Penicillin G Acid Sensitivity Reasons
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Questions and Answers

What is one of the three reasons for the acid sensitivity of penicillin G?

  • Strong acidic pH environment
  • Ring strain (correct)
  • Electronegative oxygen on the acyl side chain
  • Highly reactive alkene group
  • Which group in penicillin G is highly reactive and contributes to its acid sensitivity?

  • Acylation group
  • B-lactam carbonyl group (correct)
  • Tertiary amine group
  • Alkene group
  • How does penicillin V differ from penicillin G in terms of its acyl side chain?

  • Penicillin V has a positively charged acyl side chain
  • Penicillin V has an electronegative oxygen on the acyl side chain (correct)
  • Penicillin V has a larger acyl side chain
  • Penicillin V has a less stable acyl side chain
  • What is the influence of the acyl chain in Penicillins and Cephalosporins?

    <p>It determines the spectrum of antimicrobial activity.</p> Signup and view all the answers

    Which part of the antibiotics is responsible for the unique lethal antibacterial action in Penicillins and Cephalosporins?

    <p>The acyl chain</p> Signup and view all the answers

    What is the main function of the cell wall in bacteria?

    <p>To regulate osmotic pressure</p> Signup and view all the answers

    Which part of Penicillins and Cephalosporins is essential for inhibiting bacterial cell wall synthesis?

    <p>The acyl chain</p> Signup and view all the answers

    What type of bonds are present in the peptidoglycan structure of bacterial cell walls?

    <p>'Glycosidic' bonds</p> Signup and view all the answers

    Which textbook would be most useful for understanding the principles of medicinal chemistry related to antibiotics?

    <p>W.O. Foye, Principles of Medicinal Chemistry</p> Signup and view all the answers

    Which enzyme is responsible for the final cross-linking reaction in cell wall biosynthesis?

    <p>Transpeptidase enzyme</p> Signup and view all the answers

    How are penicillins and cephalosporins affecting the cell wall structure?

    <p>Inhibit the final cross-linking reaction</p> Signup and view all the answers

    What happens to the cell when the cell wall becomes leaky due to the inhibition by penicillins and cephalosporins?

    <p>The cell swells and eventually lyses</p> Signup and view all the answers

    Which molecule displaces D-alanine in one peptide chain during the final cross-linking reaction?

    <p>Glycine</p> Signup and view all the answers

    What is the influence of penicillins and cephalosporins on the cell wall framework?

    <p>Prevent meshing of the cell wall framework</p> Signup and view all the answers

    What specific part of the penicillin molecule plays a key role in influencing the antibiotic activity?

    <p>Acyl chain</p> Signup and view all the answers

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