18 Questions
Penicillin G is not sensitive to acid because of the influence of the acyl chain.
False
Penicillin V has better acid stability than penicillin G because of the absence of an electronegative oxygen on the acyl side chain.
False
Penicillin V is less active than penicillin G because it lacks an electronegative oxygen on the acyl side chain.
False
Ampicillin and oxacillin have better acid stability than penicillin G due to the influence of the acyl chain.
False
The acyl chain in penicillin V contributes to making it orally administrable.
True
Penicillin G and penicillin V share the same level of allergic sensitivity in individuals.
False
The enzyme responsible for the final cross-linking reaction in the cell wall biosynthesis is known as the transpeptidase enzyme.
True
Penicillins and cephalosporins inhibit the final cross-linking reaction in the cell wall biosynthesis, causing the cell wall framework to mesh together.
False
The salt concentration inside the cell is lower than those outside the cell, leading to water entering the cell and causing it to shrink.
False
The acyl chain in penicillins and cephalosporins is influential in inhibiting the final cross-linking reaction of the cell wall biosynthesis.
True
Derivatives of 6-aminopenicillanic acid (6-APA) have a trivial nomenclature that uses the acyl portion as suffix and the name penicillin as prefix.
False
Valine is an example of an acyl side chain commonly found in penicillins.
False
The mechanism of action of Penicillins and Cephalosporins involves inhibition of bacterial cell wall synthesis.
True
The acyl chain has no influence on the antibacterial action of Penicillins and Cephalosporins.
False
Monobactams contain a β-lactam ring in their structure.
True
Clavulanic acid is classified as a Penam-type antibiotic.
False
Antibiotics that belong to the Cephalosporins group do not have a β-lactam ring in their structure.
False
The cell wall of bacteria consists of peptidoglycan, which includes only sugar units.
False
This quiz discusses the acid sensitivity of penicillin G, specifically focusing on the reasons behind it such as ring strain, a highly reactive β-lactam carbonyl group, and the influence of the acyl chain. The quiz text also includes chemical structures and reactions related to penicillin G.
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