Drug Metabolism Quiz

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12 Questions

Which mechanism of drug absorption typically involves transfer across most biological membranes?

Passive diffusion

Which process involves drug transfer from the site of administration to the bloodstream?

Absorption

What type of diffusion involves carrier proteins but does not require energy?

Facilitated diffusion

Which of the following routes of drug administration is NOT mentioned in the text?

Intramuscular injection

Which type of reactions involve amine oxidation and alcohol dehydrogenation in drug metabolism?

Phase I reactions

Inhibition of CYP450 can lead to serious adverse events. Which of the following is NOT an inhibitor of CYP450 according to the text?

Ibuprofen

Which of the following is NOT a substance that can lead to increased toxic effects when combined with drugs like nifedipine and simvastatin?

Ritonavir

Which of the following groups allows drugs to enter phase II directly without prior phase I metabolism?

-OH group

Which set of reactions involves introducing or unmasking a polar functional group in drug metabolism?

Phase I

Where are the cytochrome P450 isozymes primarily located?

Liver and GI tract

Which type of drugs or environmental pollutants may induce the activity of CYP450 isozymes?

Inducers

Which drug is mentioned as an example that can decrease concentrations of drugs metabolized by CYP450 isozymes?

Rifampin

Test your knowledge on drug metabolism and its effects on plasma drug concentrations and therapeutic drug effect. Learn about the impact of inhibitors like Omeprazole, Erythromycin, and Grapefruit juice on drug activity and potential adverse events.

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