33 Questions
What is the main function of Lifitegrast (Xiidra)?
Inhibiting the interaction between LFA-1 and ICAM-1
Which cell surface protein is found on leukocytes?
LFA-1
What is the role of ICAM-1 in DED corneal and conjunctival tissues?
Facilitating leukocyte adhesion
Which molecule can contribute to the formation of immunological synapse resulting in T-cell activation?
LFA-1
What is the function of APC in the immune system?
Presenting antigens to T cells
What is MHC in the context of immune system?
A complex involved in antigen presentation
What does TCR stand for in the context of immune system?
T Cell Receptor
What is the function of LFA-1 in immune response?
Mediating leukocyte adhesion
What role does Lifitegrast play in the interaction between LFA-1 and ICAM-1?
It weakens or inhibits the interaction
What is the potential effect of chronic use of topical corticosteroids on the eyes?
Increased intraocular pressure (IOP) and risk of cataract formation
What is the author's conclusion about the evidence of using topical steroids for dry eye?
Moderate to very low certainty evidence of small to moderate symptom relief
Based on the implications for practice, how does the use of topical corticosteroids compare to artificial tears for dry eye treatment?
Likely provides small to moderate improvement in symptoms
What does the evidence support regarding the effects of topical corticosteroids on corneal staining scores?
Reduced corneal staining scores compared to lubricants
What is uncertain regarding the effects of topical corticosteroids on tear quality or production?
No effect on tear film quality or quantity
What is one of the potential adverse effects related to the use of topical corticosteroids according to the text?
Increased risk of cataract formation or progression
What is uncertain about the potential effects of short-term use of topical steroids on intraocular pressure (IOP)?
It is uncertain whether they elevate IOP
What does the evidence suggest about the effects of using topical corticosteroids compared to cyclosporine A for dry eye treatment?
Topical corticosteroids have less certain effects on symptoms compared to cyclosporine A
What is the expected timeline for significant improvement when using Cyclosporine 0.05% (Restasis) for dry eyes?
6 months
Why is it recommended to put the patient on a steroid initially when using Cyclosporine 0.05% (Restasis)?
To reduce symptoms immediately
In which conditions is the use of Cyclosporine 0.05% (Restasis) contraindicated?
Ocular infections
What is the desired response on Schirmer 2 to ensure the effectiveness of Cyclosporine 0.05% (Restasis)?
< 3 mm wet with nasal stimulation
What is a consideration to keep in mind when prescribing Cyclosporine 0.05% (Restasis) for dry eyes?
Diffuse loss of goblet cells will have no effect on its efficacy
What is the recommended dosage for Cyclosporine 0.05% (Restasis)?
Twice daily
What is the expected maintenance schedule after significant improvement has been achieved with Cyclosporine 0.05% (Restasis)?
Once or twice a week
What is a characteristic of the dosage form of Cyclosporine 0.05% (Restasis)?
Viscous gel
What is Vevye (cyclosporine 0.1% ophthalmic solution) known for in comparison to other cyclosporine formulations?
It has improved tolerability and decreased visual disturbance compared to other formulations with surfactants and oils.
Which drug is a Lymphocyte function-associated antigen-1 (LFA-1) antagonist?
Lifitegrast (Xiidra 5%)
What is the specific advantage of using Vevye (cyclosporine 0.1% ophthalmic solution) as miebo?
It provides immediate effects in combination with enhanced local bioavailability.
What does most studies say about the effect of the mechanism on T-cells?
The mechanism has no impact on the time it takes for T-cells to respond.
What is the classification of CyclASol 0.1%?
Water-free semifluorinated alkane (SFA) solution
Which drug was approved for the treatment of signs/symptoms of dry eye disease in July 2016?
Lifitegrast (Xiidra 5%)
What is the specific dosage recommendation for Lifitegrast (Xiidra 5%)?
Twice daily
How does Lifitegrast (Xiidra 5%) interact with the surface of the eye?
It nicely coats the eye without causing much blurring due to its interaction with the surface of the eye.
Test your knowledge on ocular surface disease treatment options and pharmacology with this quiz. Explore the efficiency of Vevye (cyclosporine 0.1% ophthalmic solution) and its comparison to other cyclosporines in terms of drug delivery and efficacy.
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