Pathology of Necrosis and Gangrene

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Necrosis is a pathologic process that is the consequence of severe ______.

injury

Coagulative necrosis is most commonly seen in hypoxic death of all tissues except the ______.

brain

In coagulative necrosis, the injury denatures structural proteins and ______ - blocking the cellular proteolysis.

enzymes

If associated with acute inflammation, material is creamy yellow due to dead ______ cells

white Signup and view all the answers

Liquefactive necrosis is characterized by the digestion of dead cells –transformation of tissue into a ______ viscous mass.

liquid Signup and view all the answers

Histology shows ______ acidophilic fluid with complete destruction of cells

amorphous Signup and view all the answers

In liquefactive necrosis, microbes stimulate the accumulation of ______ and liberation of enzymes from these cells.

leucocytes Signup and view all the answers

Gangrenous necrosis is a type of necrosis caused by ______ and the attracted leucocytes

bacteria Signup and view all the answers

In caseous necrosis, the affected area appears soft, friable ______ cheesy material

white Signup and view all the answers

The affected area in liquefactive necrosis is soft, ______, viscous mass.

liquid Signup and view all the answers

Fat necrosis is seen in ______ haemorrhagic pancreatitis

acute Signup and view all the answers

The fatty acids combine with ______ to produce visible chalky white areas in fat necrosis

calcium Signup and view all the answers

The _________ necrosis is a special form of necrosis usually seen in immune reaction involving blood vessels.

fibrinoid Signup and view all the answers

The amorphous granular deposits are surrounded by _________ reaction in histology.

inflammatory Signup and view all the answers

The _________ gangrene is characterized by limited putrefaction and absence of bacteria.

dry Signup and view all the answers

The traumatic fat necrosis occurs due to _________ to superficial adipose tissue.

trauma Signup and view all the answers

The fibrinoid necrosis appears as _________ and amorphous in H&E stains.

bright pink Signup and view all the answers

The wet gangrene is more common in _________ occlusion followed by secondary bacterial infection.

venous Signup and view all the answers

What is the primary outcome of coagulative necrosis?

Preservation of basic structural outline Signup and view all the answers

What is the characteristic of liquefactive necrosis?

Formation of a liquid viscous mass Signup and view all the answers

What is the difference between dry and wet gangrene?

Dry gangrene is characterized by limited putrefaction and absence of bacteria Signup and view all the answers

What is the primary cause of fat necrosis?

Trauma to superficial adipose tissue Signup and view all the answers

What is the characteristic of caseous necrosis?

Soft, friable, and cheesy material Signup and view all the answers

What is the definition of necrosis?

A pathologic process that is the consequence of severe injury Signup and view all the answers

What is the primary cause of caseous necrosis?

Hypersensitivity reaction to bacterial lipopolysaccharide Signup and view all the answers

What is the characteristic gross appearance of fat necrosis?

Variegated appearance with gray white necrotic areas Signup and view all the answers

What is the result of the combination of fatty acids with calcium in fat necrosis?

Visible chalky white areas Signup and view all the answers

What is the characteristic histological feature of gangrenous necrosis?

Amorphous acidophilic fluid with complete destruction of cells Signup and view all the answers

What is the primary cause of wet gangrene?

Venous occlusion followed by secondary bacterial infection Signup and view all the answers

What is the primary site of dry gangrene?

Lower leg Signup and view all the answers

What is the result of the release of activated pancreatic lipases in fat necrosis?

Liquefaction of fat cells Signup and view all the answers

What is the characteristic appearance of fibrinoid necrosis in H&E stains?

Bright pink and amorphous Signup and view all the answers

What is the primary difference between dry and wet gangrene in terms of putrefaction?

Dry gangrene has limited putrefaction, while wet gangrene has marked putrefaction Signup and view all the answers

What is the characteristic distribution of dry gangrene?

Limbs only Signup and view all the answers

What is the histological appearance of traumatic fat necrosis?

Focal area of necrotic fat cells surrounded by neutrophils and lipid-filled macrophages Signup and view all the answers

What is the characteristic gross appearance of dry gangrene?

Dry, shrunken, and black Signup and view all the answers