7 Questions
What is the primary mode of inheritance for mitochondria?
Inherited maternally via egg
At what stage does mitochondrial number increase as oocytes develop?
Primordial germ cell division
What is the range of mitochondrial copies in oogonia?
10 - 100 copies
What can occur if a person is heteroplasmic for mitochondrial disease-causing variants?
Variable distribution of disease-causing variants in resultant mature eggs
What is the approximate number of mitochondria in a mature human egg?
100,000 – 600,000
What is the primary cause of ovarian insufficiency associated with low functional mitochondrial numbers?
nDNA gene variants for proteins involved in mitochondrial replication, transcription, and translation
At what stage during embryonic development are no new mitochondria synthesized?
During cleavage
Test your knowledge of mitochondrial inheritance and the role of oocytes in passing down mitochondria. Explore the process of mitochondrial replication and the potential impact of heteroplasmy on disease distribution in eggs.
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