15 Questions
What is one of the three reasons for the acid sensitivity of penicillin G?
Ring strain
Which group in penicillin G is highly reactive and contributes to its acid sensitivity?
B-lactam carbonyl group
How does penicillin V differ from penicillin G in terms of its acyl side chain?
Penicillin V has an electronegative oxygen on the acyl side chain
What is the influence of the acyl chain in Penicillins and Cephalosporins?
It determines the spectrum of antimicrobial activity.
Which part of the antibiotics is responsible for the unique lethal antibacterial action in Penicillins and Cephalosporins?
The acyl chain
What is the main function of the cell wall in bacteria?
To regulate osmotic pressure
Which part of Penicillins and Cephalosporins is essential for inhibiting bacterial cell wall synthesis?
The acyl chain
What type of bonds are present in the peptidoglycan structure of bacterial cell walls?
'Glycosidic' bonds
Which textbook would be most useful for understanding the principles of medicinal chemistry related to antibiotics?
W.O. Foye, Principles of Medicinal Chemistry
Which enzyme is responsible for the final cross-linking reaction in cell wall biosynthesis?
Transpeptidase enzyme
How are penicillins and cephalosporins affecting the cell wall structure?
Inhibit the final cross-linking reaction
What happens to the cell when the cell wall becomes leaky due to the inhibition by penicillins and cephalosporins?
The cell swells and eventually lyses
Which molecule displaces D-alanine in one peptide chain during the final cross-linking reaction?
Glycine
What is the influence of penicillins and cephalosporins on the cell wall framework?
Prevent meshing of the cell wall framework
What specific part of the penicillin molecule plays a key role in influencing the antibiotic activity?
Acyl chain
Learn about the three reasons for the acid sensitivity of Penicillin G: Ring strain, a highly reactive β-lactam carbonyl group, and the influence of the acyl chain. Test your knowledge on the acid sensitivity of Penicillin G.
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