Questions and Answers
What is the initial step in the transition of a rolling leukocyte to firmly adhering?
Tethering of neutrophils to the endothelium
What is responsible for triggering the transition of a rolling leukocyte to firmly adhering?
Chemokines
What role do integrins play in the firm adhesion of leukocytes to the endothelium?
They bind firmly to their ligands
What is the main function of chemokines in the migration of leukocytes to sites of infection?
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Where are chemokines produced in the context of a site of infection?
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What is the ultimate result of the firm binding of integrins to their ligands on the endothelium?
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