18 Questions
What initiates the proliferation of T lymphocytes that recognize antigens?
Binding of IL-2 to its receptor
What is the role of B7 in the activation of T cells by class II MHC Antigen-presenting cells?
Provides a costimulatory signal to T cells
Which protein functions as a costimulatory molecule on antigen-presenting cells to activate CD4+ T cells?
ICAM-1
What is the major T cell integrin involved in binding to antigen-presenting cells?
LFA-1
What happens if a naïve T cell recognizes an antigen without co-stimulation?
Anergy
What is the end result of signal transduction in a T lymphocyte?
Gene transcription
Which molecule binds CD28 on the T cell surface to provide costimulatory signals?
B7 costimulatory proteins
What is the role of ICAM-1 on antigen-presenting cells interacting with CD4+ T cells?
Functions as a costimulatory molecule
What is the mechanism behind the activation of transcription factors after T cell recognition of antigens?
Recruitment of adaptor proteins at antigen recognition site
What happens if dendritic cells cross-present antigens to CD8+ cells?
Activation of CD8+ cytotoxicity
What is the effector function of CD8+ T cells compared to macrophages or CD4+ T cells?
Killing infected cells with microbial antigens in the cytosol
What is the specific effector function of CD4+ Th2 subset cells?
Recruiting eosinophils to destroy helminthic parasites
Which type of T cells recruit and activate other leukocytes to phagocytose and destroy microbes?
CD4+ helper T cells
What is the role of CD8+ T cells in inducing inflammation?
Producing cytokines that recruit leukocytes
Which subset of CD4+ T cells secretes cytokines that recruit leukocytes and activate phagocytes?
Th1 subset
What is the primary function of CD8+ cytotoxic T lymphocytes (CTLs) in the immune response?
Killing infected cells containing microbial proteins in the cytosol
What distinguishes the effector function of CD4+ Th2 subset from other T cell subsets?
Recruiting eosinophils for parasitic defense
Which leukocytes are primarily recruited by CD4+ Th1 and Th17 subsets?
Neutrophils
Test your knowledge on the effector functions of activated CD8+ T cells compared to macrophages and CD4+ T cells. Learn about how different T cell subsets recognize microbial antigens and contribute to immune responses.
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