18 Questions
What is the primary function of COX-1 enzyme?
To regulate physiological functions in tissues
What is the role of thromboxane in the body?
To increase platelet aggregation and vasoconstriction
What is the function of prostacyclin released from endothelium?
To decrease platelet aggregation and vasodilation
What is the role of COX-2 enzyme in the body?
To induce pain, fever, and inflammation
What is the function of COX-3 enzyme in the body?
To regulate functions in the brain
What is the role of leukotrienes in the body?
To stimulate bronchospasm and inflammation
Which of the following processes is responsible for the release of arachidonic acid?
Phospholipase A2 activation
What is the primary site of COX-3 enzyme expression?
Brain
Which of the following prostaglandins is responsible for maintaining the patency of the ductus arteriosus in the fetus?
PGE2
What is the primary mechanism by which NSAIDs prevent peptic ulcers?
Inhibition of COX-1 enzyme
Which of the following is a consequence of COX-2 induction in response to inflammation or injury?
Increased synthesis of prostaglandins
Which of the following is a function of prostaglandins in the uterus?
Contraction of uterine smooth muscle
In which tissue is COX-1 primarily responsible for forming protective prostaglandins?
Gastrointestinal Tract
What is the primary function of phospholipase A2 in prostaglandin synthesis?
To release arachidonic acid from phospholipids
What is the primary mechanism by which prostaglandins prevent peptic ulcers?
By maintaining the mucoprotective layer of the stomach
Which of the following is NOT a consequence of COX-1 inhibition?
Increased platelet aggregation
What is the primary function of thromboxane released from platelets?
To increase platelet aggregation
What percentage of arachidonic acid is converted into prostaglandins by COX enzymes?
90%
Test your knowledge of Non-steroidal Anti-inflammatory drugs (NSAIDs) and their effect on Cyclo-Oxygenase (COX) Enzymes, including COX-1, COX-2, and COX-3. Learn about their roles in prostaglandins synthesis and physiological functions.
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