Platelet Aggregation Inhibitors: Clopidogrel and Ticlopidine Quiz

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19 Questions

What is the mechanism of action of platelet aggregation inhibitors like Clopidogrel and Ticlopidine?

Blocking binding sites on GPIIb/IIIa receptors

Which platelet aggregation inhibitor is a monoclonal antibody?


What is the mechanism of action of Dipyridamole?

Increasing adenosine levels and blocking fibrinogen binding

Which platelet aggregation inhibitor is indicated for reducing symptoms of intermittent claudication?


What do anticoagulants like Heparin and LMWH primarily target in the coagulation cascade?

Thrombin (Factor II)

Why are LMWHs considered favorable for pregnant women?

They have a predictable anticoagulant effect

Which anticoagulant is initially used as rat poison?


What is the mechanism of action of thrombolytic agents like Alteplase and Streptokinase?

Directly inhibiting thrombin

What is the primary adverse effect of thrombolytic agents like Streptokinase?


Which factor is responsible for the formation of a hemostatic plug by stabilizing inactive GP IIb/ IIIa receptors?


What effect does acetylsalicylic acid (ASA) have on COX-1?

It prevents arachidonate from binding to the active site.

What is the main role of thrombolytic drugs in the context of clot formation?

Limiting the growth of the clot and dissolving fibrin network

Which drug inhibits the binding of Adenosine diphosphate (ADP), thereby preventing the activation of GIIb/IIIa receptors?

Clopidogrel (Plavix)

What is the primary function of Factor XIII in the coagulation cascade?

Promoting fibrin formation

Which agent acts by irreversibly acetylating a serine on COX-1, leading to inhibition of thromboxane A2 synthesis?

Acetylsalicylic Acid (ASA)

What effect does prostacyclin have on platelet function?

Decreases intracellular Ca2+ levels

Which drug is considered a hemorheologic agent?


What is the primary effect of Factor XIII in the coagulation cascade?

Promotion of fibrin formation

Which condition can be prevented or treated using platelet aggregation inhibitors?

Ischemic Strokes

Test your knowledge on platelet aggregation inhibitors, specifically Clopidogrel (Plavix®) and Ticlopidine (Ticlid®). Learn about the adverse effects, indications, and differences between the two medications.

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