Leukocyte Adhesion and Extravasation

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What is the initial step in the transition of a rolling leukocyte to firmly adhering?

Tethering of neutrophils to the endothelium

What is responsible for triggering the transition of a rolling leukocyte to firmly adhering?

Chemokines

What role do integrins play in the firm adhesion of leukocytes to the endothelium?

They bind firmly to their ligands

What is the main function of chemokines in the migration of leukocytes to sites of infection?

Promoting the movement of leukocytes from the blood into the tissues

Where are chemokines produced in the context of a site of infection?

By tissue macrophages and endothelial cells

What is the ultimate result of the firm binding of integrins to their ligands on the endothelium?

Arresting the rolling leukocytes on the endothelium

Learn about the transition of a rolling leukocyte to firmly adhering, involving the activation of integrins, binding to endothelial ligands, and the role of chemokines in triggering this process. Understand how leukocyte extravasation into tissues is essential for the immune response.

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