Podcast
Questions and Answers
____ refers to what the body does to the toxin while
____ refers to what the toxin does to the body
____ refers to what the body does to the toxin while ____ refers to what the toxin does to the body
Toxicokinetics ; Toxicodynamics
____: substances travel from entry site throughout the body
____: substances travel from entry site throughout the body
- Absorption
- Distribution (correct)
- Metabolism
- Excretion
____:substance or metabolites are removed from the body via waste
____:substance or metabolites are removed from the body via waste
- Absorption
- Distribution
- Metabolism
- Excretion (correct)
A Large VD (____) implies that the drug is mainly distributed into the tissues
A Large VD (____) implies that the drug is mainly distributed into the tissues
Which drug does NOT have a large VD?
Which drug does NOT have a large VD?
T/F: Drugs with small VD are mainly confined to blood compartment
T/F: Drugs with small VD are mainly confined to blood compartment
Which is NOT one of the organs primarily responsible for excretion and metabolism?
Which is NOT one of the organs primarily responsible for excretion and metabolism?
T/F: If an oral drug injures the epithelial barrier of the
gastrointestinal tract it will not affect absorption
T/F: If an oral drug injures the epithelial barrier of the gastrointestinal tract it will not affect absorption
If the concentration of drug in the blood increases and blood protein-binding capacity is exceeded, will this result in an INCREASED or DECREASED fraction of free drug and GREATER or LESSER toxic effect?
If the concentration of drug in the blood increases and blood protein-binding capacity is exceeded, will this result in an INCREASED or DECREASED fraction of free drug and GREATER or LESSER toxic effect?
An overdose of which drug would lead to tachycardia and hypertension?
An overdose of which drug would lead to tachycardia and hypertension?
T/F: If a patient was admitted to the E.R. for possible opioid overdose (has a large Vd), hemodialysis would be used as a treatment
T/F: If a patient was admitted to the E.R. for possible opioid overdose (has a large Vd), hemodialysis would be used as a treatment
Which drug could lead to a patient dying of cellular Hypoxia?
Which drug could lead to a patient dying of cellular Hypoxia?
T/F: If a poisoned patient is presenting with coma, seizures, or altered mental status the ABCDs should be used regardless of poison involved
T/F: If a poisoned patient is presenting with coma, seizures, or altered mental status the ABCDs should be used regardless of poison involved
Which of these is one the ABCDs of poisoning
Which of these is one the ABCDs of poisoning
Which of these could NOT be used for decontaminating the GI tract
Which of these could NOT be used for decontaminating the GI tract
Match the antidote to the poison
Match the antidote to the poison
T/F: Hemodialysis is more efficient than Peritoneal dialysis is enhancing elimination of most drugs
T/F: Hemodialysis is more efficient than Peritoneal dialysis is enhancing elimination of most drugs
If an individual was admitted to the E.R. and died from the loss of
respiratory reflexes which resulted in a coma then which of the following classifications is how the poisoned patient died?
If an individual was admitted to the E.R. and died from the loss of respiratory reflexes which resulted in a coma then which of the following classifications is how the poisoned patient died?
What is the normal range for anion gap?
What is the normal range for anion gap?
What is the toxic acetaminophen dose for children?
What is the toxic acetaminophen dose for children?
What is the antidote for Acetaminophen?
What is the antidote for Acetaminophen?
Which is NOT a treatment for Cyanide?
Which is NOT a treatment for Cyanide?
Match term to definition
Match term to definition
Being exposed to a hazard for two months would qualify as which duration?
Being exposed to a hazard for two months would qualify as which duration?
What does ED50 mean?
What does ED50 mean?
T/F: Increased therapeutic index means increased safety
T/F: Increased therapeutic index means increased safety
What would be the therapeutic index for a drug with an LD50 of 20 and ED50 of 2?
What would be the therapeutic index for a drug with an LD50 of 20 and ED50 of 2?
Calculate anion gap for the following patient: Na = 135 meq/l, K = 5 mEq/l, HCO3 = 10 mEq/l, Cl= 115 mEq/l
Calculate anion gap for the following patient: Na = 135 meq/l, K = 5 mEq/l, HCO3 = 10 mEq/l, Cl= 115 mEq/l
What's the margin of safety for a drug with an LD1 of 7 and an ED99 of 9
What's the margin of safety for a drug with an LD1 of 7 and an ED99 of 9
An anticoag clinic would be an example of which type of professional services
An anticoag clinic would be an example of which type of professional services
What is the leading cause of preventable injury-related death
What is the leading cause of preventable injury-related death
What drug is the #1 cause of acute liver failure in the US?
What drug is the #1 cause of acute liver failure in the US?
Acetaminophen has Antipyretic activity at serum
[APAP] of _____?
Acetaminophen has Antipyretic activity at serum [APAP] of _____?
What is the toxic dose for acute ingestion of APAP?
What is the toxic dose for acute ingestion of APAP?
Which would NOT lead to a person being at higher risk for APAP toxcitiy?
Which would NOT lead to a person being at higher risk for APAP toxcitiy?
Which is NOT a lab that needs to be monitored after APAP poisoning?
Which is NOT a lab that needs to be monitored after APAP poisoning?
How long does Phase I of APAP poisoning last?
How long does Phase I of APAP poisoning last?
During which phase of APAP poisoning would liver necrosis occur?
During which phase of APAP poisoning would liver necrosis occur?
T/F: APAP levels should be drawn after 4 hours post ingestion
T/F: APAP levels should be drawn after 4 hours post ingestion
Which is a risk of activated charcoal?
Which is a risk of activated charcoal?
Which is true about sorbitol?
Which is true about sorbitol?
Which is NOT a Criteria for discontinuing NAC after APAP ingestion
Which is NOT a Criteria for discontinuing NAC after APAP ingestion
T/F: The 2 bag NAC Regimen is FDA approved
T/F: The 2 bag NAC Regimen is FDA approved
HD recommended with NAC in those with
[APAP] >____ with acidosis or altered consciousness
HD recommended with NAC in those with [APAP] >____ with acidosis or altered consciousness
Which is NOT a symptom seen in Aspirin toxicity?
Which is NOT a symptom seen in Aspirin toxicity?
What is the [Salicylate] to diagnose toxicity? 30 mg/dL
What is the [Salicylate] to diagnose toxicity? 30 mg/dL
Sodium bicarbonate is given to treat ___ during Salicylate toxicity?
Sodium bicarbonate is given to treat ___ during Salicylate toxicity?
If aspirin toxicity happens in a pregnant woman, ____ can occur to the fetus
If aspirin toxicity happens in a pregnant woman, ____ can occur to the fetus
___ is the most commonly used NSAIDs and the least toxic of the NSAIDs
___ is the most commonly used NSAIDs and the least toxic of the NSAIDs
What is the pediatric single dose toxcity for ibuprofen?
What is the pediatric single dose toxcity for ibuprofen?
Which is not a treatment option for NSAID poisoning?
Which is not a treatment option for NSAID poisoning?
Which poision would most likely cause severe blisters on eyes and skin?
Which poision would most likely cause severe blisters on eyes and skin?
What is the preferred treatment if a patient overdoses on an anticholinergic agent?
What is the preferred treatment if a patient overdoses on an anticholinergic agent?
What is the antidote for Anticholinesterase insecticides?
What is the antidote for Anticholinesterase insecticides?
