4.4 Physiology of GI Disorders Lecture

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27 Questions

Which condition is characterized by malabsorption due to gluten intolerance?

Celiac disease

Where are the vomiting centers located in the brain?

Medulla oblongata

What is a common risk factor for Postoperative Nausea and Vomiting (PONV)?

Obesity

Which receptors are typically targeted in the prophylaxis of Postoperative Nausea and Vomiting?

Serotonin receptors

What typically causes macrocytic pernicious anemia in individuals with severe malabsorption?

Diminished vitamin B12 and folic acid absorption

Which nutritional deficiency often results in osteomalacia due to lack of calcium?

Vitamin D deficiency

How do individuals with gluten enteropathy (celiac disease) benefit from eliminating gluten from their diet?

Cure within a week

What is the primary effect of gluten on the intestinal enterocytes in individuals with gluten enteropathy?

Destroys enterocytes

Which condition is most likely to cause nausea, cramping, dizziness, sweating, and a rapid heart rate after ingesting large volumes of sugary beverages post anastomosis of the jejunum to the stomach?

Dumping syndrome

What mechanism is primarily responsible for gastric ulcer formation?

Back-leak of hydrogen ions

In a patient experiencing frequent episodes of nausea, cramping, dizziness, sweating, and a rapid heart rate after consuming sugary beverages post-jejunum-stomach anastomosis, what is the likely diagnosis?

Dumping syndrome

Which area in the brain serves as a sensory circumventricular organ and lacks a blood-brain barrier?

Chemoreceptor trigger zone (CTZ)

Which receptors are involved in triggering impulses that lead to vomiting?

5-HT (serotonin) receptors

During vomiting, what happens to prevent aspiration?

Closing of the glottis

Which medication targets intracellular steroid receptors for controlling postoperative nausea and vomiting?

Dexamethasone

What is a risk factor for postoperative nausea and vomiting related to anesthesia?

History of PONV

What is the consequence of prolonged large intestinal obstruction?

Severe vomiting leading to rupture of the intestine

What can cause dehydration from vomiting large amounts of intestinal fluids?

Acidic vomitus due to pyloric obstruction

What is the primary cause of achalasia?

Failure of the lower esophageal sphincter (LES) to relax

Which condition results in the inability of food to reach the stomach due to a failure in the swallowing act?

Megaesophagus

How does chronic gastritis potentially lead to pernicious anemia?

Reduction in stomach secretions causing achlorhydria

What is a common cause of peptic ulcers?

Excessive secretion of acid and pepsin by gastric mucosa

What is the implication of loss of pancreatic secretion in conditions like pancreatitis?

Formation of fatty feces

Which condition involves gluten having a destructive effect on intestinal enterocytes?

Sprue

What is the main cause of tropical sprue?

Infectious agents

How do normal feedback controls ensure neutralization of gastric acid in the duodenum?

Inhibiting gastric secretion and peristalsis

How does gluten affect enterocytes in gluten enteropathy?

Destructive effect on intestinal enterocytes

This lecture outline covers disorders along the GI tract, nausea, vomiting, and objectives related to the physiology of GI disorders. Topics include esophageal disorders, gastritis, pancreatitis, gluten intolerance, dumping syndrome, causes of nausea and vomiting, and the brain's vomiting centers.

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