Neuropathic Pain and Nociceptive Pain Types
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Questions and Answers

What is the primary cause of radicular pain?

  • Injury or inflammation in internal organs
  • Damage to the nervous system
  • Stimulation of pain receptors in tissues
  • Irritation of nerve roots (correct)

What is visceral pain often described as?

  • Aching and may have a vague location (correct)
  • Aching and having a precise location
  • Sharp and stabbing
  • Vague and localized

Which of the following is NOT a cause of neuropathic pain?

  • Inflammation in muscles
  • Spinal cord compression
  • Diabetes
  • Stimulation of pain receptors in tissues (correct)

What is the term for an increase in the perception of pain generated by a stimulus that causes pain?

<p>Hyperalgesia (D)</p> Signup and view all the answers

What is the primary focus of neuropathic pain management?

<p>Treating symptoms and sometimes etiological causes (B)</p> Signup and view all the answers

Which of the following is a symptom of neuropathic pain?

<p>Paresthesia (C)</p> Signup and view all the answers

Which medication is most effective in reducing neuropathic pain?

<p>Duloxetine (B)</p> Signup and view all the answers

What is the mechanism of action of lidocaine patches in reducing neuropathic pain?

<p>Blocking voltage-gated sodium channels (A)</p> Signup and view all the answers

What is the action of capsaicin on the TRPV1 receptor?

<p>Agonism (B)</p> Signup and view all the answers

What is the additional effect of tramadol that contributes to its analgesic properties in neuropathic pain?

<p>Serotonin inhibition and norepinephrine reuptake (D)</p> Signup and view all the answers

What is the common side effect of duloxetine and venlafaxine that necessitates caution in patients with cardiac disease?

<p>Increased blood pressure and cardiac conduction abnormalities (B)</p> Signup and view all the answers

What is the effect of oxycodone and morphine on the sensation of pain?

<p>Increase in tolerance to pain (D)</p> Signup and view all the answers

What is the mechanism of action of Tricyclic Antidepressants in relation to serotonin and noradrenaline?

<p>They inhibit the reuptake of serotonin and noradrenaline (A)</p> Signup and view all the answers

Which of the following conditions is Tricyclic Antidepressants contraindicated in?

<p>Some cardiac conduction disturbances (D)</p> Signup and view all the answers

What is the target of Gabapentin and Pregabalin in the treatment of pain?

<p>The α2-δ subunit of Ca²+ voltage-dependent channels (A)</p> Signup and view all the answers

What is the effect of Gabapentin and Pregabalin on Ca²+ influx to the cells?

<p>Decrease Ca²+ influx (A)</p> Signup and view all the answers

Which of the following is NOT a first-line treatment for painful neuropathy?

<p>Strong opioids (A)</p> Signup and view all the answers

What is the mechanism of action of Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) in relation to serotonin and norepinephrine?

<p>They inhibit the reuptake of serotonin and norepinephrine (C)</p> Signup and view all the answers

What is the primary mechanism of action of Lidocaine patches in reducing neuropathic pain?

<p>Blocking voltage-gated sodium channels (B)</p> Signup and view all the answers

What is the effect of Capsaicin on the sensation of temperature?

<p>It is sensitive to different ranges of temperature (B)</p> Signup and view all the answers

Why should Duloxetine and Venlafaxine be used cautiously in patients with cardiac disease?

<p>Because they can cause cardiac conduction abnormalities (C)</p> Signup and view all the answers

What is the additional mechanism of action of Tramadol that contributes to its analgesic properties in neuropathic pain?

<p>All of the above (D)</p> Signup and view all the answers

What is the primary effect of Oxycodone and Morphine on the sensation of pain?

<p>They decrease the discomfort of pain by increasing tolerance (D)</p> Signup and view all the answers

What is the primary mechanism of action of Capsaicin?

<p>It is a potent receptor agonist of TRPV1 (C)</p> Signup and view all the answers

What is the effect of Amitriptyline on cholinergic, adrenergic, and histaminergic receptors and ionic channels?

<p>Inhibition (B)</p> Signup and view all the answers

What type of pain occurs when pain receptors in tissues are stimulated?

<p>Somatic pain (C)</p> Signup and view all the answers

Which of the following is a cause of neuropathic pain?

<p>Nerve injury due to diabetes (B)</p> Signup and view all the answers

Which of the following medications is used to treat pain following spinal cord injury?

<p>Amitriptyline (A)</p> Signup and view all the answers

What is the binding site of Gabapentin and Pregabalin in the treatment of pain?

<p>α2-δ subunit of Ca²+ voltage-dependent channels (B)</p> Signup and view all the answers

What is the characteristic of visceral pain?

<p>It is often described as aching and has a vague location (C)</p> Signup and view all the answers

What is the focus of neuropathic pain management?

<p>Treating the symptoms of pain (B)</p> Signup and view all the answers

What is the side effect of Gabapentin and Pregabalin that is related to movement?

<p>Ataxia (C)</p> Signup and view all the answers

What is the mechanism of action of Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) in relation to serotonin and norepinephrine?

<p>Inhibition of serotonin and norepinephrine reuptake (A)</p> Signup and view all the answers

What is the term for pain due to a stimulus that does not normally provoke pain?

<p>Allodynia (A)</p> Signup and view all the answers

In which patients are Tricyclic Antidepressants contraindicated?

<p>All of the above (D)</p> Signup and view all the answers

Which of the following is a sign of neuropathic pain?

<p>Pins and needles (C)</p> Signup and view all the answers

What is the result of nerve injury or diseases such as diabetes, shingles, or cancer?

<p>Neuropathic pain (A)</p> Signup and view all the answers

What is the characteristic of pain that occurs when pain receptors in internal organs are stimulated?

<p>It is often described as aching and may have a vague location (C)</p> Signup and view all the answers

What is the focus of neuropathic pain management?

<p>Treating symptoms and occasionally the underlying causes (B)</p> Signup and view all the answers

What is the term for pins and needles sensation?

<p>Paresthesia (C)</p> Signup and view all the answers

What is the result of pain receptors in tissues being stimulated?

<p>Somatic pain (D)</p> Signup and view all the answers

What is the term for an increase in the perception of pain generated by a stimulus that causes pain?

<p>Hyperalgesia (A)</p> Signup and view all the answers

What is the mechanism of action of Tricyclic Antidepressants (TCAs) in terms of serotonin and noradrenaline?

<p>They inhibit the reuptake of serotonin and noradrenaline. (C)</p> Signup and view all the answers

What is the common side effect of Gabapentin and Pregabalin that is related to the central nervous system?

<p>Dizziness (A)</p> Signup and view all the answers

Which of the following medications is used to treat neuropathic pain by binding to the alpha-2 delta subunit of calcium channels?

<p>Gabapentin (C)</p> Signup and view all the answers

What is the contraindication for Tricyclic Antidepressants (TCAs) in terms of cardiac conditions?

<p>Some cardiac conduction disturbances (B)</p> Signup and view all the answers

What is the mechanism of action of Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) in terms of serotonin and noradrenaline?

<p>They inhibit the reuptake of serotonin and noradrenaline. (B)</p> Signup and view all the answers

What is the indication for the use of strong opioids, such as oxycodone and tramadol, in the treatment of neuropathic pain?

<p>Third-line treatment (D)</p> Signup and view all the answers

What is the primary effect of Oxycodone and Morphine on the sensation of pain?

<p>Decrease discomfort by increasing the tolerance to pain (A)</p> Signup and view all the answers

What is the mechanism of action of Capsaicin?

<p>Acting as a potent receptor agonist (TRPV1) (C)</p> Signup and view all the answers

Why should Duloxetine and Venlafaxine be used cautiously in patients with cardiac disease?

<p>Because they can increase blood pressure and cardiac conduction abnormalities (B)</p> Signup and view all the answers

What is the mechanism of action of Tramadol in reducing neuropathic pain?

<p>Inhibiting serotonin and norepinephrine reuptake, and acting as a µ-opioid agonist (D)</p> Signup and view all the answers

What is the effect of Lidocaine patches on neuropathic pain?

<p>Reduce spontaneous ectopic nerve discharge (A)</p> Signup and view all the answers

What is the characteristic of Capsaicin molecule?

<p>Produce the same sensation that excessive heat or abrasive damage would cause (C)</p> Signup and view all the answers

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