Pharmacology: Noradrenaline and Salbutamol Mechanism of Action

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Questions and Answers

Which of the following is a side effect associated with adrenaline on the central nervous system?

  • Tremors (correct)
  • Tachycardia
  • Hypertension
  • Cardiac arrest

What is the primary therapeutic use of adrenaline when given by subcutaneous injection with local anesthetics?

  • Decrease bleeding (correct)
  • Decrease systemic absorption
  • Treat hypertension
  • Prolong duration of action of anesthetic

In which emergency situation would adrenaline be administered by inhalation or subcutaneously?

  • Diabetes mellitus
  • Acute bronchial asthma (correct)
  • Anaphylactic shock
  • Cardiac arrest

Why are patients with hyperthyroidism contraindicated from receiving adrenaline?

<p>To prevent cerebral hemorrhage (D)</p> Signup and view all the answers

What is the primary mechanism of action of adrenaline at the adrenergic receptors?

<p>Direct agonist at all types of adrenergic receptors (B)</p> Signup and view all the answers

Why are patients using non-selective beta blockers contraindicated from receiving adrenaline?

<p>It may lead to a massive increase in blood pressure (D)</p> Signup and view all the answers

What is the main mechanism of action of noradrenaline (norepinephrine)?

<p>Agonist on alpha receptors in blood vessels (D)</p> Signup and view all the answers

What is the mechanism of action of nasal decongestants like phenylephrine and oxymetazoline?

<p>Activation of alpha-1 adrenoceptors in the arterioles of the nasal mucosa (D)</p> Signup and view all the answers

Which side effect is NOT associated with the use of salbutamol (albuterol)?

<p>Bradycardia (D)</p> Signup and view all the answers

What is rebound congestion, a common side effect of nasal decongestants?

<p>Inflammation of the nasal mucosa caused by overuse (A)</p> Signup and view all the answers

Why should long-term use of beta-2 agonists like salbutamol be combined with ICS in asthma treatment?

<p>To minimize bronchial hyperresponsiveness (B)</p> Signup and view all the answers

Which age group is contraindicated to use intranasal phenylephrine due to the risk of life-threatening hypertension?

<p>Children under 2 years (A)</p> Signup and view all the answers

How long can it take for rebound congestion to resolve after stopping decongestant use?

<p>Up to 1 year (D)</p> Signup and view all the answers

What is the main use of midodrine (prodrug of methoxamine)?

<p>Treatment of low blood pressure (A)</p> Signup and view all the answers

What is a potential side effect associated with using nasal sprays containing phenylephrine for an extended period?

<p>Hypertension (D)</p> Signup and view all the answers

Which statement best describes the mechanism of action of phenylephrine?

<p>Acts as a selective alpha-1 agonist on blood vessels (A)</p> Signup and view all the answers

Which effect is NOT attributed to the use of beta-2 agonists like formoterol?

<p>Decrease in vascular permeability (D)</p> Signup and view all the answers

What is the primary purpose of intranasal saline as a decongestant in infants?

<p>To reduce inflammation in the nasal mucosa (B)</p> Signup and view all the answers

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