5 Questions
What is the characteristic of a patient with one α-globin gene deleted?
No anemia and asymptomatic
Which of the following is a characteristic of Hgb H disease?
Severe anemia at birth with an elevated Hgb Bart’s
What is the result of four α-globin genes being deleted?
Fetal hydrops
α-Thalassemia minor is characterized by?
Mild anemia
How many α-globin genes are deleted in Hgb H disease?
Three
Study Notes
Thalassemia
- A silent carrier has one α-globin gene deleted, resulting in no anemia and asymptomatic patients.
- α-Thalassemia minor occurs when two α-globin genes are deleted, leading to mild anemia in patients.
α-Globin Gene Deletions
- Deletion of three α-globin genes results in Hgb H disease, characterized by severe anemia at birth and an elevated Hgb Bart's.
- Complete deletion of four α-globin genes leads to fetal hydrops.
Learn about the effects of alpha-globin gene deletions on thalassemia, including silent carriers, alpha-thalassemia minor, Hgb H disease, and fetal hydrops. Understand the severity of anemia and resulting symptoms.
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