Clopidogrel Platelet Aggregation Quiz
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Questions and Answers

What is the usual loading dose of Clopidogrel?

  • 150 mg
  • 300 mg (correct)
  • 600 mg
  • 75 mg
  • When is the maximum inhibition of platelet aggregation achieved with repeated doses of 75 mg/d Clopidogrel?

  • Within 1-2 days
  • Within 10 days
  • Within 3-7 days (correct)
  • Within 24 hours
  • What is the duration of platelet inhibition with Clopidogrel?

  • 24 hours
  • 7-10 days (correct)
  • 14-21 days
  • 3-5 days
  • In which patient population is dual antiplatelet therapy with Clopidogrel and aspirin commonly used?

    <p>Patients with atherosclerosis or acute coronary syndrome</p> Signup and view all the answers

    What role does Clopidogrel play in patients with atrial fibrillation who cannot take vitamin K antagonists?

    <p>It prevents clot formation</p> Signup and view all the answers

    What do prescribers use Clopidogrel as an alternative antiplatelet drug for?

    <p>Patients who cannot tolerate aspirin</p> Signup and view all the answers

    Which adverse effect is commonly associated with clopidogrel use?

    <p>Pruritus</p> Signup and view all the answers

    What is a contraindication to the use of clopidogrel?

    <p>Active bleeding conditions</p> Signup and view all the answers

    Which population group is more likely to experience bleeding and complications with antiplatelet drugs like clopidogrel?

    <p>Older adults</p> Signup and view all the answers

    What is a potential consequence of clopidogrel accumulation in individuals with hepatic impairment?

    <p>Increased risk of hemorrhagic stroke</p> Signup and view all the answers

    What is recommended for CYP2C19 poor or intermediate metabolizers due to variant forms of the enzyme?

    <p>Switch to a different antiplatelet therapy</p> Signup and view all the answers

    Why is caution needed when using clopidogrel in pregnant women?

    <p>It can lead to miscarriage</p> Signup and view all the answers

    What is the primary enzyme responsible for converting Clopidogrel to its active form?

    <p>CYP2C19 enzymes</p> Signup and view all the answers

    Which of the following are considered shortcomings of Clopidogrel?

    <p>Delayed onset of action</p> Signup and view all the answers

    What is the mechanism of action of Clopidogrel?

    <p>Irreversibly blocking the ADP receptor on platelet cell surface</p> Signup and view all the answers

    When does platelet inhibition typically occur after a single dose of Clopidogrel?

    <p>2 hours after administration</p> Signup and view all the answers

    In what way is Clopidogrel similar to aspirin in terms of its effect on platelets?

    <p>Both have antiplatelet effects but Clopidogrel has delayed onset of action</p> Signup and view all the answers

    Which enzyme is responsible for the metabolism of Clopidogrel to its active form to a lesser extent?

    <p>CYP3A4 enzymes</p> Signup and view all the answers

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