Respiratory Pharmacology 2 Prof LJ Egan Lecture Outline

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What are the local side effects associated with inhaled corticosteroids?

Dysphonia, oropharyngeal candidiasis, cough

Which immune cells are glucocorticoid receptors ubiquitously expressed in?

T lymphocytes

What is the main advantage of using inhaled corticosteroids in asthma and COPD?

Target the inflammatory phase of airflow limitation

Which medication is an example of a cysteinyl leukotriene receptor antagonist used in asthma?

Montelukast

What is the effect of montelukast on FEV1 in patients with asthma?

Improves airflow in both early and late phases

How do anti-IgE therapies work in the treatment of asthma?

Block IgE receptors to reduce allergic response

What is the main characteristic of asthma patients who are suitable candidates for Omalizumab treatment?

High total serum IgE levels

Which of the following is a common trigger for severe asthma attacks?

House dust mites

What is the recommended initial treatment for severe asthma attacks that are unresponsive to bronchodilators?

Systemic corticosteroids

What is the significance of 'status asthmaticus' in severe asthma attacks?

It signifies an attack unresponsive to initial treatments

In the context of asthma management, what is the role of short-acting Beta agonists?

Providing symptomatic relief

Why are systemic corticosteroids considered life-saving in severe asthma attacks?

They help reduce airway inflammation and improve lung function

What was the historical treatment of asthma in the early 1900s?

Inhaled epinephrine

Which type of drugs focuses on mast cell stabilizers in the treatment of asthma?

Anti-IgE antibody therapy

What did the peaks of asthma mortality in England and Australia in 1966 highlight?

Excessive reliance on inhaled bronchodilators

What was the spirometry result for the 16-year-old girl with asthma mentioned in the text?

FEV1 60% of predicted

Which type of receptor is targeted by corticosteroids to produce their metabolic and immune effects?

Glucocorticoid receptor

What event in New Zealand in 1977 emphasized inadequate treatment due to excessive reliance on certain medications?

Excessive use of inhaled beta agonists and oral theophylline

Explore the outline of a lecture on respiratory pharmacology by Professor LJ Egan, covering topics such as anti-inflammatory drugs in asthma, step-wise therapeutic approaches, historical treatments, and more.

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