Antidepressants II
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Antidepressants II

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Questions and Answers

Which adverse effect may be associated with MAOIs and can lead to potentially fatal outcomes characterized by occipital headache, palpitations, neck stiffness, nausea, vomiting, and chest pain?

Hypertensive crisis

Which gastrointestinal effect can be seen with the use of MAOIs?

Anorexia

What is a potential drug interaction effect of combining MAOIs with other antidepressants like TCAs and SSRIs?

Serotonin syndrome

What potential side effect can occur if MAOIs are combined with sympathomimetic drugs like methyldopa?

<p>Additive hypoglycemic effects</p> Signup and view all the answers

Which symptom is NOT associated with the potentially fatal hypertensive crisis caused by MAOIs?

<p>Dry mouth</p> Signup and view all the answers

Which of the following is a central nervous system side effect that can occur with the use of MAOIs?

<p>Tremors</p> Signup and view all the answers

What is an important consideration for starting MAOI therapy after stopping an SSRI in terms of timing?

<p>Wait for at least 6 weeks</p> Signup and view all the answers

Which side effects are commonly associated with tricyclic antidepressants (TCAs) but not with selective serotonin reuptake inhibitors (SSRIs)?

<p>Dry mouth and sedation</p> Signup and view all the answers

Why have SSRIs largely replaced TCAs and monoamine oxidase inhibitors (MAOIs) in treating depression?

<p>Because SSRIs are relatively safe even in overdose</p> Signup and view all the answers

What is the primary therapeutic action of SSRIs in the treatment of depression?

<p>Blocking the reuptake of serotonin</p> Signup and view all the answers

What is the minimum time typically required for the full therapeutic effect of SSRIs to be realized?

<p>4 weeks</p> Signup and view all the answers

Which of the following is NOT an indication for the use of SSRIs?

<p>Insomnia</p> Signup and view all the answers

Why is it important to consider individual patient responses when choosing an SSRI?

<p>To ensure optimal therapeutic effects</p> Signup and view all the answers

Which of the following is a common misconception regarding SSRIs?

<p>Patients will respond the same to any SSRI prescribed</p> Signup and view all the answers

'University of Baghdad/College of Medicine 2022-2023' provides information about:

<p><i>A list of SSRIs commonly used</i></p> Signup and view all the answers

Which neurotransmitters are primarily affected by bupropion?

<p>Dopamine and norepinephrine</p> Signup and view all the answers

What is a significant side effect associated with the use of bupropion?

<p>Increased risk for seizures</p> Signup and view all the answers

How does mirtazapine primarily affect neurotransmission?

<p>By serving as an antagonist at presynaptic α2 receptors</p> Signup and view all the answers

What distinguishes mirtazapine from other antidepressants in terms of side effects?

<p>Is sedating due to its antihistaminic activity</p> Signup and view all the answers

Which atypical antidepressant is specifically mentioned for its usefulness in patients trying to quit smoking?

<p>Bupropion</p> Signup and view all the answers

What group of agents do atypical antidepressants belong to?

<p>Mixed group with actions at different sites</p> Signup and view all the answers

Why should the use of bupropion be avoided in some patients?

<p>Risk for seizures</p> Signup and view all the answers

What differentiates bupropion from SSRIs in terms of side effects?

<p>Has a low incidence of sexual dysfunction</p> Signup and view all the answers

Which antidepressant is known for its sedating effect and is commonly used for insomnia?

<p>Trazodone</p> Signup and view all the answers

What is the main reason behind the sedating effect of Nefazodone and Trazodone?

<p>Histamine H1 blocking activity</p> Signup and view all the answers

Which statement about the absorption of SSRIs after oral administration is correct?

<p>Sertraline absorption is increased by food intake.</p> Signup and view all the answers

Which antidepressant has been associated with a risk for hepatotoxicity?

<p>Nefazodone</p> Signup and view all the answers

What is the main route of excretion for SSRIs?

<p>Urine</p> Signup and view all the answers

Why is Vilazodone unique compared to SSRIs?

<p>5-HT1a partial agonism</p> Signup and view all the answers

What is the suggested mechanism of action for Vortioxetine in treating depression?

<p>5-HT1a agonism and 5-HT3/5-HT7 antagonism</p> Signup and view all the answers

Which SSRIs are potent inhibitors of CYP2D6 isoenzyme?

<p>Fluoxetine and paroxetine</p> Signup and view all the answers

Which antidepressant is specifically mentioned to have a risk for priapism?

<p>Trazodone</p> Signup and view all the answers

What is a contraindication for the use of SSRIs?

<p>Allergy to any of the SSRIs</p> Signup and view all the answers

What contributes to orthostasis and dizziness with Nefazodone and Trazodone use?

<p>Mild to moderate α1 receptor antagonism</p> Signup and view all the answers

Why should caution be used with severely depressed or suicidal patients when prescribing SSRIs?

<p>Risk of increased suicidality</p> Signup and view all the answers

What should be considered when prescribing SSRIs to pregnant women?

<p>Benefits to the mother should outweigh potential risks to the fetus</p> Signup and view all the answers

What is a common adverse effect profile shared by Vilazodone with SSRIs?

<p>'Discontinuation syndrome' risk if abruptly stopped</p> Signup and view all the answers

What effect can SSRIs in breast milk have on babies?

<p>Negative adverse effects on babies</p> Signup and view all the answers

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