Alpha Thalassemia Quiz
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Questions and Answers

Which of the following accurately describes alpha thalassemia?

  • It results in excess alpha chains during fetal life
  • It involves a duplication of a gene
  • It is caused by a point mutation in a gene
  • It is characterized by the formation of tetramers like y4 and B4 (correct)

    • Which of the following best describes the a+- type of alpha thalassemia?

  • It results in a negative haplotype
  • It is a nondeletional mutation that affects regulation of a chain synthesis
  • It involves the absence of alpha-chain production
  • It is a deletion or mutation involving one of the duplicated alpha chains (correct)

    • Which of the following accurately describes the silent carrier type of alpha thalassemia?

  • It is characterized by a structural mutant
  • It results in a significant amount of Hgb Barts at birth
  • It involves a point mutation in a gene
  • It is a one gene deletion resulting in a very small amount of Hgb Barts at birth (correct)

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