Podcast
Questions and Answers
What is one of the three reasons for the acid sensitivity of penicillin G?
What is one of the three reasons for the acid sensitivity of penicillin G?
- Strong acidic pH environment
- Ring strain (correct)
- Electronegative oxygen on the acyl side chain
- Highly reactive alkene group
Which group in penicillin G is highly reactive and contributes to its acid sensitivity?
Which group in penicillin G is highly reactive and contributes to its acid sensitivity?
- Acylation group
- B-lactam carbonyl group (correct)
- Tertiary amine group
- Alkene group
How does penicillin V differ from penicillin G in terms of its acyl side chain?
How does penicillin V differ from penicillin G in terms of its acyl side chain?
- Penicillin V has a positively charged acyl side chain
- Penicillin V has an electronegative oxygen on the acyl side chain (correct)
- Penicillin V has a larger acyl side chain
- Penicillin V has a less stable acyl side chain
What is the influence of the acyl chain in Penicillins and Cephalosporins?
What is the influence of the acyl chain in Penicillins and Cephalosporins?
Which part of the antibiotics is responsible for the unique lethal antibacterial action in Penicillins and Cephalosporins?
Which part of the antibiotics is responsible for the unique lethal antibacterial action in Penicillins and Cephalosporins?
What is the main function of the cell wall in bacteria?
What is the main function of the cell wall in bacteria?
Which part of Penicillins and Cephalosporins is essential for inhibiting bacterial cell wall synthesis?
Which part of Penicillins and Cephalosporins is essential for inhibiting bacterial cell wall synthesis?
What type of bonds are present in the peptidoglycan structure of bacterial cell walls?
What type of bonds are present in the peptidoglycan structure of bacterial cell walls?
Which textbook would be most useful for understanding the principles of medicinal chemistry related to antibiotics?
Which textbook would be most useful for understanding the principles of medicinal chemistry related to antibiotics?
Which enzyme is responsible for the final cross-linking reaction in cell wall biosynthesis?
Which enzyme is responsible for the final cross-linking reaction in cell wall biosynthesis?
How are penicillins and cephalosporins affecting the cell wall structure?
How are penicillins and cephalosporins affecting the cell wall structure?
What happens to the cell when the cell wall becomes leaky due to the inhibition by penicillins and cephalosporins?
What happens to the cell when the cell wall becomes leaky due to the inhibition by penicillins and cephalosporins?
Which molecule displaces D-alanine in one peptide chain during the final cross-linking reaction?
Which molecule displaces D-alanine in one peptide chain during the final cross-linking reaction?
What is the influence of penicillins and cephalosporins on the cell wall framework?
What is the influence of penicillins and cephalosporins on the cell wall framework?
What specific part of the penicillin molecule plays a key role in influencing the antibiotic activity?
What specific part of the penicillin molecule plays a key role in influencing the antibiotic activity?
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