Pathology of Necrosis and Gangrene
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Questions and Answers

Necrosis is a pathologic process that is the consequence of severe ______.

injury

Coagulative necrosis is most commonly seen in hypoxic death of all tissues except the ______.

brain

In coagulative necrosis, the injury denatures structural proteins and ______ - blocking the cellular proteolysis.

enzymes

If associated with acute inflammation, material is creamy yellow due to dead ______ cells

<p>white</p> Signup and view all the answers

Liquefactive necrosis is characterized by the digestion of dead cells –transformation of tissue into a ______ viscous mass.

<p>liquid</p> Signup and view all the answers

Histology shows ______ acidophilic fluid with complete destruction of cells

<p>amorphous</p> Signup and view all the answers

In liquefactive necrosis, microbes stimulate the accumulation of ______ and liberation of enzymes from these cells.

<p>leucocytes</p> Signup and view all the answers

Gangrenous necrosis is a type of necrosis caused by ______ and the attracted leucocytes

<p>bacteria</p> Signup and view all the answers

In caseous necrosis, the affected area appears soft, friable ______ cheesy material

<p>white</p> Signup and view all the answers

The affected area in liquefactive necrosis is soft, ______, viscous mass.

<p>liquid</p> Signup and view all the answers

Fat necrosis is seen in ______ haemorrhagic pancreatitis

<p>acute</p> Signup and view all the answers

The fatty acids combine with ______ to produce visible chalky white areas in fat necrosis

<p>calcium</p> Signup and view all the answers

The _________ necrosis is a special form of necrosis usually seen in immune reaction involving blood vessels.

<p>fibrinoid</p> Signup and view all the answers

The amorphous granular deposits are surrounded by _________ reaction in histology.

<p>inflammatory</p> Signup and view all the answers

The _________ gangrene is characterized by limited putrefaction and absence of bacteria.

<p>dry</p> Signup and view all the answers

The traumatic fat necrosis occurs due to _________ to superficial adipose tissue.

<p>trauma</p> Signup and view all the answers

The fibrinoid necrosis appears as _________ and amorphous in H&E stains.

<p>bright pink</p> Signup and view all the answers

The wet gangrene is more common in _________ occlusion followed by secondary bacterial infection.

<p>venous</p> Signup and view all the answers

What is the primary outcome of coagulative necrosis?

<p>Preservation of basic structural outline</p> Signup and view all the answers

What is the characteristic of liquefactive necrosis?

<p>Formation of a liquid viscous mass</p> Signup and view all the answers

What is the difference between dry and wet gangrene?

<p>Dry gangrene is characterized by limited putrefaction and absence of bacteria</p> Signup and view all the answers

What is the primary cause of fat necrosis?

<p>Trauma to superficial adipose tissue</p> Signup and view all the answers

What is the characteristic of caseous necrosis?

<p>Soft, friable, and cheesy material</p> Signup and view all the answers

What is the definition of necrosis?

<p>A pathologic process that is the consequence of severe injury</p> Signup and view all the answers

What is the primary cause of caseous necrosis?

<p>Hypersensitivity reaction to bacterial lipopolysaccharide</p> Signup and view all the answers

What is the characteristic gross appearance of fat necrosis?

<p>Variegated appearance with gray white necrotic areas</p> Signup and view all the answers

What is the result of the combination of fatty acids with calcium in fat necrosis?

<p>Visible chalky white areas</p> Signup and view all the answers

What is the characteristic histological feature of gangrenous necrosis?

<p>Amorphous acidophilic fluid with complete destruction of cells</p> Signup and view all the answers

What is the primary cause of wet gangrene?

<p>Venous occlusion followed by secondary bacterial infection</p> Signup and view all the answers

What is the primary site of dry gangrene?

<p>Lower leg</p> Signup and view all the answers

What is the result of the release of activated pancreatic lipases in fat necrosis?

<p>Liquefaction of fat cells</p> Signup and view all the answers

What is the characteristic appearance of fibrinoid necrosis in H&E stains?

<p>Bright pink and amorphous</p> Signup and view all the answers

What is the primary difference between dry and wet gangrene in terms of putrefaction?

<p>Dry gangrene has limited putrefaction, while wet gangrene has marked putrefaction</p> Signup and view all the answers

What is the characteristic distribution of dry gangrene?

<p>Limbs only</p> Signup and view all the answers

What is the histological appearance of traumatic fat necrosis?

<p>Focal area of necrotic fat cells surrounded by neutrophils and lipid-filled macrophages</p> Signup and view all the answers

What is the characteristic gross appearance of dry gangrene?

<p>Dry, shrunken, and black</p> Signup and view all the answers

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