Samenvattingen paragrafen e-module week 4 PDF

[Samenvattingen paragrafen E-module week 4] [Week 4 3](#week-4) [Deel 1 3](#deel-1) [Deel 2 10](#deel-2) [Deel 3 14](#deel-3) [Deel 4 17](#deel-4) Week 4 ====== Deel 1 ------ +-----------+-----------+-----------+-----------+-----------+-----------+ | Page | Chapter | Section | Parag...

[Samenvattingen paragrafen E-module week 4] [Week 4 3](#week-4) [Deel 1 3](#deel-1) [Deel 2 10](#deel-2) [Deel 3 14](#deel-3) [Deel 4 17](#deel-4) Week 4 ====== Deel 1 ------ +-----------+-----------+-----------+-----------+-----------+-----------+ | Page | Chapter | Section | Paragraph | Hoeveel | Samenvatt | | | | | | aandacht? | ing | +===========+===========+===========+===========+===========+===========+ | **397** | Chapter | | | | | | | 7: | | | | | | | Control | | | | | | | of Gene | | | | | | | Expressio | | | | | | | n | | | | | +-----------+-----------+-----------+-----------+-----------+-----------+ | **445** | | POST-TRAN | | | | | | | SCRIPTION | | | | | | | AL | | | | | | | CONTROLS | | | | +-----------+-----------+-----------+-----------+-----------+-----------+ | **445** | | | Introduct | \*\*\*\* | Post-tran | | | | | ion | | scription | | | | | | | ele | | | | | | | controles | | | | | | | vinden | | | | | | | plaats | | | | | | | nadat de | | | | | | | transcrip | | 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erase | | | | | | | II | | | | | | | hindert. | +-----------+-----------+-----------+-----------+-----------+-----------+ | **446** | | | Riboswitc | \*\* | *Riboswit | | | | | hes | | ches* | | | | | Probably | | zijn | | | | | Represent | | korte | | | | | Ancient | | RNA-seque | | | | | Farms of | | nties | | | | | Gene | | die van | | | | | Control | | vorm | | | | | | | verandere | | | | | | | n | | | | | | | als ze | | | | | | | kleine | | | | | | | moleculen | | | | | | | (bijvoorb | | | | | | | eeld | | | | | | | metabolie | | | | | | | ten) | | | | | | | binden. | | | | | | | Zo | | | | | | | blokkeren | | | | | | | of staan | | | | | | | ze juist | | | | | | | toe dat | | | | | | | RNA-polym | | | | | | | erase | | | | | | | zijn werk | | | | | | | doet en | | | | | | | op deze | | | | | | | manier | | | | | | | reguleren | | | | | | | ze dus | | | | | | | genexpres | | | | | | | sie. | | | | | | | Elke | | | | | | | riboswitc | | | | | | | h | | | | | | | herkent | | | | | | 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de | | | | | | | definitie | | | | | | | ve | | | | | | | mRNA | | | | | | | sequentie | | | | | | |. | +-----------+-----------+-----------+-----------+-----------+-----------+ | **448** | | | The | \* | Dat een | | | | | Definitio | | gen door | | | | | n | | alternati | | | | | of a Gene | | eve | | | | | Has Been | | splicing | | | | | Modified | | voor | | | | | Since the | | verschill | | | | | Discovery | | ende | | | | | of | | eiwitten | | | | | Alternati | | kan | | | | | ve | | coderen, | | | | | RNA | | stelt de | | | | | Splicing | | oude | | | | | | | definitie | | | | | | | van een | | | | | | | gen ter | | | | | | | discussie | | | | | | |. | | | | | | | De | | | | | | | auteurs | | | | | | | stellen | | | | | | | voor een | | | | | | | eiwit-cod | | | | | | | erend | | | | | | | gen te | | | | | | | definiëre | | | | | | | n | | | | | | | als een | | | | | | | DNA-seque | | | | | | | ntie | | | | | | | die wordt | | | | | | | afgeschre | | | | | | | ven | | | | | | | als één | | | | | | | eenheid | | | | | | | en | | | | | | | codeert | | | | | | | voor een | | | | | | | set | | | | | | | nauwverwa | | | | | | | nte | | | | | | | polypepti | | | | | | | de-ketens | | | | | | |. | +-----------+-----------+-----------+-----------+-----------+-----------+ | **449** | | | Back | \*\* | Heel soms | | | | | Splicing | | ontstaan | | | | | Can | | er | | | | | Produce | | circulair | | | | | Circular | | e | | | | | RNA | | stukken | | | | | Molecules | | RNA | | | | | | | doordat | | | | | | | er | | | | | | | backsplic | | | | | | | ing | | | | | | | plaatsvin | | | | | | | dt. | | | | | | | Er wordt | | | | | | | dan een | | | | | | | 3'splice- | | | | | | | site | | | | | | | verbonden | | | | | | | met een | | | | | | | verderop | | | | | | | gelegen | | | | | | | 5'splice- | | | | | | | site | | | | | | | (die | | | | | | | blijkbaar | | | | | | | ook al | | | | | | | uit het | | | | | | | RNA-polym | | | | | | | erase | | | | | | | gekomen | | | | 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ylering-p | | | | | | | lekken | | | | | | | in een | | | | | | | intron, | | | | | | | wat leidt | | | | | | | tot een | | | | | | | alternati | | | | | | | ef | | | | | | | splicings | | | | | | | patroon, | | | | | | | waardoor | | | | | | | de | | | | | | | sequentie | | | | | | | van | | | | | | | aminozure | | | | | | | n | | | | | | | aan de | | | | | | | C-terminu | | | | | | | s | | | | | | | wel | | | | | | | degelijk | | | | | | | veranderd | | | | | | | wordt. | | | | | | | Dit kan | | | | | | | bijvoorbe | | | | | | | eld | | | | | | | van | | | | | | | invloed | | | | | | | zijn op | | | | | | | de | | | | | | | lokalisat | | | | | | | ie | | | | | | | van het | | | | | | | eiwit, | | | | | | | zoals bij | | | | | | | B-cellen | | | | | | | waar | | | | | | | alternati | | | | | | | eve | | | | | | | klieving | | | | | | | en | | | | | | | poly-aden | | | | | | | ylering | | | | | | | zorgt | | | | | | | voor het | | | | | | | wel of | | | | | | | niet | | | | | | | hebben | | | | | | | van een | | | | | | | membraana | | | | | | | nker | | | | | | | aan de | | | | | | | antistoff | | | | | | | en | | | | | | | (zie ook | | | | | | | figuur | | | | | | | 7-62). | +-----------+-----------+-----------+-----------+-----------+-----------+ | **450** | | | Nucleotid | \* | RNA-nucle | | | | | es | | otiden | | | | | in mRNA | | kunnen | | | | | Can Be | | door | | | | | Covalentl | | enzymen | | | | | y | | op | | | | | Modified | | allerlei | | | | | | | manieren | | | | | | | covalent | | | | | | | gemodific | | | | | | | eerd | | | | | | | worden. | | | | | | | Het is | | | | | | | grotendee | | | | | | | ls | | | | | | | onduideli | | | | | | | jk | | | | | | | wat de | | | | | | | biologisc | | | | | | | he | | | | | | | rol | | | | | | | hiervan | | | | | | | is. | | | | | | | Mogelijk | | | | | | | reguleert | | | | | | | het de | | | | | | | stabilite | | | | | | | it | | | | | | | van RNA | | | | | | | of | | | | | | | afbraak | | | | | | | van het | | | | | | | RNA. | +-----------+-----------+-----------+-----------+-----------+-----------+ | **451** | | | RNA | \*\*\* | Het | | | | | Editing | | proces | | | | | Can | | waarbij | | | | | Change | | de | | | | | the | | sequentie | | | | | Meaning | | van een | | | | | of the | | RNA-trans | | | | | RNA | | cript | | | | | Message | | na | | | | | | | transcrip | | | | | | | tie | | | | | | | veranderd | | | | | | | wordt, | | | | | | | heet | | | | | | | RNA-editi | | | | | | | ng. | | | | | | | In dieren | | | | | | | bestaan | | | | | | | er twee | | | | | | | vormen | | | | | | | van | | | | | | | RNA-editi | | | | | | | ng: | | | | | | | A-to-I | | | | | | | editing | | | | | | | (deaminer | | | | | | | ing | | | | | | | van een | | | | | | | adenine, | | | | | | | leidt tot | | | | | | | vorming | | | | | | | van een | | | | | | | inosine) | | | | | | | en C-to-U | | | | | | | editing | | | | | | | (deaminer | | | | | | | ing | | | | | | | van een | | | | | | | cytosine | | | | | | | leidt tot | | | | | | | vorming | | | | | | | van een | | | | | | | uracil). | | | | | | | Deze | | | | | | | editing | | | | | | | zorgt | | | | | | | ervoor | | | | | | | dat de | | | | | | | mRNA-code | | | | | | | verandert | | | | | | | na | | | | | | | transcrip | | | | | | | tie. | | | | | | | Als de | | | | | | | editing | | | | | | | heeft | | | | | | | plaatsgev | | | | | | | onden | | | | | | | op het | | | | | | | coderende | | | | | | | gedeelte | | | | | | | van het | | | | | | | mRNA, kan | | | | | | | de | | | | | | | aminozuur | | | | | | | volgorde | | | | | | | van het | | | | | | | eiwit | | | | | | | veranderd | | | | | | | worden of | | | | | | | een | | | | | | | prematuur | | | | | | | stopcodon | | | | | | | gecreëerd | | | | | | | worden | | | | | | | (waardoor | | | | | | | een | | | | | | | verkort | | | | | | | eiwit | | | | | | | ontstaat) | | | | | | |. | | | | | | | Editing | | | | | | | buiten de | | | | | | | coding | | | | | | | region | | | | | | | kan | | | | | | | zorgen | | | | | | | voor | | | | | | | alternati | | | | | | | eve | | | | | | | splicing | | | | | | | en | | | | | | | beïnvloed | | | | | | | ing | | | | | | | van mRNA | | | | | | | transport | | | | | | | van de | | | | | | | kern naar | | | | | | | het | | | | | | | cytosol, | | | | | | | van | | | | | | | translati | | | | | | | e-efficië | | | | | | | ntie | | | | | | | en van | | | | | | | basenpari | | | | | | | ng | | | | | | | van miRNA | | | | | | | met het | | | | | | | mRNA. | +-----------+-----------+-----------+-----------+-----------+-----------+ | **452** | | | The Human | \*\*\* | Naar | | | | | AIDS | | schatting | | | | | Virus | | verlaat | | | | | lllustrat | | slechts | | | | | es | | 1/20 van | | | | | How RNA | | het | | | | | Transport | | gesynthet | | | | | from the | | iseerde | | | | | Nucleus | | RNA de | | | | | Can Be | | nucleus. | | | | | Regulated | | In | | | | | | | principe | | | | | | | wordt | | | | | | | alleen | | | | | | | RNA dat | | | | | | | volledig | | | | | | | geprocess | | | | | | | ed | | | | | | | is uit de | | | | | | | nucleus | | | | | | | geëxporte | | | | | | | erd. | | | | | | | Er zijn | | | | | | | echter | | | | | | | mechanism | | | | | | | en | | | | | | | die dit | | | | | | | kwaliteit | | | | | | | scontrole | | | | | | | systeem | | | | | | | kunnen | | | | | | | omzeilen. | | | | | | | Deze | | | | | | | mechanism | | | | | | | en | | | | | | | behoren | | | | | | | tot het | | | | | | | post-tran | | | | | | | scription | | | | | | | ele | | | | | | | regulatie | | | | | | | proces | | | | | | | 'geregule | | | | | | | erd | | | | | | | nucleair | | | | | | | transport | | | | | | | '. | | | | | | | Het | | | | | | | transport | | | | | | | eren | | | | | | | van | | | | | | | ongesplic | | | | | | | ede | | | | | | | RNA's uit | | | | | | | de kern | | | | | | | naar het | | | | | | | cytosol | | | | | | | is een | | | | | | | voorbeeld | | | | | | | van zo'n | | | | | | | mechanism | | | | | | | e. | +-----------+-----------+-----------+-----------+-----------+-----------+ | **453** | | | mRNAs Can | \*\*\* | Sommige | | | | | Be | | mRNA's | | | | | Localized | | worden | | | | | to | | naar een | | | | | Specific | | specifiek | | | | | Regions | | e | | | | | of the | | locatie | | | | | Cytosol | | in de cel | | | | | | | gebracht | | | | | | | voordat | | | | | | | echte | | | | | | | translati | | | | | | | e | | | | | | | start, | | | | | | | zodat ze | | | | | | | vlakbij | | | | | | | de plek | | | | | | | waar het | | | | | | | gecodeerd | | | | | | | e | | | | | | | eiwit | | | | | | | nodig is, | | | | | | | getransle | | | | | | | erd | | | | | | | worden. | | | | | | | Het | | | | | | | signaal | | | | | | | voor deze | | | | | | | lokalisat | | | | | | | ie | | | | | | | zit | | | | | | | meestal | | | | | | | in de | | | | | | | 3'UTR. | | | | | | | Verschill | | | | | | | ende | | | | | | | mechanism | | | | | | | en | | | | | | | voor deze | | | | | | | RNA | | | | | | | lokalisat | | | | | | | ie | | | | | | | zijn | | | | | | | (Figuur | | | | | | | 7-68): | | | | | | | | | | | | | | -*Directe | | | | | | | d | | | | | | | transport | | | | | | | *: | | | | | | | mRNA-mole | | | | | | | culen | | | | | | | binden | | | | | | | aan | | | | | | | motoreiwi | | | | | | | tten | | | | | | | die de | | | | | | | mRNA-mole | | | | | | | culen | | | | | | | over het | | | | | | | cytoskele | | | | | | | t | | | | | | | naar een | | | | | | | specifiek | | | | | | | e | | | | | | | plek | | | | | | | transport | | | | | | | eren, | | | | | | | waar ze | | | | | | | vervolgen | | | | | | | s | | | | | | | vastgehou | | | | | | | den | | | | | | | worden | | | | | | | door | | | | | | | 'anker-ei | | | | | | | witten'. | | | | | | | | | | | | | | -*Random | | | | | | | diffusion | | | | | | | and | | | | | | | trapping* | | | | | | | : | | | | | | | op een | | | | | | | specifiek | | | | | | | e | | | | | | | plek in | | | | | | | de cel | | | | | | | bevinden | | | | | | | zich | | | | | | | 'ankereiw | | | | | | | itten' | | | | | | | die | | | | | | | specifiek | | | | | | | e | | | | | | | mRNA-mole | | | | | | | culen | | | | | | | vasthoude | | | | | | | n. | | | | | | | | | | | | | | -*Local | | | | | | | protectio | | | | | | | n | | | | | | | by | | | | | | | trapping* | | | | | | | : | | | | | | | de mRNA's | | | | | | | worden | | | | | | | overal in | | | | | | | de cel | | | | | | | snel | | | | | | | afgebroke | | | | | | | n, | | | | | | | behalve | | | | | | | op de | | | | | | | plek waar | | | | | | | zich | | | | | | | ankereiwi | | | | | | | tten | | | | | | | bevinden. | | | | | | | Deze | | | | | | | eiwitten | | | | | | | binden de | | | | | | | mRNA's, | | | | | | | waardoor | | | | | | | ze | | | | | | | beschermd | | | | | | | zijn | | | | | | | tegen | | | | | | | afbraak. | +-----------+-----------+-----------+-----------+-----------+-----------+ | **456** | | | Untransla | \*\* | In | | | | | ted | | prokaryot | | | | | Regions | | en | | | | | of mRNAs | | kan de | | | | | Control | | kleine | | | | | Their | | ribosomal | | | | | Translati | | e | | | | | on | | subunit | | | | | | | direct | | | | | | | landen en | | | | | | | binden op | | | | | | | de | | | | | | | zogenaamd | | | | | | | e | | | | | | | Shine-Dal | | | | | | | garno | | | | | | | sequentie | | | | | | | , | | | | | | | gelegen | | | | | | | een paar | | | | | | | nucleotid | | | | | | | en | | | | | | | upstream | | | | | | | van het | | | | | | | AUG-start | | | | | | | codon. | | | | | | | In | | | | | | | eukaryote | | | | | | | n | | | | | | | begint de | | | | | | | kleine | | | | | | | ribosomal | | | | | | | e | | | | | | | subunit | | | | | | | te | | | | | | | scannen | | | | | | | vanaf de | | | | | | | 5'-Cap, | | | | | | | op zoek | | | | | | | naar een | | | | | | | AUG-start | | | | | | | codon, | | | | | | | waarbij | | | | | | | de | | | | | | | omliggend | | | | | | | e | | | | | | | nucleotid | | | | | | | en | | | | | | | ook van | | | | | | | belang | | | | | | | zijn voor | | | | | | | de | | | | | | | herkennin | | | | | | | g | | | | | | | van een | | | | | | | AUG als | | | | | | | startcodo | | | | | | | n | | | | | | | (er is | | | | | | | hier dus | | | | | | | ook | | | | | | | sprake | | | | | | | van een | | | | | | | consensus | | | | | | | sequentie | | | | | | | !). | | | | | | | De | | | | | | | sterkte | | | | | | | van deze | | | | | | | sequentie | | | | | | | s | | | | | | | (in welke | | | | | | | mate ze | | | | | | | overeenko | | | | | | | men | | | | | | | met de | | | | | | | consensus | | | | | | | sequentie | | | | | | | ) | | | | | | | is van | | | | | | | grote | | | | | | | invloed | | | | | | | op de | | | | | | | frequenti | | | | | | | e | | | | | | | van | | | | | | | translati | | | | | | | e-initiat | | | | | | | ie. | | | | | | | | | | | | | | Omdat in | | | | | | | eukaryote | | | | | | | n | | | | | | | de kleine | | | | | | | ribosomal | | | | | | | e | | | | | | | subunit | | | | | | | gaat | | | | | | | scannen | | | | | | | vanaf de | | | | | | | 5'-Cap is | | | | | | | ook de | | | | | | | lengte | | | | | | | van de | | | | | | | 5'-UTR | | | | | | | bepalend | | | | | | | voor de | | | | | | | frequenti | | | | | | | e | | | | | | | van | | | | | | | translati | | | | | | | e-initiat | | | | | | | ie. | | | | | | | Hoe | | | | | | | langer de | | | | | | | 5'-UTR, | | | | | | | hoe | | | | | | | groter de | | | | | | | kans dat | | | | | | | de kleine | | | | | | | ribosomal | | | | | | | e | | | | | | | subunit | | | | | | | van het | | | | | | | mRNA | | | | | | | afvalt, | | | | | | | nog | | | | | | | voordat | | | | | | | een AUG | | | | | | | bereikt | | | | | | | wordt. | | | | | | | | | | | | | | In Figuur | | | | | | | 7-70 | | | | | | | worden | | | | | | | verschill | | | | | | | ende | | | | | | | mechanism | | | | | | | en | | | | | | | van | | | | | | | controle | | | | | | | van | | | | | | | translati | | | | | | | e | | | | | | | gegeven | | | | | | | (voorbeel | | | | | | | den | | | | | | | komen uit | | | | | | | bacteriën | | | | | | | ): | | | | | | | | | | | | | | A) | | | | | | | Eiwitten | | | | | | | binden | | | | | | | aan | | | | | | | sequentie | | | | | | | s | | | | | | | in het | | | | | | | mRNA om | | | | | | | translati | | | | | | | e | | | | | | | te | | | | | | | onderdruk | | | | | | | ken | | | | | | | door | | | | | | | bijvoorbe | | | | | | | eld | | | | | | | de | | | | | | | Shine-Dal | | | | | | | garno | | | | | | | sequentie | | | | | | | te | | | | | | | bedekken. | | | | | | | | | | | | | | B) | | | | | | | Temperatu | | | | | | | ur | | | | | | | heeft | | | | | | | invloed | | | | | | | op | | | | | | | interne | | | | | | | baseparin | | | | | | | g | | | | | | | in het | | | | | | | mRNA en | | | | | | | daarmee | | | | | | | op de | | | | | | | bereikbaa | | | | | | | rheid | | | | | | | van een | | | | | | | AUG. | | | | | | | | | | | | | | C) | | | | | | | Binding | | | | | | | van een | | | | | | | klein | | | | | | | molecuul | | | | | | | aan een | | | | | | | riboswitc | | | | | | | h. | | | | | | | | | | | | | | D) | | | | | | | Basenpari | | | | | | | ng | | | | | | | van | | | | | | | 'antisens | | | | | | | e' | | | | | | | RNA aan | | | | | | | het mRNA | | | | | | | blokkeert | | | | | | | translati | | | | | | | e. | | | | | | | | | | | | | | Bij | | | | | | | eukaryote | | | | | | | n | | | | | | | kan | | | | | | | translati | | | | | | | e | | | | | | | ook | | | | | | | geremd | | | | | | | worden | | | | | | | door | | | | | | | binding | | | | | | | van een | | | | | | | repressor | | | | | | | aan de | | | | | | | 3'-UTR | | | | | | | van een | | | | | | | mRNA, | | | | | | | omdat dan | | | | | | | de 5'-Cap | | | | | | | niet meer | | | | | | | goed in | | | | | | | contact | | | | | | | kan komen | | | | | | | met de | | | | | | | 3'-poly-A | | | | | | | -staart. | +-----------+-----------+-----------+-----------+-----------+-----------+ | **457** | | | The | \*\*\*\* | Een cel | | | | | Phosphory | | kan ook | | | | | lation | | de | | | | | of an | | \'overall | | | | | lnitiatio | | rate\' | | | | | n | | (het | | | | | Factor | | totaal ) | | | | | Regulates | | aan | | | | | Protein | | eiwitsynt | | | | | Synthesis | | hese | | | | | Globally | | reguleren | | | | | | |. | | | | | | | De | | | | | | | fosforyle | | | | | | | ring | | | | | | | van | | | | | | | translati | | | | | | | e-initiat | | | | | | | iefactor | | | | | | | eIF2 | | | | | | | speelt | | | | | | | hier een | | | | | | | grote | | | | | | | rol. | | | | | | | Specifiek | | | | | | | e | | | | | | | kinases | | | | | | | die | | | | | | | reageren | | | | | | | op | | | | | | | veranderi | | | | | | | ngen | | | | | | | van | | | | | | | condities | | | | | | | in de cel | | | | | | | zijn | | | | | | | verantwoo | | | | | | | rdelijk | | | | | | | voor deze | | | | | | | fosforyle | | | | | | | ring.\ | | | | | | | Normaal | | | | | | | gesproken | | | | | | | zorgt | | | | | | | GTP-gebon | | | | | | | den-eIF2 | | | | | | | dat het | | | | | | | met-tRNA | | | | | | | (het | | | | | | | initiator | | | | | | | tRNA) aan | | | | | | | de kleine | | | | | | | ribosomal | | | | | | | e | | | | | | | subunit | | | | | | | bindt. | | | | | | | Daarna | | | | | | | bindt de | | | | | | | kleine | | | | | | | ribosomal | | | | | | | e | | | | | | | subunit | | | | | | | aan de | | | | | | | 5'-kant | | | | | | | van het | | | | | | | mRNA en | | | | | | | scant het | | | | | | | naar een | | | | | | | AUG | | | | | | | startcodo | | | | | | | n. | | | | | | | Wanneer | | | | | | | deze | | | | | | | gevonden | | | | | | | is, | | | | | | | hydrolyse | | | | | | | ert | | | | | | | eIF2 zijn | | | | | | | gebonden | | | | | | | GTP naar | | | | | | | GDP. | | | | | | | Hierdoor | | | | | | | ondergaat | | | | | | | eIF2 een | | | | | | | conformat | | | | | | | ieverande | | | | | | | ring, | | | | | | | waardoor | | | | | | | GDP-eIF2 | | | | | | | dissociee | | | | | | | rt | | | | | | | van de | | | | | | | met-tRNA | | | | | | | en de | | | | | | | kleine | | | | | | | subunit. | | | | | | | Daardoor | | | | | | | kan de | | | | | | | grote | | | | | | | ribosomal | | | | | | | e | | | | | | | subunit | | | | | | | assembler | | | | | | | en | | | | | | | met de | | | | | | | kleine | | | | | | | subunit, | | | | | | | waarna | | | | | | | translati | | | | | | | e | | | | | | | kan | | | | | | | beginnen. | | | | | | | \ | | | | | | | eIF2 kan | | | | | | | alleen | | | | | | | opnieuw | | | | | | | gebruikt | | | | | | | worden | | | | | | | voor | | | | | | | translati | | | | | | | e-initiat | | | | | | | ie | | | | | | | wanneer | | | | | | | GDP | | | | | | | uitgewiss | | | | | | | eld | | | | | | | wordt | | | | | | | voor GTP | | | | | | | door de | | | | | | | guanine | | | | | | | exchange | | | | | | | factor | | | | | | | (GEF) | | | | | | | eIF2B. De | | | | | | | globale | | | | | | | regulatie | | | | | | | van | | | | | | | eiwitsynt | | | | | | | hese | | | | | | | door | | | | | | | fosforyle | | | | | | | ring | | | | | | | van eIF2 | | | | | | | werkt als | | | | | | | volgt: | | | | | | | wanneer | | | | | | | eIF2 | | | | | | | gefosfory | | | | | | | leerd | | | | | | | is, bindt | | | | | | | het met | | | | | | | een hele | | | | | | | hoge | | | | | | | affinitei | | | | | | | t | | | | | | | aan | | | | | | | eIF2B, | | | | | | | waardoor | | | | | | | eIF2B | | | | | | | inactief | | | | | | | wordt. | | | | | |