18 Questions
What is the usual loading dose of Clopidogrel?
300 mg
When is the maximum inhibition of platelet aggregation achieved with repeated doses of 75 mg/d Clopidogrel?
Within 3-7 days
What is the duration of platelet inhibition with Clopidogrel?
7-10 days
In which patient population is dual antiplatelet therapy with Clopidogrel and aspirin commonly used?
Patients with atherosclerosis or acute coronary syndrome
What role does Clopidogrel play in patients with atrial fibrillation who cannot take vitamin K antagonists?
It prevents clot formation
What do prescribers use Clopidogrel as an alternative antiplatelet drug for?
Patients who cannot tolerate aspirin
Which adverse effect is commonly associated with clopidogrel use?
Pruritus
What is a contraindication to the use of clopidogrel?
Active bleeding conditions
Which population group is more likely to experience bleeding and complications with antiplatelet drugs like clopidogrel?
Older adults
What is a potential consequence of clopidogrel accumulation in individuals with hepatic impairment?
Increased risk of hemorrhagic stroke
What is recommended for CYP2C19 poor or intermediate metabolizers due to variant forms of the enzyme?
Switch to a different antiplatelet therapy
Why is caution needed when using clopidogrel in pregnant women?
It can lead to miscarriage
What is the primary enzyme responsible for converting Clopidogrel to its active form?
CYP2C19 enzymes
Which of the following are considered shortcomings of Clopidogrel?
Delayed onset of action
What is the mechanism of action of Clopidogrel?
Irreversibly blocking the ADP receptor on platelet cell surface
When does platelet inhibition typically occur after a single dose of Clopidogrel?
2 hours after administration
In what way is Clopidogrel similar to aspirin in terms of its effect on platelets?
Both have antiplatelet effects but Clopidogrel has delayed onset of action
Which enzyme is responsible for the metabolism of Clopidogrel to its active form to a lesser extent?
CYP3A4 enzymes
Test your knowledge on the effects of clopidogrel on platelet aggregation. Learn about the timing of onset of action, dosages, and duration of platelet inhibition. Explore details on how platelet aggregation returns to baseline after discontinuing clopidogrel.
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