Alpha Thalassemia Quiz

• It results in excess alpha chains during fetal life
• It involves a duplication of a gene
• It is caused by a point mutation in a gene
• It is characterized by the formation of tetramers like y4 and B4 (correct)

• It results in a negative haplotype
• It is a nondeletional mutation that affects regulation of a chain synthesis
• It involves the absence of alpha-chain production
• It is a deletion or mutation involving one of the duplicated alpha chains (correct)

• It is characterized by a structural mutant
• It results in a significant amount of Hgb Barts at birth
• It involves a point mutation in a gene
• It is a one gene deletion resulting in a very small amount of Hgb Barts at birth (correct)