Lecture 4: Pathogenesis of Hepatitis A Virus
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Questions and Answers

What is the characteristic color of urine in patients with Hepatitis A Virus?

  • Light gray
  • Dark cola-like (correct)
  • Dark yellow
  • Pale orange

    • What is the primary indicator of immunity against Hepatitis A Virus?

  • IgM antibodies
  • IgG antibodies (correct)
  • Presence of antigen in the serum
  • Elevation of liver enzymes like ALT

    • Which of the following enzymes is NOT typically elevated in Hepatitis A Virus infection?

  • ALP (alkaline phosphatase)
  • ALT (alanine aminotransferase)
  • GGTP (gamma glutamyl transpeptidase)
  • LDH (lactate dehydrogenase) (correct)

    • What is the primary method of lab diagnosis for Hepatitis A Virus?

    <p>Antibody detection using ELISA</p> Signup and view all the answers

    What is the primary mode of transmission of Hepatitis A Virus?

    <p>Fecal-oral transmission</p> Signup and view all the answers

    What is the primary goal of treatment for Hepatitis A Virus infection?

    <p>To reduce the severity of symptoms</p> Signup and view all the answers

    What is the primary location of Hepatitis A Virus replication?

    <p>Liver cells</p> Signup and view all the answers

    What is the primary function of CD8+ cytotoxic T cells in Hepatitis A infection?

    <p>Lysing HAV-infected cells</p> Signup and view all the answers

    What is a characteristic of the clinical manifestations of Hepatitis A Virus?

    <p>Acute, self-limiting infection</p> Signup and view all the answers

    What is the duration of fecal shedding of HAV after the development of clinical symptoms?

    <p>1-2 weeks</p> Signup and view all the answers

    What is the primary immune response responsible for liver injury in Hepatitis A infection?

    <p>Cell-mediated immune response</p> Signup and view all the answers

    What is the approximate duration of the incubation period of Hepatitis A Virus?

    <p>15-45 days</p> Signup and view all the answers

    What is the primary consequence of inflammation or damage to the liver?

    <p>Reduced ability to process nutrients and filter the blood</p> Signup and view all the answers

    Which of the following is NOT a common cause of hepatitis?

    <p>Bacterial infection</p> Signup and view all the answers

    How is Hepatitis A Virus (HAV) primarily spread?

    <p>By eating contaminated food or drinking contaminated water</p> Signup and view all the answers

    What is the characteristic shape of the Hepatitis A Virus (HAV)?

    <p>Icosahedral symmetry</p> Signup and view all the answers

    What is the size of the linear single-stranded RNA genome of HAV?

    <p>7.5 kb</p> Signup and view all the answers

    In which regions of the world is Hepatitis A highly endemic?

    <p>Central and South America, Africa, the Middle East, Asia, and the Western Pacific</p> Signup and view all the answers

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