Physiology of Hemostasis

What is the purpose of INR calculation?

To standardize PT results

Which of the following correlates with an ACT test?

More accurate than PTT if using a large dose of heparin

When should the ACT be measured after going on CPB?

3 minutes after going on CPB

What is the target INR for patients on warfarin?

Approximately 2-3 times more than the control Signup and view all the answers

Which of the following is correct regarding a Platelet Count?

Number of platelets in the body Signup and view all the answers

What is the primary role of platelets in hemostasis?

Forming a platelet plug Signup and view all the answers

Which of the following best describes the initial response to blood vessel damage in hemostasis?

Vascular spasm Signup and view all the answers

What is the main function of the fibrinolytic system in hemostasis?

Breaking down fibrin clots Signup and view all the answers

Which of the following involves the activation of tissue factor (TF) in hemostasis?

Extrinsic pathway Signup and view all the answers

What happens when there is no injury to blood vessels in terms of hemostasis?

Blood remains a liquid Signup and view all the answers

In which of the following vessels are hemostatic mechanisms less effective in dealing with bleeding?

Arteries Signup and view all the answers

What is the main role of the cell-based prothrombinase complex?

Convert prothrombin to thrombin Signup and view all the answers

Which of the following is a key function of thrombin in the coagulation process?

Convert fibrinogen to fibrin Signup and view all the answers

What is the role of the Factor VIIIa/IXa complex in the coagulation cascade?

Act as a cofactor for generation of large amounts of factor Xa Signup and view all the answers

What is the primary function of TFPI in the clotting process?

Neutralizes tissue factor Signup and view all the answers

Which of the following is a mechanism that limits the size of a clot in the coagulation process?

Activation of plasminogen Signup and view all the answers

How does the Fibrinolytic System regulate clot breakdown?

By turning off fibrinolysis when no longer needed Signup and view all the answers

What is the role of Factor XIII in the clotting cascade?

Stabilizes the fibrin meshwork Signup and view all the answers

Why are activated platelets considered essential for the clotting cascade?

They display receptors that bind clotting factors Signup and view all the answers

What is the function of thrombin in the clotting cascade?

Activates platelets Signup and view all the answers

In the classical clotting cascade, which pathway is activated when coagulation is initiated outside of the blood vessels?

Extrinsic pathway Signup and view all the answers

What occurs at the endpoint of both intrinsic and extrinsic pathways in the clotting cascade?

Thrombin production Signup and view all the answers

Which enzyme is synthesized in the liver and is inactive until needed to digest fibrin?

Plasminogen Signup and view all the answers

What is the role of tPA inhibitor (tPAI) in the fibrinolysis process?

Inhibits the conversion of plasminogen to plasmin Signup and view all the answers

Which test assesses the intrinsic and final common pathway of coagulation?

Activated Partial Thromboplastin Time (aPTT) Signup and view all the answers

What is the mechanism by which plasmin degrades fibrin?

It degrades fibrin into FDPs Signup and view all the answers

Which factor must be reduced by more than 30% before a change in Prothrombin Time (PT) is observed?

Factors in the extrinsic pathway Signup and view all the answers

What does Alpha-2 antiplasmin do in the context of fibrinolysis?

Inhibits the action of plasmin on fibrin Signup and view all the answers

INR stands for International Normalization Ratio.

True Signup and view all the answers

The normal value of INR is around 3.

False Signup and view all the answers

Activated Clotting Time (ACT) is measured after heparin administration only.

False Signup and view all the answers

Platelet Count measures the function of platelets.

False Signup and view all the answers

ACT should be greater than 400 seconds before going on CPB.

True Signup and view all the answers

Physiology of Hemostasis - Crow

Questions and Answers

What is the purpose of INR calculation?

Which of the following correlates with an ACT test?

When should the ACT be measured after going on CPB?

What is the target INR for patients on warfarin?

Which of the following is correct regarding a Platelet Count?

What is the primary role of platelets in hemostasis?

Which of the following best describes the initial response to blood vessel damage in hemostasis?

What is the main function of the fibrinolytic system in hemostasis?

Which of the following involves the activation of tissue factor (TF) in hemostasis?

What happens when there is no injury to blood vessels in terms of hemostasis?

In which of the following vessels are hemostatic mechanisms less effective in dealing with bleeding?

What is the main role of the cell-based prothrombinase complex?

Which of the following is a key function of thrombin in the coagulation process?

What is the role of the Factor VIIIa/IXa complex in the coagulation cascade?

What is the primary function of TFPI in the clotting process?

Which of the following is a mechanism that limits the size of a clot in the coagulation process?

How does the Fibrinolytic System regulate clot breakdown?

What is the role of Factor XIII in the clotting cascade?

Why are activated platelets considered essential for the clotting cascade?

What is the function of thrombin in the clotting cascade?

In the classical clotting cascade, which pathway is activated when coagulation is initiated outside of the blood vessels?

What occurs at the endpoint of both intrinsic and extrinsic pathways in the clotting cascade?

Which enzyme is synthesized in the liver and is inactive until needed to digest fibrin?

What is the role of tPA inhibitor (tPAI) in the fibrinolysis process?

Which test assesses the intrinsic and final common pathway of coagulation?

What is the mechanism by which plasmin degrades fibrin?

Which factor must be reduced by more than 30% before a change in Prothrombin Time (PT) is observed?

What does Alpha-2 antiplasmin do in the context of fibrinolysis?

INR stands for International Normalization Ratio.

The normal value of INR is around 3.

Activated Clotting Time (ACT) is measured after heparin administration only.

Platelet Count measures the function of platelets.

ACT should be greater than 400 seconds before going on CPB.

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