Ocular Surface Disease Treatment Options: Pharmacology II Quiz
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Questions and Answers

What is the main function of Lifitegrast (Xiidra)?

  • Inhibiting the interaction between LFA-1 and ICAM-1 (correct)
  • Promoting the formation of immunological synapse
  • Facilitating the overexpression of ICAM-1
  • Stimulating T-cell activation

    • Which cell surface protein is found on leukocytes?

  • MHC
  • LFA-1 (correct)
  • TCR
  • ICAM-1

    • What is the role of ICAM-1 in DED corneal and conjunctival tissues?

  • Facilitating leukocyte adhesion (correct)
  • Preventing immunological synapse formation
  • Suppressing inflammation
  • Activating T-cell receptors

    • Which molecule can contribute to the formation of immunological synapse resulting in T-cell activation?

    <p>LFA-1</p> Signup and view all the answers

    What is the function of APC in the immune system?

    <p>Presenting antigens to T cells</p> Signup and view all the answers

    What is MHC in the context of immune system?

    <p>A complex involved in antigen presentation</p> Signup and view all the answers

    What does TCR stand for in the context of immune system?

    <p>T Cell Receptor</p> Signup and view all the answers

    What is the function of LFA-1 in immune response?

    <p>Mediating leukocyte adhesion</p> Signup and view all the answers

    What role does Lifitegrast play in the interaction between LFA-1 and ICAM-1?

    <p>It weakens or inhibits the interaction</p> Signup and view all the answers

    What is the potential effect of chronic use of topical corticosteroids on the eyes?

    <p>Increased intraocular pressure (IOP) and risk of cataract formation</p> Signup and view all the answers

    What is the author's conclusion about the evidence of using topical steroids for dry eye?

    <p>Moderate to very low certainty evidence of small to moderate symptom relief</p> Signup and view all the answers

    Based on the implications for practice, how does the use of topical corticosteroids compare to artificial tears for dry eye treatment?

    <p>Likely provides small to moderate improvement in symptoms</p> Signup and view all the answers

    What does the evidence support regarding the effects of topical corticosteroids on corneal staining scores?

    <p>Reduced corneal staining scores compared to lubricants</p> Signup and view all the answers

    What is uncertain regarding the effects of topical corticosteroids on tear quality or production?

    <p>No effect on tear film quality or quantity</p> Signup and view all the answers

    What is one of the potential adverse effects related to the use of topical corticosteroids according to the text?

    <p>Increased risk of cataract formation or progression</p> Signup and view all the answers

    What is uncertain about the potential effects of short-term use of topical steroids on intraocular pressure (IOP)?

    <p>It is uncertain whether they elevate IOP</p> Signup and view all the answers

    What does the evidence suggest about the effects of using topical corticosteroids compared to cyclosporine A for dry eye treatment?

    <p>Topical corticosteroids have less certain effects on symptoms compared to cyclosporine A</p> Signup and view all the answers

    What is the expected timeline for significant improvement when using Cyclosporine 0.05% (Restasis) for dry eyes?

    <p>6 months</p> Signup and view all the answers

    Why is it recommended to put the patient on a steroid initially when using Cyclosporine 0.05% (Restasis)?

    <p>To reduce symptoms immediately</p> Signup and view all the answers

    In which conditions is the use of Cyclosporine 0.05% (Restasis) contraindicated?

    <p>Ocular infections</p> Signup and view all the answers

    What is the desired response on Schirmer 2 to ensure the effectiveness of Cyclosporine 0.05% (Restasis)?

    <p>&lt; 3 mm wet with nasal stimulation</p> Signup and view all the answers

    What is a consideration to keep in mind when prescribing Cyclosporine 0.05% (Restasis) for dry eyes?

    <p>Diffuse loss of goblet cells will have no effect on its efficacy</p> Signup and view all the answers

    What is the recommended dosage for Cyclosporine 0.05% (Restasis)?

    <p>Twice daily</p> Signup and view all the answers

    What is the expected maintenance schedule after significant improvement has been achieved with Cyclosporine 0.05% (Restasis)?

    <p>Once or twice a week</p> Signup and view all the answers

    What is a characteristic of the dosage form of Cyclosporine 0.05% (Restasis)?

    <p>Viscous gel</p> Signup and view all the answers

    What is Vevye (cyclosporine 0.1% ophthalmic solution) known for in comparison to other cyclosporine formulations?

    <p>It has improved tolerability and decreased visual disturbance compared to other formulations with surfactants and oils.</p> Signup and view all the answers

    Which drug is a Lymphocyte function-associated antigen-1 (LFA-1) antagonist?

    <p>Lifitegrast (Xiidra 5%)</p> Signup and view all the answers

    What is the specific advantage of using Vevye (cyclosporine 0.1% ophthalmic solution) as miebo?

    <p>It provides immediate effects in combination with enhanced local bioavailability.</p> Signup and view all the answers

    What does most studies say about the effect of the mechanism on T-cells?

    <p>The mechanism has no impact on the time it takes for T-cells to respond.</p> Signup and view all the answers

    What is the classification of CyclASol 0.1%?

    <p>Water-free semifluorinated alkane (SFA) solution</p> Signup and view all the answers

    Which drug was approved for the treatment of signs/symptoms of dry eye disease in July 2016?

    <p>Lifitegrast (Xiidra 5%)</p> Signup and view all the answers

    What is the specific dosage recommendation for Lifitegrast (Xiidra 5%)?

    <p>Twice daily</p> Signup and view all the answers

    How does Lifitegrast (Xiidra 5%) interact with the surface of the eye?

    <p>It nicely coats the eye without causing much blurring due to its interaction with the surface of the eye.</p> Signup and view all the answers

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