Salbutamol and Beta2-Adrenoceptor Quiz

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23 Questions

What is the primary mediator of the second phase of asthmatic attacks?

Histamine

Why is a low FEV1 considered a useful metric of airflow limitation?

It indicates bronchoconstriction.

What is the purpose of pharmacological control of bronchial smooth muscle tone?

To minimize side effects of drugs

What is the advantage of inhalation of drugs for airflow limitation compared to oral administration?

Reduced side effects

Which method maximizes drug inhalation during inhaler use?

Use of spacer

Which statement regarding Salbutamol is FALSE?

Salbutamol should be given intravenously

What is the primary mechanism of action of muscarinic receptor antagonists like ipratropium bromide?

Inhibition of muscarinic receptors

Which condition are methylxanthines such as theophylline and aminophylline more commonly used for?

COPD

What is a common side effect associated with methylxanthines like theophylline?

Nausea

Which drug combination shows an additive effect on change in FEV1?

Ipratropium bromide and albuterol (salbutamol)

Which statement about the effect of selective Beta2 adrenoceptor agonists on Beta1 receptors is TRUE?

They have no action on Beta1 receptors

Which of the following is not a common trigger for asthma?

Bacterial infections

What is the primary cause of chronic obstructive pulmonary disease (COPD)?

Cigarette smoking

Which class of bronchodilator drugs acts on β-adrenoceptors?

β-Adrenoceptor agonists

What is the distinguishing feature between asthma and COPD in terms of lung function?

COPD causes chest hyperinflation while asthma does not

Which term describes the episodic bouts of airflow limitation seen in asthma?

Bronchospasm

Why is chronic obstructive pulmonary disease (COPD) considered irreversible?

Irreversible damage to the airways and lung function loss occur

Which type of adrenoceptor agonist is salbutamol?

Beta2

What is the main side effect related to the stimulation of Beta1 receptors by salbutamol and terbutaline?

Tachycardia

Why is regularly scheduled use of short-acting adrenoceptor agonists generally not recommended?

May increase airway hyperresponsiveness

Which long-acting β-adrenoceptor agonist has a slower onset of action?

Salmeterol

What caution should be taken with long-acting β-adrenoceptor agonists like salmeterol?

May decrease responsiveness to short-acting Beta2 agonists

What is the most effective medication for the relief of acute bronchospasm?

Salbutamol

Test your knowledge on salbutamol, its mechanism of action on beta2-adrenoceptors in airway smooth muscle cells, and its effects on cAMP levels. Explore the selectivity of short-acting adrenoceptor agonists like salbutamol and their effectiveness in treating bronchospasm.

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