Questions and Answers
What is the primary goal of treatment for Thalassemia major?
To normalize Hgb
What is the purpose of deferoxamine in treating Hemosiderosis?
To bind excess iron for excretion by the kidney
What is the main purpose of splenectomy in Thalassemia major treatment?
To remove the site of hemolysis
What is the treatment approach for Thalassemia minor?
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What is the purpose of blood transfusions in Thalassemia major treatment?
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In Thalassemia major, what is the primary site of hemolysis that is targeted by splenectomy?
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What is the mechanism of action of deferoxamine in treating Hemosiderosis?
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Which of the following is a potential long-term complication of frequent blood transfusions in Thalassemia major?
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Which of the following is a definitive treatment for Thalassemia major?
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What is the main purpose of monitoring Hgb levels in Thalassemia major?
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Study Notes
Treatment of Thalassemia
Thalassemia Minor
- No intervention or monitoring is required
Thalassemia Major
- The goal of treatment is to normalize Hemoglobin (Hgb) levels
- Frequent blood transfusions are necessary to maintain normal Hgb levels
- Splenectomy is performed to eliminate the site of hemolysis
- Bone marrow transplant is a possible treatment option
- Hemosiderosis is a complication that can occur due to iron overload
- Hemosiderosis can be treated with iron-chelating drugs such as deferoxamine (Desferal)
- Deferoxamine binds excess iron for excretion by the kidney
Treatment of Thalassemia
Thalassemia Minor
- No intervention or monitoring is required
Thalassemia Major
- The goal of treatment is to normalize Hemoglobin (Hgb) levels
- Frequent blood transfusions are necessary to maintain normal Hgb levels
- Splenectomy is performed to eliminate the site of hemolysis
- Bone marrow transplant is a possible treatment option
- Hemosiderosis is a complication that can occur due to iron overload
- Hemosiderosis can be treated with iron-chelating drugs such as deferoxamine (Desferal)
- Deferoxamine binds excess iron for excretion by the kidney
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