Platelet Aggregation Inhibitors: Clopidogrel and Ticlopidine Quiz
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Platelet Aggregation Inhibitors: Clopidogrel and Ticlopidine Quiz

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@TougherMint

Questions and Answers

What is the mechanism of action of platelet aggregation inhibitors like Clopidogrel and Ticlopidine?

Blocking binding sites on GPIIb/IIIa receptors

Which platelet aggregation inhibitor is a monoclonal antibody?

Abciximab

What is the mechanism of action of Dipyridamole?

Increasing adenosine levels and blocking fibrinogen binding

Which platelet aggregation inhibitor is indicated for reducing symptoms of intermittent claudication?

<p>Cilostazol</p> Signup and view all the answers

What do anticoagulants like Heparin and LMWH primarily target in the coagulation cascade?

<p>Thrombin (Factor II)</p> Signup and view all the answers

Why are LMWHs considered favorable for pregnant women?

<p>They have a predictable anticoagulant effect</p> Signup and view all the answers

Which anticoagulant is initially used as rat poison?

<p>Warfarin</p> Signup and view all the answers

What is the mechanism of action of thrombolytic agents like Alteplase and Streptokinase?

<p>Directly inhibiting thrombin</p> Signup and view all the answers

What is the primary adverse effect of thrombolytic agents like Streptokinase?

<p>Hemorrhage</p> Signup and view all the answers

Which factor is responsible for the formation of a hemostatic plug by stabilizing inactive GP IIb/ IIIa receptors?

<p>Prostacyclin</p> Signup and view all the answers

What effect does acetylsalicylic acid (ASA) have on COX-1?

<p>It prevents arachidonate from binding to the active site.</p> Signup and view all the answers

What is the main role of thrombolytic drugs in the context of clot formation?

<p>Limiting the growth of the clot and dissolving fibrin network</p> Signup and view all the answers

Which drug inhibits the binding of Adenosine diphosphate (ADP), thereby preventing the activation of GIIb/IIIa receptors?

<p>Clopidogrel (Plavix)</p> Signup and view all the answers

What is the primary function of Factor XIII in the coagulation cascade?

<p>Promoting fibrin formation</p> Signup and view all the answers

Which agent acts by irreversibly acetylating a serine on COX-1, leading to inhibition of thromboxane A2 synthesis?

<p>Acetylsalicylic Acid (ASA)</p> Signup and view all the answers

What effect does prostacyclin have on platelet function?

<p>Decreases intracellular Ca2+ levels</p> Signup and view all the answers

Which drug is considered a hemorheologic agent?

<p>Dipyridamole</p> Signup and view all the answers

What is the primary effect of Factor XIII in the coagulation cascade?

<p>Promotion of fibrin formation</p> Signup and view all the answers

Which condition can be prevented or treated using platelet aggregation inhibitors?

<p>Ischemic Strokes</p> Signup and view all the answers

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