10 Questions
What is the enzyme responsible for the final cross-linking reaction in the cell wall biosynthesis?
Transpeptidase enzyme
What inhibits the final cross-linking reaction in the cell wall, leading to a leaky wall and cell lysis?
Penicillins and cephalosporins
What is the salt concentration like inside the cell compared to outside?
Greater inside the cell
What is the structure of the enzyme that catalyzes the final cross-linking reaction in the cell wall biosynthesis?
Thia zolidine ring
What is the chemical structure of penicillin G?
(2S,5R,6R)-6-acylamino-3,3dimethylpenam-2-carboxylic acid
What is the trivial nomenclature used for penicillins?
Penicillin as suffix and acyl portion (R) as prefix
What is the mechanism by which penicillins and cephalosporins inhibit cell wall biosynthesis?
Inhibiting the final cross-linking reaction
What is the consequence of inhibiting the final cross-linking reaction in the cell wall?
The cell wall becomes leaky
How do penicillins and cephalosporins cause cell lysis?
By allowing water to enter the cell
What is the role of D-alanine and glycine in the final step of cell wall biosynthesis?
Peptide chains are linked together
Test your knowledge on the reasons for the acid sensitivity of penicillin G. This quiz covers topics such as ring strain, reactive β-lactam carbonyl group, and the influence of the acyl chain in penicillin G.
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