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Questions and Answers
What serious complications can be associated with transfusion and disease in patients with β-thalassemia?
What serious complications can be associated with transfusion and disease in patients with β-thalassemia?
end-organ damage
In the 10-year follow-up period, what percentage of patients developed at least 1 comorbidity?
In the 10-year follow-up period, what percentage of patients developed at least 1 comorbidity?
- 76%
- 60%
- 78%
- 64% (correct)
Patients with α-thalassemia may experience complications that are different from patients with β-thalassemia.
Patients with α-thalassemia may experience complications that are different from patients with β-thalassemia.
False (B)
Greater transfusion burden is generally associated with more complications. Patients were grouped into transfusion burden severity cohorts based on average number of ______ units per 12 weeks.
Greater transfusion burden is generally associated with more complications. Patients were grouped into transfusion burden severity cohorts based on average number of ______ units per 12 weeks.
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Study Notes
β-Thalassemia Complications
- Transfusion-dependent (TD) patients with β-thalassemia are at risk of serious complications related to transfusion and disease, which can lead to end-organ damage.
- Over 10 years, 6% of patients developed at least 1 comorbidity, with cardiac disease being the most common (64% in the 45-49 year age group).
- Cardiac conditions in TD patients with β-thalassemia include atrial fibrillation, heart failure, and acute arrhythmia.
Transfusion Burden and Complications
- Greater transfusion burden is associated with more complications in TD patients with β-thalassemia.
- Patients were grouped into transfusion burden severity cohorts based on average number of RBC units per 12 weeks during follow-up: 0 RBC units, >0 to 12, 13-24, and ≥25 units.
- The study analyzed 612 TD patients with β-thalassemia, with comorbidities and mortality recorded over a 10-year period.
Study Design and Methodology
- The study used a retrospective analysis of ICD-10 diagnosis codes in the Hospital Episode Statistics database (admissions and outpatient attendance) at National Health Service hospitals in England.
- Patients were followed from their first hospital admission or outpatient appointment in 2009 until death in hospital, last hospital admission, or last outpatient appointment in 2018.
α-Thalassemia Complications
- Limited studies suggest that patients with α-thalassemia may experience complications similar to those of patients with β-thalassemia.
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