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Questions and Answers
What is the estimated number of β-thalassemia–causing variants identified in the HBB gene?
What is the estimated number of β-thalassemia–causing variants identified in the HBB gene?
What is the result of reduced or absent production of β-globin in individuals with β-thalassemia?
What is the result of reduced or absent production of β-globin in individuals with β-thalassemia?
What is the composition of the predominant form of adult hemoglobin, HbA?
What is the composition of the predominant form of adult hemoglobin, HbA?
In which cells do unpaired α-globin chains accumulate in β-thalassemia?
In which cells do unpaired α-globin chains accumulate in β-thalassemia?
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What is the role of genetic context in the severity of β-thalassemia?
What is the role of genetic context in the severity of β-thalassemia?
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What type of mutation are β-thalassemia–causing variants often?
What type of mutation are β-thalassemia–causing variants often?
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Where are certain HBB mutations inherited more frequently?
Where are certain HBB mutations inherited more frequently?
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What is the consequence of an excess of unpaired α-globin chains?
What is the consequence of an excess of unpaired α-globin chains?
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What is the function of the HBB gene?
What is the function of the HBB gene?
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What is the result of the imbalance of α-globin to β-globin chain production?
What is the result of the imbalance of α-globin to β-globin chain production?
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