Antidepressants II

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38 Questions

Which adverse effect may be associated with MAOIs and can lead to potentially fatal outcomes characterized by occipital headache, palpitations, neck stiffness, nausea, vomiting, and chest pain?

Hypertensive crisis

Which gastrointestinal effect can be seen with the use of MAOIs?

Anorexia

What is a potential drug interaction effect of combining MAOIs with other antidepressants like TCAs and SSRIs?

Serotonin syndrome

What potential side effect can occur if MAOIs are combined with sympathomimetic drugs like methyldopa?

Additive hypoglycemic effects

Which symptom is NOT associated with the potentially fatal hypertensive crisis caused by MAOIs?

Dry mouth

Which of the following is a central nervous system side effect that can occur with the use of MAOIs?

Tremors

What is an important consideration for starting MAOI therapy after stopping an SSRI in terms of timing?

Wait for at least 6 weeks

Which side effects are commonly associated with tricyclic antidepressants (TCAs) but not with selective serotonin reuptake inhibitors (SSRIs)?

Dry mouth and sedation

Why have SSRIs largely replaced TCAs and monoamine oxidase inhibitors (MAOIs) in treating depression?

Because SSRIs are relatively safe even in overdose

What is the primary therapeutic action of SSRIs in the treatment of depression?

Blocking the reuptake of serotonin

What is the minimum time typically required for the full therapeutic effect of SSRIs to be realized?

4 weeks

Which of the following is NOT an indication for the use of SSRIs?

Insomnia

Why is it important to consider individual patient responses when choosing an SSRI?

To ensure optimal therapeutic effects

Which of the following is a common misconception regarding SSRIs?

Patients will respond the same to any SSRI prescribed

'University of Baghdad/College of Medicine 2022-2023' provides information about:

A list of SSRIs commonly used

Which neurotransmitters are primarily affected by bupropion?

Dopamine and norepinephrine

What is a significant side effect associated with the use of bupropion?

Increased risk for seizures

How does mirtazapine primarily affect neurotransmission?

By serving as an antagonist at presynaptic α2 receptors

What distinguishes mirtazapine from other antidepressants in terms of side effects?

Is sedating due to its antihistaminic activity

Which atypical antidepressant is specifically mentioned for its usefulness in patients trying to quit smoking?

Bupropion

What group of agents do atypical antidepressants belong to?

Mixed group with actions at different sites

Why should the use of bupropion be avoided in some patients?

Risk for seizures

What differentiates bupropion from SSRIs in terms of side effects?

Has a low incidence of sexual dysfunction

Which antidepressant is known for its sedating effect and is commonly used for insomnia?

Trazodone

What is the main reason behind the sedating effect of Nefazodone and Trazodone?

Histamine H1 blocking activity

Which statement about the absorption of SSRIs after oral administration is correct?

Sertraline absorption is increased by food intake.

Which antidepressant has been associated with a risk for hepatotoxicity?

Nefazodone

What is the main route of excretion for SSRIs?

Urine

Why is Vilazodone unique compared to SSRIs?

5-HT1a partial agonism

What is the suggested mechanism of action for Vortioxetine in treating depression?

5-HT1a agonism and 5-HT3/5-HT7 antagonism

Which SSRIs are potent inhibitors of CYP2D6 isoenzyme?

Fluoxetine and paroxetine

Which antidepressant is specifically mentioned to have a risk for priapism?

Trazodone

What is a contraindication for the use of SSRIs?

Allergy to any of the SSRIs

What contributes to orthostasis and dizziness with Nefazodone and Trazodone use?

Mild to moderate α1 receptor antagonism

Why should caution be used with severely depressed or suicidal patients when prescribing SSRIs?

Risk of increased suicidality

What should be considered when prescribing SSRIs to pregnant women?

Benefits to the mother should outweigh potential risks to the fetus

What is a common adverse effect profile shared by Vilazodone with SSRIs?

'Discontinuation syndrome' risk if abruptly stopped

What effect can SSRIs in breast milk have on babies?

Negative adverse effects on babies

Test your knowledge on pharmacokinetics with a focus on selective serotonin reuptake inhibitors (SSRIs). Learn about the absorption, peak levels, metabolism, and excretion of SSRIs, as well as their interactions with CYP450 enzymes.

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