Phase 2 Drug Metabolism Conjugation Quiz

Which conjugation pathway is important for the biosynthesis of endogenous amines like adrenaline?

Which conjugation pathway is minor but important in the biosynthesis of epinephrine and melatonin?

Which conjugation pathway is involved in the catabolism of noradrenaline, dopamine, serotonin, and histamine?

Which pathway reduces the polarity of substrates through methylation?

Which pathway involves the formation of quaternary ammonium salts?

Which enzyme system is involved in the metabolism of xeno-biotics?

Where in the human body are cytochrome P450 enzymes mainly located?

Which type of enzymes are referred to as monooxygenases, mixed function oxidases or cytochrome P450?

Which enzyme system catalyzes reactions involving the introduction of one atom of oxygen into the substrate and one into water?

In which tissue is the highest amount of human cytochrome P450 found?

Which enzyme system is responsible for mutagenic or carcinogenic effects?

Which conjugation reaction plays an important role in hepatoxicity and carcinogenicity on N-hydroxylamines?

Which of the following is the product of glycine conjugation of benzoic acid?

What is the function of acetylation in drug metabolism?

Which tripeptide is found virtually in all mammalian tissues and scavenges harmful electrophilic xenobiotics?

What metabolic process deactivates potent xenobiotics containing primary amino groups?

Which type of conjugation leads to amide bond formation with a variety of carboxylic acids, including aromatic and heterocyclic ones?

Which process provides atypical drug metabolism due to genetic polymorphisms?