Lecture 4: Pathogenesis of Hepatitis A Virus

What is the characteristic color of urine in patients with Hepatitis A Virus?

Dark cola-like

What is the primary indicator of immunity against Hepatitis A Virus?

IgG antibodies

Which of the following enzymes is NOT typically elevated in Hepatitis A Virus infection?

LDH (lactate dehydrogenase)

What is the primary method of lab diagnosis for Hepatitis A Virus?

Antibody detection using ELISA Signup and view all the answers

What is the primary mode of transmission of Hepatitis A Virus?

Fecal-oral transmission Signup and view all the answers

What is the primary goal of treatment for Hepatitis A Virus infection?

To reduce the severity of symptoms Signup and view all the answers

What is the primary location of Hepatitis A Virus replication?

Liver cells Signup and view all the answers

What is the primary function of CD8+ cytotoxic T cells in Hepatitis A infection?

Lysing HAV-infected cells Signup and view all the answers

What is a characteristic of the clinical manifestations of Hepatitis A Virus?

Acute, self-limiting infection Signup and view all the answers

What is the duration of fecal shedding of HAV after the development of clinical symptoms?

1-2 weeks Signup and view all the answers

What is the primary immune response responsible for liver injury in Hepatitis A infection?

Cell-mediated immune response Signup and view all the answers

What is the approximate duration of the incubation period of Hepatitis A Virus?

15-45 days Signup and view all the answers

What is the primary consequence of inflammation or damage to the liver?

Reduced ability to process nutrients and filter the blood Signup and view all the answers

Which of the following is NOT a common cause of hepatitis?

Bacterial infection Signup and view all the answers

How is Hepatitis A Virus (HAV) primarily spread?

By eating contaminated food or drinking contaminated water Signup and view all the answers

What is the characteristic shape of the Hepatitis A Virus (HAV)?

Icosahedral symmetry Signup and view all the answers

What is the size of the linear single-stranded RNA genome of HAV?

7.5 kb Signup and view all the answers

In which regions of the world is Hepatitis A highly endemic?

Central and South America, Africa, the Middle East, Asia, and the Western Pacific Signup and view all the answers