8 Questions
What can lead to an increase in mitochondrial number in terminally differentiated cells?
Increased energy demand
Which signaling pathway activates transcription of PGC-1α, a master regulator of genes involved in energy metabolism?
Multiple signaling pathways
What type of modification can alter the activity of PGC-1α?
Phosphorylation
What process is responsible for the selective removal of damaged or low-functioning mitochondria?
Mitophagy
Which cellular event allows for the selective removal of defunct mitochondria?
Fission
What cellular pathway is involved in the loss of mitochondria through mitophagy?
Autophagosome > lysosome pathway
Which factor mostly triggers mitophagy in mitochondria?
Low functionality
What facilitates chromatin remodeling similar to steroid receptors?
PGC-1α
Test your knowledge of mitochondrial biogenesis and its relationship to energy demand in different cell types. Explore the signaling pathways and transcriptional regulation involved in this process.
Make Your Own Quizzes and Flashcards
Convert your notes into interactive study material.
Get started for free
