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What is the primary mechanism of action of tricyclic antidepressants in treating neuropathic pain?
What is the primary mechanism of action of tricyclic antidepressants in treating neuropathic pain?
- Inhibition of serotonin release
- Activation of dopamine receptors
- Stimulation of GABA receptors
- Inhibition of norepinephrine reuptake (correct)
Which of the following neurotransmitters is NOT affected by tricyclic antidepressants?
Which of the following neurotransmitters is NOT affected by tricyclic antidepressants?
- Dopamine (correct)
- Serotonin
- Acetylcholine
- GABA
What is the primary indication for the use of tricyclic antidepressants mentioned in the text?
What is the primary indication for the use of tricyclic antidepressants mentioned in the text?
- Treatment of psychosis
- Treatment of anxiety disorders
- Treatment of depression
- Treatment of neuropathic pain (correct)
Which of the following is an example of a tricyclic antidepressant mentioned in the text?
Which of the following is an example of a tricyclic antidepressant mentioned in the text?
What is the effect of tricyclic antidepressants on the levels of serotonin and norepinephrine in the synaptic cleft?
What is the effect of tricyclic antidepressants on the levels of serotonin and norepinephrine in the synaptic cleft?
What is the primary function of norepinephrine and serotonin in the context of pain treatment?
What is the primary function of norepinephrine and serotonin in the context of pain treatment?
What is the effect of tricyclic antidepressants on the reuptake of neurotransmitters?
What is the effect of tricyclic antidepressants on the reuptake of neurotransmitters?
What is the common indication for the use of amitriptyline, doxepin, and imipramine?
What is the common indication for the use of amitriptyline, doxepin, and imipramine?
What is the mechanism by which tricyclic antidepressants produce an analgesic effect?
What is the mechanism by which tricyclic antidepressants produce an analgesic effect?
What is the role of serotonin and norepinephrine in the treatment of pain?
What is the role of serotonin and norepinephrine in the treatment of pain?
What is the primary action of tricyclic antidepressants on neurotransmitters in treating neuropathic pain?
What is the primary action of tricyclic antidepressants on neurotransmitters in treating neuropathic pain?
What is the effect of tricyclic antidepressants on the synaptic cleft concentration of neurotransmitters?
What is the effect of tricyclic antidepressants on the synaptic cleft concentration of neurotransmitters?
What is the common function of amitriptyline, doxepin, and imipramine in the context of pain treatment?
What is the common function of amitriptyline, doxepin, and imipramine in the context of pain treatment?
What is the primary therapeutic application of tricyclic antidepressants mentioned in the text?
What is the primary therapeutic application of tricyclic antidepressants mentioned in the text?
What is the common mechanism of action of amitriptyline, doxepin, and imipramine in the treatment of neuropathic pain?
What is the common mechanism of action of amitriptyline, doxepin, and imipramine in the treatment of neuropathic pain?
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Study Notes
Antidepressants for Neuropathic Pain
- Noradrenergic and serotonergic antidepressants are used to treat neuropathic pain.
- Tricyclics, such as amitriptyline, doxepin, and imipramine, are examples of these antidepressants.
- The mechanism of action of these antidepressants involves inhibiting the reuptake of norepinephrine and serotonin.
Antidepressants for Neuropathic Pain
- Noradrenergic and serotonergic antidepressants are used to treat neuropathic pain.
- Tricyclics, such as amitriptyline, doxepin, and imipramine, are examples of these antidepressants.
- The mechanism of action of these antidepressants involves inhibiting the reuptake of norepinephrine and serotonin.
Antidepressants for Neuropathic Pain
- Noradrenergic and serotonergic antidepressants are used to treat neuropathic pain.
- Tricyclics, such as amitriptyline, doxepin, and imipramine, are examples of these antidepressants.
- The mechanism of action of these antidepressants involves inhibiting the reuptake of norepinephrine and serotonin.
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