Types of Necrosis Quiz
7 Questions
13 Views

Choose a study mode

Play Quiz
Study Flashcards
Spaced Repetition
Chat to Lesson

Podcast

Play an AI-generated podcast conversation about this lesson

Questions and Answers

What causes enzymatic fat necrosis?

  • Acute pancreatitis (correct)
  • Breast surgery
  • Pancreatic cancer
  • Breast trauma

Which condition results in traumatic (non-enzymatic) fat necrosis?

  • Breast trauma (correct)
  • Pancreatic cancer
  • Systemic Lupus Erythematosus
  • Acute pancreatitis

What is the characteristic appearance of Fibrinoid necrosis under the microscope?

  • Dark staining with H&E
  • Brightly eosinophilic, hyaline-like deposition (correct)
  • Loss of nucleus
  • Presence of lipid droplets

Which type of hypersensitivity reaction is associated with Fibrinoid necrosis?

<p>Type III hypersensitivity (A)</p> Signup and view all the answers

Which form of cell death is characterized by a coordinated and internally programmed process?

<p>Apoptosis (D)</p> Signup and view all the answers

In which situation is necrosis typically accompanied by inflammation?

<p>Traumatic fat necrosis (B)</p> Signup and view all the answers

What distinguishes apoptosis from necrosis?

<p>'Cell suicide' mechanism (B)</p> Signup and view all the answers

Flashcards

Cause of enzymatic fat necrosis

Acute pancreatitis

Cause of traumatic fat necrosis

Breast trauma

Microscopic look of Fibrinoid necrosis

Brightly eosinophilic, hyaline-like deposition

Hypersensitivity reaction linked to Fibrinoid necrosis

Type III hypersensitivity

Signup and view all the flashcards

Apoptosis's defining characteristic

Programmed cell death

Signup and view all the flashcards

Necrosis & inflammation relationship

Necrosis often leads to inflammation

Signup and view all the flashcards

Distinction between apoptosis and necrosis

Apoptosis is a 'cell suicide' mechanism, while necrosis involves cell damage and is typically accompanied by inflammation

Signup and view all the flashcards

Study Notes

Types of Necrosis

  • Coagulative necrosis: most common type of necrosis, dead tissue architectures are preserved for at least a couple of days, caused by hypoxia, burns, and viral hepatitis.
  • Liquefactive necrosis: necrotic cells undergo complete digestion and liquefaction, high level of enzymatic activity on dead cells, commonly seen in tissue rich in lysosomal enzymes (brain) and suppurative inflammation (Pyogenic bacterial infections).
  • Caseous necrosis: unique form of cell death, tissue maintains a cheese-like appearance, grayish white, soft and friable, accompanied by granulomatous inflammation, seen in Mycobacterium tuberculosis infection.
  • Fat necrosis: necrosis of fatty tissue, two types: enzymatic fat necrosis and traumatic fat necrosis, seen in conditions like acute fatty liver in pregnancy and hepatotoxins.

Mechanism of Necrosis

  • Hypoxia leads to increased anaerobic glycolysis, accumulation of lactic acid, and denaturation of intracellular proteins (lysosomal enzymes).
  • Digestion of necrotic cells occurs through autolysis (digestion by its own enzymes) or heterolysis (digestion by enzymes secreted by other cells like neutrophils and macrophages).

Characteristics of Necrosis

  • Always accompanied by inflammatory reaction.
  • Result of a pathological condition.
  • Causes: hypoxia, pathogens, chemical and physical agents, immunological injury.
  • Morphological changes include nuclear changes (pyknosis, karyorrhexis) and cytoplasmic changes (protein denaturation, eosinophilic karyolysis).

Removal of Necrotic Tissue

  • Two mechanisms: autolysis and heterolysis.
  • Autolysis: digestion of necrotic tissue by its own enzymes (lysosomes).
  • Heterolysis: digestion by enzymes secreted by other cells (neutrophils, macrophages).

Studying That Suits You

Use AI to generate personalized quizzes and flashcards to suit your learning preferences.

Quiz Team

Description

Test your knowledge on different types of necrosis including coagulative and liquefactive necrosis. Learn about the causes, mechanisms, and characteristics of each type of necrosis.

More Like This

Cellular changes and adaptation 2
22 questions
Necrosis or Apoptosis
11 questions
Necrosis Quiz
10 questions

Necrosis Quiz

UsableRabbit avatar
UsableRabbit
Types of Necrosis
10 questions
Use Quizgecko on...
Browser
Browser