203: Symposium: Systemic Inflammatory Disease

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What is the specificity of anti-cyclic citrullinated peptide (anti-CCP) antibodies in detecting RA?

98%

In patients with RA, what is the main target of antibodies directed against CCP?

Citrullinated self proteins

Which of the following is true about rheumatoid factor (RF) in the context of RA?

Found in some healthy individuals

What is the role of citrullination in rheumatoid arthritis pathogenesis?

Induces antibody response against self proteins

Which of the following statements is true regarding the presence of anti-cyclic citrullinated peptide (anti-CCP) antibodies in healthy individuals?

Rarely found in those who go on to develop RA

How do anti-CCP+ RA patients generally compare in terms of disease course when compared to RF+ RA patients?

More aggressive clinical course

Which cell type is enriched in the RA joint but has a defect in their suppressive function?

T regulatory cells

Which treatment effectively depletes follicular B cells in RA?

Monoclonal anti-CD20 antibodies

Which immune cells are key effectors in RA, responsible for phagocytosis, antigen presentation, and cytokine production?

Macrophages

What contributes to the complex cellular interactions in rheumatoid arthritis according to Smolen et al.?

Genetic and non-genetic risk factors

Which antibody type is usually present before the onset of symptoms in RA?

Cyclic citrullinated peptide (anti-CCP) antibodies

What is reversed by blocking TNF according to the text provided?

Defect in T regulatory cell suppressive function

Which factor has been suggested as one of the initiating causes of Rheumatoid Arthritis (RA)?

Citrullination process triggered by bacterial infections

What is the main effect of anti-CCP antibodies in Rheumatoid Arthritis (RA)?

Promotion of osteoclast differentiation and activation

Which cells undergo a special form of cell death called 'NETosis' in the context of Rheumatoid Arthritis (RA)?

Neutrophils

What is the primary composition of synovial tissue in Rheumatoid Arthritis (RA)?

Macrophages (40%), Fibroblast and endothelial cells (10-15%), T lymphocytes (40%)

Which molecular mechanism leads to joint space narrowing in Rheumatoid Arthritis (RA)?

Enhanced NETosis with release of citrullinated proteins

What effect does citrullinated protein release through NETosis have on Rheumatoid Arthritis (RA)?

'NETosis' leads to biomechanical dysfunction and bone erosion

Which mechanism is proposed to explain the role of anti-CCP immune complexes in enhancing inflammation in mice with mild synovitis?

Activation of inflammatory cells

What is a potential effect of anti-CCP immune complexes in inducing inflammation in the context of rheumatoid arthritis?

Production of NETs by neutrophils

How do anti-CCP immune complexes contribute to the development and severity of inflammation in mice with mild synovitis?

By activating inflammatory cells

What is a potential consequence of anti-CCP immune complexes interacting with inflammatory cells?

Activation of osteoclast differentiation

How do anti-CCP immune complexes contribute to the severity of inflammation in mice with mild synovitis?

By enhancing NET production from neutrophils

Which process is implicated in the ability of anti-CCP immune complexes to exacerbate inflammation in cases where mild synovitis is present?

Inducing citrullination of proteins

What is the primary characteristic of rheumatoid arthritis (RA) compared to healthy inflammation?

Occurrence of joint destruction

Which autoantibodies are often present in individuals with RA?

Rheumatoid factor (RF)

What is the significance of Cyclic citrullinated peptide (anti-CCP) antibodies in RA?

They accelerate joint destruction

How do women differ from men in terms of risk related to autoimmunity in RA?

Women are at a higher risk of developing autoimmunity

What does citrullination refer to in the context of RA?

A process involving the conversion of arginine to citrulline

How does the presence of anti-CCP antibodies impact the diagnosis and management of RA?

It increases the accuracy of diagnosis when combined with other clinical tests

Test your knowledge on the pathogenesis of rheumatoid arthritis, including the role of IL-17, T regulatory cells, B cells, and auto-antibodies. Learn about the interactions between different immune cells in the development of RA.

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