interest in human anatomy began to increase. Medical schools began to teach anatomy using human dissection; although some resorted to grave robbing to obtain corpses. Laws were eventually passed that enabled students to dissect the corpses of criminals and those who donated their bodies for research. Still, it was not until the late nineteenth century that medical researchers discovered non-surgical methods to look inside the living body. **X-RAYS** German physicist Wilhelm Röntgen (1845--1923) was experimenting with electrical current when he discovered that a mysterious and invisible "ray" would pass through his flesh but leave an outline of his bones on a screen coated with a metal compound. In 1895, Röntgen made the first durable record of the internal parts of a living human: an "X-ray" image (as it came to be called) of his wife's hand. Scientists around the world quickly began their own experiments with X-rays, and by 1900, X-rays were widely used to detect a variety of injuries and diseases. In 1901, Röntgen was awarded the first Nobel Prize for physics for his work in this field. The X-ray is a form of high energy electromagnetic radiation with a short wavelength capable of penetrating solids and ionizing gases. As they are used in medicine, X-rays are emitted from an X-ray machine and directed toward a specially treated metallic plate placed behind the patient's body. The beam of radiation results in darkening of the X-ray plate. X-rays are slightly impeded by soft tissues, which show up as gray on the X-ray plate, whereas hard tissues, such as bone, largely block the rays, producing a light-toned "shadow." Thus, X-rays are best used to visualize hard body structures such as teeth and bones. Like many forms of high energy radiation, however, X-rays are capable of damaging cells and initiating changes that can lead to cancer. This danger of excessive exposure to X-rays was not fully appreciated for many years after their widespread use. Refinements and enhancements of X-ray techniques have continued throughout the twentieth and twenty-first centuries. Although often supplanted by more sophisticated imaging techniques, the X-ray remains a "workhorse" in medical imaging, especially for viewing fractures and for dentistry. The disadvantage of irradiation to the patient and the operator is now attenuated by proper shielding and by limiting exposure. ***X-Ray of a Hand: **High energy electromagnetic radiation allows the internal structures of the body, such as bones, to be seen in X-rays like these. (credit: Trace Meek/flickr)* **MODERN MEDICAL IMAGING** X-rays can depict a two-dimensional image of a body region, and only from a single angle. In contrast, more recent medical imaging technologies produce data that is integrated and analyzed by computers to produce three-dimensional images or images that reveal aspects of body functioning. **Computed Tomography** Tomography refers to imaging by sections. **Computed tomography (CT)** is a noninvasive imaging technique that uses computers to analyze several cross-sectional X-rays in order to reveal minute details about structures in the body ([Figure 1.19Links to an external site.](https://openstax.org/books/anatomy-and-physiology/pages/1-7-medical-imaging#fig-ch01_07_02)**a**). The technique was invented in the 1970s and is based on the principle that, as X-rays pass through the body, they are absorbed or reflected at different levels. In the technique, a patient lies on a motorized platform while a computerized axial tomography (CAT) scanner rotates 360 degrees around the patient, taking X-ray images. A computer combines these images into a two-dimensional view of the scanned area, or "slice."  Since 1970, the development of more powerful computers and more sophisticated software has made CT scanning routine for many types of diagnostic evaluations. It is especially useful for soft tissue scanning, such as of the brain and the thoracic and abdominal viscera. Its level of detail is so precise that it can allow physicians to measure the size of a mass down to a millimeter. The main disadvantage of CT scanning is that it exposes patients to a dose of radiation many times higher than that of X-rays. In fact, children who undergo CT scans are at increased risk of developing cancer, as are adults who have multiple CT scans. **MAGNETIC RESONANCE IMAGING** **Magnetic resonance imaging (MRI)** is a noninvasive medical imaging technique based on a phenomenon of nuclear physics discovered in the 1930s, in which matter exposed to magnetic fields and radio waves was found to emit radio signals. In 1970, a physician and researcher named Raymond Damadian noticed that malignant (cancerous) tissue gave off different signals than normal body tissue. He applied for a patent for the first MRI scanning device, which was in use clinically by the early 1980s. The early MRI scanners were crude, but advances in digital computing and electronics led to their advancement over any other technique for precise imaging, especially to discover tumors. MRI also has the major advantage of not exposing patients to radiation. Drawbacks of MRI scans include their much higher cost, and patient discomfort with the procedure. The MRI scanner subjects the patient to such powerful electromagnets that the scan room must be shielded. The patient must be enclosed in a metal tube-like device for the duration of the scan sometimes as long as thirty minutes, which can be uncomfortable and impractical for ill patients. The device is also so noisy that, even with earplugs, patients can become anxious or even fearful. These problems have been overcome somewhat with the development of "open" MRI scanning, which does not require the patient to be entirely enclosed in the metal tube. Patients with iron-containing metallic implants (internal sutures, some prosthetic devices, and so on) cannot undergo MRI scanning because it can dislodge these implants. Functional MRIs (fMRIs), which detect the concentration of blood flow in certain parts of the body, are increasingly being used to study the activity in parts of the brain during various body activities. This has helped scientists learn more about the locations of different brain functions and more about brain abnormalities and diseases. **POSITRON EMISSION TOMOGRAPHY** **Positron emission tomography (PET)** is a medical imaging technique involving the use of so-called radiopharmaceuticals, substances that emit radiation that is short-lived and therefore relatively safe to administer to the body. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential. The main advantage is that PET can illustrate physiologic activity---including nutrient metabolism and blood flow---of the organ or organs being targeted, whereas CT and MRI scans can only show static images. PET is widely used to diagnose a multitude of conditions, such as heart disease, the spread of cancer, certain forms of infection, brain abnormalities, bone disease, and thyroid disease. **Ultrasonography** **Ultrasonography** is an imaging technique that uses the transmission of high-frequency sound waves into the body to generate an echo signal that is converted by a computer into a real-time image of anatomy and physiology. Ultrasonography is the least invasive of all imaging techniques, and it is therefore used more freely in sensitive situations such as pregnancy. The technology was first developed in the 1940s and 1950s. Ultrasonography is used to study heart function, blood flow in the neck or extremities, certain conditions such as gallbladder disease, and fetal growth and development. The main disadvantages of ultrasonography are that the image quality is heavily operator-dependent and that it is unable to penetrate bone and gas.   **DEFINTION OF TERMS** **abdominopelvic cavity** division of the anterior (ventral) cavity that houses the abdominal and pelvic viscera **anabolism** assembly of more complex molecules from simpler molecules **anatomical position** standard reference position used for describing locations and directions on the human body **anatomy** science that studies the form and composition of the body's structures **anterior** describes the front or direction toward the front of the body; also referred to as ventral **anterior cavity** larger body cavity located anterior to the posterior (dorsal) body cavity; includes the serous membrane-lined pleural cavities for the lungs, pericardial cavity for the heart, and peritoneal cavity for the abdominal and pelvic organs; also referred to as ventral cavity **catabolism** breaking down of more complex molecules into simpler molecules **caudal** describes a position below or lower than another part of the body proper; near or toward the tail (in humans, the coccyx, or lowest part of the spinal column); also referred to as inferior **cell** smallest independently functioning unit of all organisms; in animals, a cell contains cytoplasm, composed of fluid and organelles **computed tomography (CT)** medical imaging technique in which a computer-enhanced cross-sectional X-ray image is obtained **control center** compares values to their normal range; deviations cause the activation of an effector **cranial** describes a position above or higher than another part of the body proper; also referred to as superior **cranial cavity** division of the posterior (dorsal) cavity that houses the brain **deep** describes a position farther from the surface of the body **development** changes an organism goes through during its life **differentiation** process by which unspecialized cells become specialized in structure and function **distal** describes a position farther from the point of attachment or the trunk of the body **dorsal** describes the back or direction toward the back of the body; also referred to as posterior **dorsal cavity** posterior body cavity that houses the brain and spinal cord; also referred to the posterior body cavity **effector** organ that can cause a change in a value **frontal plane** two-dimensional, vertical plane that divides the body or organ into anterior and posterior portions **gross anatomy** study of the larger structures of the body, typically with the unaided eye; also referred to macroscopic anatomy **growth** process of increasing in size **homeostasis** steady state of body systems that living organisms maintain **inferior** describes a position below or lower than another part of the body proper; near or toward the tail (in humans, the coccyx, or lowest part of the spinal column); also referred to as caudal **lateral** describes the side or direction toward the side of the body **magnetic resonance imaging (MRI)** medical imaging technique in which a device generates a magnetic field to obtain detailed sectional images of the internal structures of the body **medial** describes the middle or direction toward the middle of the body **metabolism** sum of all of the body's chemical reactions **microscopic anatomy** study of very small structures of the body using magnification **negative feedback** homeostatic mechanism that tends to stabilize an upset in the body's physiological condition by preventing an excessive response to a stimulus, typically as the stimulus is removed **normal range** range of values around the set point that do not cause a reaction by the control center **nutrient** chemical obtained from foods and beverages that is critical to human survival **organ** functionally distinct structure composed of two or more types of tissues **organ system** group of organs that work together to carry out a particular function **organism** living being that has a cellular structure and that can independently perform all physiologic functions necessary for life **pericardium** sac that encloses the heart **peritoneum** serous membrane that lines the abdominopelvic cavity and covers the organs found there **physiology** science that studies the chemistry, biochemistry, and physics of the body's functions **plane** imaginary two-dimensional surface that passes through the body **pleura** serous membrane that lines the pleural cavity and covers the lungs **positive feedback** mechanism that intensifies a change in the body's physiological condition in response to a stimulus **positron emission tomography (PET)** medical imaging technique in which radiopharmaceuticals are traced to reveal metabolic and physiological functions in tissues **posterior** describes the back or direction toward the back of the body; also referred to as dorsal **posterior cavity** posterior body cavity that houses the brain and spinal cord; also referred to as dorsal cavity **pressure** force exerted by a substance in contact with another substance **prone** face down **proximal** describes a position nearer to the point of attachment or the trunk of the body **regional anatomy** study of the structures that contribute to specific body regions **renewal** process by which worn-out cells are replaced **reproduction** process by which new organisms are generated **responsiveness** ability of an organisms or a system to adjust to changes in conditions **sagittal plane** two-dimensional, vertical plane that divides the body or organ into right and left sides **section** in anatomy, a single flat surface of a three-dimensional structure that has been cut through **sensor** (also, receptor) reports a monitored physiological value to the control center **serosa** membrane that covers organs and reduces friction; also referred to as serous membrane **serous membrane** membrane that covers organs and reduces friction; also referred to as serosa **set point** ideal value for a physiological parameter; the level or small range within which a physiological parameter such as blood pressure is stable and optimally healthful, that is, within its parameters of homeostasis **spinal cavity** division of the dorsal cavity that houses the spinal cord; also referred to as vertebral cavity **superficial** describes a position nearer to the surface of the body **superior** describes a position above or higher than another part of the body proper; also referred to as cranial **supine** face up **systemic anatomy** study of the structures that contribute to specific body systems **thoracic cavity** division of the anterior (ventral) cavity that houses the heart, lungs, esophagus, and trachea **tissue** group of similar or closely related cells that act together to perform a specific function **transverse plane** two-dimensional, horizontal plane that divides the body or organ into superior and inferior portions **ultrasonography** application of ultrasonic waves to visualize subcutaneous body structures such as tendons and organs **ventral** describes the front or direction toward the front of the body; also referred to as anterior **ventral cavity** larger body cavity located anterior to the posterior (dorsal) body cavity; includes the serous membrane-lined pleural cavities for the lungs, pericardial cavity for the heart, and peritoneal cavity for the abdominal and pelvic organs; also referred to as anterior body cavity **X-ray** form of high energy electromagnetic radiation with a short wavelength capable of penetrating solids and ionizing gases; used in medicine as a diagnostic aid to visualize body structures such as bones   ***\~Introduction to the Human Body\~***