Serum Albumin Functions

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What is the main function of serum albumin in the blood?

Regulating blood volume by maintaining the oncotic pressure

What are some molecules that serum albumin acts as a carrier for?

Lipid-soluble hormones, bile salts, unconjugated bilirubin, free fatty acids

In which conditions does serum albumin level decrease?

Physiologically in late pregnancy, pathologically in liver disease, nephrotic syndrome, burns, protein-losing enteropathy, malabsorption, malnutrition, genetic variations, malignancy, increased catabolism in fever, untreated DM, and hypertension

What is the principle behind using Bromocresol green as an indicator for serum albumin?

It changes color from yellow to blue-green when it binds to albumin

What is the normal range of serum albumin in adults aged 20-60 years?

3.5 - 5.2 g/dl

How does prolonged venous stasis or dehydration affect serum albumin levels?

They can artifactually raise serum albumin levels

What is the main source of production of serum albumin in the body?

Liver

What is the purpose of using unhaemolytic serum or plasma for collecting specimens for serum albumin testing?

To ensure accurate results and prevent hemolysis

What is creatinine and how is it eliminated from the body?

Creatinine is a chemical waste product in the blood that is eliminated by the kidneys in urine.

How is creatine related to creatinine synthesis in the body?

Creatinine is produced as a waste product of creatine and creatine phosphate.

What leads to a low level of creatinine clearance?

Abnormal kidney function.

What factors determine plasma creatinine concentration?

Relative muscle mass, rate of creatine turnover, and renal function.

What is the diagnostic importance of creatinine in evaluating kidney function?

To assess kidney function.

How is creatine synthesized in the body?

Creatine is synthesized in the liver from arginine, glycine, and methionine.

What is the function of creatine phosphate in muscle tissue?

It serves as a high-energy source for muscle tissue.

What is the relationship between creatine phosphate and creatinine production?

Creatinine is produced as a waste product of creatine phosphate breakdown.

How is creatinine eliminated from the body?

Creatinine is filtered by the glomerulus and excreted in urine.

Why is daily creatinine excretion considered fairly stable?

Because creatinine is released into circulation at a stable rate proportional to muscle mass.

Learn about the importance and functions of serum albumin, the most abundant blood plasma protein produced in the liver. Discover how it regulates blood volume by maintaining oncotic pressure and serves as carriers for molecules of low water solubility.

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