Neuropathic Pain and Nociceptive Pain Types
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Questions and Answers

What is the primary cause of radicular pain?

  • Injury or inflammation in internal organs
  • Damage to the nervous system
  • Stimulation of pain receptors in tissues
  • Irritation of nerve roots (correct)

    • What is visceral pain often described as?

  • Aching and may have a vague location (correct)
  • Aching and having a precise location
  • Sharp and stabbing
  • Vague and localized

    • Which of the following is NOT a cause of neuropathic pain?

  • Inflammation in muscles
  • Spinal cord compression
  • Diabetes
  • Stimulation of pain receptors in tissues (correct)

    • What is the term for an increase in the perception of pain generated by a stimulus that causes pain?

    <p>Hyperalgesia</p> Signup and view all the answers

    What is the primary focus of neuropathic pain management?

    <p>Treating symptoms and sometimes etiological causes</p> Signup and view all the answers

    Which of the following is a symptom of neuropathic pain?

    <p>Paresthesia</p> Signup and view all the answers

    Which medication is most effective in reducing neuropathic pain?

    <p>Duloxetine</p> Signup and view all the answers

    What is the mechanism of action of lidocaine patches in reducing neuropathic pain?

    <p>Blocking voltage-gated sodium channels</p> Signup and view all the answers

    What is the action of capsaicin on the TRPV1 receptor?

    <p>Agonism</p> Signup and view all the answers

    What is the additional effect of tramadol that contributes to its analgesic properties in neuropathic pain?

    <p>Serotonin inhibition and norepinephrine reuptake</p> Signup and view all the answers

    What is the common side effect of duloxetine and venlafaxine that necessitates caution in patients with cardiac disease?

    <p>Increased blood pressure and cardiac conduction abnormalities</p> Signup and view all the answers

    What is the effect of oxycodone and morphine on the sensation of pain?

    <p>Increase in tolerance to pain</p> Signup and view all the answers

    What is the mechanism of action of Tricyclic Antidepressants in relation to serotonin and noradrenaline?

    <p>They inhibit the reuptake of serotonin and noradrenaline</p> Signup and view all the answers

    Which of the following conditions is Tricyclic Antidepressants contraindicated in?

    <p>Some cardiac conduction disturbances</p> Signup and view all the answers

    What is the target of Gabapentin and Pregabalin in the treatment of pain?

    <p>The α2-δ subunit of Ca²+ voltage-dependent channels</p> Signup and view all the answers

    What is the effect of Gabapentin and Pregabalin on Ca²+ influx to the cells?

    <p>Decrease Ca²+ influx</p> Signup and view all the answers

    Which of the following is NOT a first-line treatment for painful neuropathy?

    <p>Strong opioids</p> Signup and view all the answers

    What is the mechanism of action of Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) in relation to serotonin and norepinephrine?

    <p>They inhibit the reuptake of serotonin and norepinephrine</p> Signup and view all the answers

    What is the primary mechanism of action of Lidocaine patches in reducing neuropathic pain?

    <p>Blocking voltage-gated sodium channels</p> Signup and view all the answers

    What is the effect of Capsaicin on the sensation of temperature?

    <p>It is sensitive to different ranges of temperature</p> Signup and view all the answers

    Why should Duloxetine and Venlafaxine be used cautiously in patients with cardiac disease?

    <p>Because they can cause cardiac conduction abnormalities</p> Signup and view all the answers

    What is the additional mechanism of action of Tramadol that contributes to its analgesic properties in neuropathic pain?

    <p>All of the above</p> Signup and view all the answers

    What is the primary effect of Oxycodone and Morphine on the sensation of pain?

    <p>They decrease the discomfort of pain by increasing tolerance</p> Signup and view all the answers

    What is the primary mechanism of action of Capsaicin?

    <p>It is a potent receptor agonist of TRPV1</p> Signup and view all the answers

    What is the effect of Amitriptyline on cholinergic, adrenergic, and histaminergic receptors and ionic channels?

    <p>Inhibition</p> Signup and view all the answers

    What type of pain occurs when pain receptors in tissues are stimulated?

    <p>Somatic pain</p> Signup and view all the answers

    Which of the following is a cause of neuropathic pain?

    <p>Nerve injury due to diabetes</p> Signup and view all the answers

    Which of the following medications is used to treat pain following spinal cord injury?

    <p>Amitriptyline</p> Signup and view all the answers

    What is the binding site of Gabapentin and Pregabalin in the treatment of pain?

    <p>α2-δ subunit of Ca²+ voltage-dependent channels</p> Signup and view all the answers

    What is the characteristic of visceral pain?

    <p>It is often described as aching and has a vague location</p> Signup and view all the answers

    What is the focus of neuropathic pain management?

    <p>Treating the symptoms of pain</p> Signup and view all the answers

    What is the side effect of Gabapentin and Pregabalin that is related to movement?

    <p>Ataxia</p> Signup and view all the answers

    What is the mechanism of action of Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) in relation to serotonin and norepinephrine?

    <p>Inhibition of serotonin and norepinephrine reuptake</p> Signup and view all the answers

    What is the term for pain due to a stimulus that does not normally provoke pain?

    <p>Allodynia</p> Signup and view all the answers

    In which patients are Tricyclic Antidepressants contraindicated?

    <p>All of the above</p> Signup and view all the answers

    Which of the following is a sign of neuropathic pain?

    <p>Pins and needles</p> Signup and view all the answers

    What is the result of nerve injury or diseases such as diabetes, shingles, or cancer?

    <p>Neuropathic pain</p> Signup and view all the answers

    What is the characteristic of pain that occurs when pain receptors in internal organs are stimulated?

    <p>It is often described as aching and may have a vague location</p> Signup and view all the answers

    What is the focus of neuropathic pain management?

    <p>Treating symptoms and occasionally the underlying causes</p> Signup and view all the answers

    What is the term for pins and needles sensation?

    <p>Paresthesia</p> Signup and view all the answers

    What is the result of pain receptors in tissues being stimulated?

    <p>Somatic pain</p> Signup and view all the answers

    What is the term for an increase in the perception of pain generated by a stimulus that causes pain?

    <p>Hyperalgesia</p> Signup and view all the answers

    What is the mechanism of action of Tricyclic Antidepressants (TCAs) in terms of serotonin and noradrenaline?

    <p>They inhibit the reuptake of serotonin and noradrenaline.</p> Signup and view all the answers

    What is the common side effect of Gabapentin and Pregabalin that is related to the central nervous system?

    <p>Dizziness</p> Signup and view all the answers

    Which of the following medications is used to treat neuropathic pain by binding to the alpha-2 delta subunit of calcium channels?

    <p>Gabapentin</p> Signup and view all the answers

    What is the contraindication for Tricyclic Antidepressants (TCAs) in terms of cardiac conditions?

    <p>Some cardiac conduction disturbances</p> Signup and view all the answers

    What is the mechanism of action of Serotonin Noradrenaline Reuptake Inhibitors (SNRIs) in terms of serotonin and noradrenaline?

    <p>They inhibit the reuptake of serotonin and noradrenaline.</p> Signup and view all the answers

    What is the indication for the use of strong opioids, such as oxycodone and tramadol, in the treatment of neuropathic pain?

    <p>Third-line treatment</p> Signup and view all the answers

    What is the primary effect of Oxycodone and Morphine on the sensation of pain?

    <p>Decrease discomfort by increasing the tolerance to pain</p> Signup and view all the answers

    What is the mechanism of action of Capsaicin?

    <p>Acting as a potent receptor agonist (TRPV1)</p> Signup and view all the answers

    Why should Duloxetine and Venlafaxine be used cautiously in patients with cardiac disease?

    <p>Because they can increase blood pressure and cardiac conduction abnormalities</p> Signup and view all the answers

    What is the mechanism of action of Tramadol in reducing neuropathic pain?

    <p>Inhibiting serotonin and norepinephrine reuptake, and acting as a µ-opioid agonist</p> Signup and view all the answers

    What is the effect of Lidocaine patches on neuropathic pain?

    <p>Reduce spontaneous ectopic nerve discharge</p> Signup and view all the answers

    What is the characteristic of Capsaicin molecule?

    <p>Produce the same sensation that excessive heat or abrasive damage would cause</p> Signup and view all the answers

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